Magnetoliposomes Incorporated in Peptide-Based Hydrogels : Towards Development of Magnetolipogels
A major problem with magnetogels is the encapsulation of hydrophobic drugs. Magnetoliposomes not only provide these domains but also improve drug stability and avert the aggregation of the magnetic nanoparticles. In this work, two magnetoliposome architectures, solid and aqueous, were combined with supramolecular peptide-based hydrogels, which are of biomedical interest owing to their biocompatibility, easy tunability, and wide array of applications. This proof-of-concept was carried out through combination of magnetoliposomes (loaded with the model drug curcumin and the lipid probe Nile Red) with the hydrogels prior to pH triggered gelation, and fluorescence spectroscopy was used to assess the dynamics of the encapsulated molecules. These systems allow for the encapsulation of a wider array of drugs. Further, the local environment of the encapsulated molecules after gelation is unaffected by the used magnetoliposome architecture. This system design is promising for future developments on drug delivery as it provides a means to independently modify the components and adapt and optimize the design according to the required conditions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Nanomaterials (Basel, Switzerland) - 10(2020), 9 vom: 29. Aug. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Veloso, Sérgio R S [VerfasserIn] |
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| Links: |
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| Themen: |
Förster resonance energy transfer |
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| Anmerkungen: |
Date Revised 29.03.2024 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/nano10091702 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM314454500 |
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| 245 | 1 | 0 | |a Magnetoliposomes Incorporated in Peptide-Based Hydrogels |b Towards Development of Magnetolipogels |
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| 500 | |a Date Revised 29.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a A major problem with magnetogels is the encapsulation of hydrophobic drugs. Magnetoliposomes not only provide these domains but also improve drug stability and avert the aggregation of the magnetic nanoparticles. In this work, two magnetoliposome architectures, solid and aqueous, were combined with supramolecular peptide-based hydrogels, which are of biomedical interest owing to their biocompatibility, easy tunability, and wide array of applications. This proof-of-concept was carried out through combination of magnetoliposomes (loaded with the model drug curcumin and the lipid probe Nile Red) with the hydrogels prior to pH triggered gelation, and fluorescence spectroscopy was used to assess the dynamics of the encapsulated molecules. These systems allow for the encapsulation of a wider array of drugs. Further, the local environment of the encapsulated molecules after gelation is unaffected by the used magnetoliposome architecture. This system design is promising for future developments on drug delivery as it provides a means to independently modify the components and adapt and optimize the design according to the required conditions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Förster resonance energy transfer | |
| 650 | 4 | |a fluorescence | |
| 650 | 4 | |a hydrogels | |
| 650 | 4 | |a magnetolipogels | |
| 650 | 4 | |a magnetoliposomes | |
| 650 | 4 | |a self-assembly | |
| 700 | 1 | |a Andrade, Raquel G D |e verfasserin |4 aut | |
| 700 | 1 | |a Ribeiro, Beatriz C |e verfasserin |4 aut | |
| 700 | 1 | |a Fernandes, André V F |e verfasserin |4 aut | |
| 700 | 1 | |a Rodrigues, A Rita O |e verfasserin |4 aut | |
| 700 | 1 | |a Martins, J A |e verfasserin |4 aut | |
| 700 | 1 | |a Ferreira, Paula M T |e verfasserin |4 aut | |
| 700 | 1 | |a Coutinho, Paulo J G |e verfasserin |4 aut | |
| 700 | 1 | |a Castanheira, Elisabete M S |e verfasserin |4 aut | |
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