Increased Burden of Rare Sequence Variants in GnRH-Associated Genes in Women With Hypothalamic Amenorrhea
Published by Oxford University Press on behalf of the Endocrine Society 2020..
CONTEXT: Functional hypothalamic amenorrhea (HA) is a common, acquired form of hypogonadotropic hypogonadism that occurs in the setting of energy deficits and/or stress. Variability in individual susceptibility to these stressors, HA heritability, and previous identification of several rare sequence variants (RSVs) in genes associated with the rare disorder, isolated hypogonadotropic hypogonadism (IHH), in individuals with HA suggest a possible genetic contribution to HA susceptibility.
OBJECTIVE: We sought to determine whether the burden of RSVs in IHH-related genes is greater in women with HA than controls.
DESIGN: We compared patients with HA to control women.
SETTING: The study was conducted at secondary referral centers.
PATIENTS AND OTHER PARTICIPANTS: Women with HA (n = 106) and control women (ClinSeq study; n = 468).
INTERVENTIONS: We performed exome sequencing in all patients and controls.
MAIN OUTCOME MEASURE(S): The frequency of RSVs in 53 IHH-associated genes was determined using rare variant burden and association tests.
RESULTS: RSVs were overrepresented in women with HA compared with controls (P = .007). Seventy-eight heterozygous RSVs in 33 genes were identified in 58 women with HA (36.8% of alleles) compared to 255 RSVs in 41 genes among 200 control women (27.2%).
CONCLUSIONS: Women with HA are enriched for RSVs in genes that cause IHH, suggesting that variation in genes associated with gonadotropin-releasing hormone neuronal ontogeny and function may be a major determinant of individual susceptibility to developing HA in the face of diet, exercise, and/or stress.
| Errataetall: |
CommentIn: J Clin Endocrinol Metab. 2021 Mar 8;106(3):e1473-e1475. - PMID 32960961 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:106 |
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| Enthalten in: |
The Journal of clinical endocrinology and metabolism - 106(2021), 3 vom: 08. März, Seite e1441-e1452 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Delaney, Angela [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 29.09.2021 Date Revised 07.02.2024 published: Print ClinicalTrials.gov: NCT01500447, NCT00494169 CommentIn: J Clin Endocrinol Metab. 2021 Mar 8;106(3):e1473-e1475. - PMID 32960961 Citation Status MEDLINE |
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| doi: |
10.1210/clinem/dgaa609 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM314432965 |
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| 100 | 1 | |a Delaney, Angela |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Increased Burden of Rare Sequence Variants in GnRH-Associated Genes in Women With Hypothalamic Amenorrhea |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 29.09.2021 | ||
| 500 | |a Date Revised 07.02.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a ClinicalTrials.gov: NCT01500447, NCT00494169 | ||
| 500 | |a CommentIn: J Clin Endocrinol Metab. 2021 Mar 8;106(3):e1473-e1475. - PMID 32960961 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Published by Oxford University Press on behalf of the Endocrine Society 2020. | ||
| 520 | |a CONTEXT: Functional hypothalamic amenorrhea (HA) is a common, acquired form of hypogonadotropic hypogonadism that occurs in the setting of energy deficits and/or stress. Variability in individual susceptibility to these stressors, HA heritability, and previous identification of several rare sequence variants (RSVs) in genes associated with the rare disorder, isolated hypogonadotropic hypogonadism (IHH), in individuals with HA suggest a possible genetic contribution to HA susceptibility | ||
| 520 | |a OBJECTIVE: We sought to determine whether the burden of RSVs in IHH-related genes is greater in women with HA than controls | ||
| 520 | |a DESIGN: We compared patients with HA to control women | ||
| 520 | |a SETTING: The study was conducted at secondary referral centers | ||
| 520 | |a PATIENTS AND OTHER PARTICIPANTS: Women with HA (n = 106) and control women (ClinSeq study; n = 468) | ||
| 520 | |a INTERVENTIONS: We performed exome sequencing in all patients and controls | ||
| 520 | |a MAIN OUTCOME MEASURE(S): The frequency of RSVs in 53 IHH-associated genes was determined using rare variant burden and association tests | ||
| 520 | |a RESULTS: RSVs were overrepresented in women with HA compared with controls (P = .007). Seventy-eight heterozygous RSVs in 33 genes were identified in 58 women with HA (36.8% of alleles) compared to 255 RSVs in 41 genes among 200 control women (27.2%) | ||
| 520 | |a CONCLUSIONS: Women with HA are enriched for RSVs in genes that cause IHH, suggesting that variation in genes associated with gonadotropin-releasing hormone neuronal ontogeny and function may be a major determinant of individual susceptibility to developing HA in the face of diet, exercise, and/or stress | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, N.I.H., Intramural | |
| 650 | 4 | |a GnRH deficiency | |
| 650 | 4 | |a exome sequencing | |
| 650 | 4 | |a female reproduction | |
| 650 | 4 | |a genetics | |
| 650 | 4 | |a hypogonadotropic hypogonadism | |
| 650 | 7 | |a Gonadotropin-Releasing Hormone |2 NLM | |
| 650 | 7 | |a 33515-09-2 |2 NLM | |
| 700 | 1 | |a Burkholder, Adam B |e verfasserin |4 aut | |
| 700 | 1 | |a Lavender, Christopher A |e verfasserin |4 aut | |
| 700 | 1 | |a Plummer, Lacey |e verfasserin |4 aut | |
| 700 | 1 | |a Mericq, Veronica |e verfasserin |4 aut | |
| 700 | 1 | |a Merino, Paulina M |e verfasserin |4 aut | |
| 700 | 1 | |a Quinton, Richard |e verfasserin |4 aut | |
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| 700 | 1 | |a Meader, Brooke N |e verfasserin |4 aut | |
| 700 | 1 | |a Albano, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Shaw, Natalie D |e verfasserin |4 aut | |
| 700 | 1 | |a Welt, Corrine K |e verfasserin |4 aut | |
| 700 | 1 | |a Martin, Kathryn A |e verfasserin |4 aut | |
| 700 | 1 | |a Seminara, Stephanie B |e verfasserin |4 aut | |
| 700 | 1 | |a Biesecker, Leslie G |e verfasserin |4 aut | |
| 700 | 1 | |a Bailey-Wilson, Joan E |e verfasserin |4 aut | |
| 700 | 1 | |a Hall, Janet E |e verfasserin |4 aut | |
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