Age and Location in Severity of COVID-19 Pathology : Do Lactoferrin and Pneumococcal Vaccination Explain Low Infant Mortality and Regional Differences?
© 2020 Wiley Periodicals LLC..
Two conundrums puzzle COVID-19 investigators: 1) morbidity and mortality is rare among infants and young children and 2) rates of morbidity and mortality exhibit large variances across nations, locales, and even within cities. It is found that the higher the rate of pneumococcal vaccination in a nation (or city) the lower the COVID-19 morbidity and mortality. Vaccination rates with Bacillus Calmette-Guerin, poliovirus, and other vaccines do not correlate with COVID-19 risks, nor do COVID-19 case or death rates correlate with number of people in the population with diabetes, obesity, or adults over 65. Infant protection may be due to maternal antibodies and antiviral proteins in milk such as lactoferrin that are known to protect against coronavirus infections. Subsequent protection might then be conferred (and correlate with) rates of Haemophilus influenzae type B (Hib) (universal in infants) and pneumococcal vaccination, the latter varying widely by geography among infants, at-risk adults, and the elderly. Also see the video abstract here https://youtu.be/GODBYRbPL00.
| Errataetall: |
CommentIn: Bioessays. 2020 Nov;42(11):e2000234. - PMID 32902869 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:42 |
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| Enthalten in: |
BioEssays : news and reviews in molecular, cellular and developmental biology - 42(2020), 11 vom: 15. Nov., Seite e2000076 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Root-Bernstein, Robert [VerfasserIn] |
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| Links: |
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| Themen: |
Bacillus Calmette-Guerin |
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| Anmerkungen: |
Date Completed 30.10.2020 Date Revised 18.12.2020 published: Print-Electronic CommentIn: Bioessays. 2020 Nov;42(11):e2000234. - PMID 32902869 Citation Status MEDLINE |
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| doi: |
10.1002/bies.202000076 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM314423885 |
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| 520 | |a Two conundrums puzzle COVID-19 investigators: 1) morbidity and mortality is rare among infants and young children and 2) rates of morbidity and mortality exhibit large variances across nations, locales, and even within cities. It is found that the higher the rate of pneumococcal vaccination in a nation (or city) the lower the COVID-19 morbidity and mortality. Vaccination rates with Bacillus Calmette-Guerin, poliovirus, and other vaccines do not correlate with COVID-19 risks, nor do COVID-19 case or death rates correlate with number of people in the population with diabetes, obesity, or adults over 65. Infant protection may be due to maternal antibodies and antiviral proteins in milk such as lactoferrin that are known to protect against coronavirus infections. Subsequent protection might then be conferred (and correlate with) rates of Haemophilus influenzae type B (Hib) (universal in infants) and pneumococcal vaccination, the latter varying widely by geography among infants, at-risk adults, and the elderly. Also see the video abstract here https://youtu.be/GODBYRbPL00 | ||
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