Synthesis, structural characterization and antitumor activity of six rare earth metal complexes with 8-hydroxyquinoline derivatives
Copyright © 2020 Elsevier Inc. All rights reserved..
The rare earth metal Gd(III), Yb(III), Lu(III), Eu(III), Tb(III) and Ho(III) complexes 1-6 with 2-((2-(pyridin-2-yl)hydrazono)methyl)quinolin-8-ol (H-L) as ligands were synthesized. The in vitro cytotoxicity assay indicated that the cytotoxicity of 1 was equivalent to cisplatin and higher than that of H-L and other complexes towards T24 tumor cells. The mechanism study indicated that 1 caused significant up-regulation of the proteins p27, p21 and p53 in T24 cells and cell cycle arrest in G2 phase. In addition, 1 induced effective T24 cells apoptosis via mitochondrial dysfunction pathway, which was indicated by changes in mitochondrial membrane potential (Δψ), reactive oxygen species (ROS), intracellular Ca2+ and the mitochondria-related proteins (including cytochrome C (Cyt C), B-cell lymphoma-2 (Bcl-2), Bcl-2-associated x (Bax) and apoptotic protease activating factor-1 (Apaf-1)). Moreover, 1 could activate caspase-3/8/9 in T24 cells. Therefore, complex 1 is a promising and potent anticancer drug candidate.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:211 |
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| Enthalten in: |
Journal of inorganic biochemistry - 211(2020) vom: 04. Okt., Seite 111175 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yang, Qi-Yuan [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 08.07.2021 Date Revised 08.07.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jinorgbio.2020.111175 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM314316655 |
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| 100 | 1 | |a Yang, Qi-Yuan |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Synthesis, structural characterization and antitumor activity of six rare earth metal complexes with 8-hydroxyquinoline derivatives |
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| 500 | |a Date Revised 08.07.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier Inc. All rights reserved. | ||
| 520 | |a The rare earth metal Gd(III), Yb(III), Lu(III), Eu(III), Tb(III) and Ho(III) complexes 1-6 with 2-((2-(pyridin-2-yl)hydrazono)methyl)quinolin-8-ol (H-L) as ligands were synthesized. The in vitro cytotoxicity assay indicated that the cytotoxicity of 1 was equivalent to cisplatin and higher than that of H-L and other complexes towards T24 tumor cells. The mechanism study indicated that 1 caused significant up-regulation of the proteins p27, p21 and p53 in T24 cells and cell cycle arrest in G2 phase. In addition, 1 induced effective T24 cells apoptosis via mitochondrial dysfunction pathway, which was indicated by changes in mitochondrial membrane potential (Δψ), reactive oxygen species (ROS), intracellular Ca2+ and the mitochondria-related proteins (including cytochrome C (Cyt C), B-cell lymphoma-2 (Bcl-2), Bcl-2-associated x (Bax) and apoptotic protease activating factor-1 (Apaf-1)). Moreover, 1 could activate caspase-3/8/9 in T24 cells. Therefore, complex 1 is a promising and potent anticancer drug candidate | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a 8-Hydroxyquinoline derivatives | |
| 650 | 4 | |a Apoptosis | |
| 650 | 4 | |a Cytotoxicity | |
| 650 | 4 | |a Gd(III) complex | |
| 650 | 4 | |a Rare earth metal | |
| 650 | 7 | |a Antineoplastic Agents |2 NLM | |
| 650 | 7 | |a Coordination Complexes |2 NLM | |
| 650 | 7 | |a Metals, Rare Earth |2 NLM | |
| 650 | 7 | |a Oxyquinoline |2 NLM | |
| 650 | 7 | |a 5UTX5635HP |2 NLM | |
| 650 | 7 | |a Cisplatin |2 NLM | |
| 650 | 7 | |a Q20Q21Q62J |2 NLM | |
| 700 | 1 | |a Cao, Qian-Qian |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yun-Liang |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Xiao-Fang |e verfasserin |4 aut | |
| 700 | 1 | |a Deng, Cai-Xing |e verfasserin |4 aut | |
| 700 | 1 | |a Kumar, Rajesh |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Xiao-Min |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xiu-Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Zhen-Feng |e verfasserin |4 aut | |
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