The association of diabetes and the prognosis of COVID-19 patients : A retrospective study
Copyright © 2020 Elsevier B.V. All rights reserved..
AIMS: This study evaluated the impact of previous glycemic control and in-hospital use of antidiabetic/antihypertensive drugs on the prognosis of COVID-19 patients with diabetes.
METHODS: In this retrospective cohort study, consecutive inpatients with laboratory confirmed COVID-19 were enrolled from Tongji Hospital (Wuhan, China). Patients without diabetes were matched to those with diabetes based on age, sex, and comorbidities. All patients were followed up to a clinical endpoint (discharge, worsening including transferring to ICU or immediate death). Data and outcomes were extracted from medical records and analyzed.
RESULTS: 64 patients with pre-existing diabetes were included in this study, with 128 matched patients without diabetes included as a control group. Patients with diabetes had a higher rate of worsening (18.8% versus 7.8%, p = 0.025). Multivariable regression showed increased odds of worsening associated with previous glycemic control reflected by HbA1c (odds ratio 3.29, 95% CI 1.19-9.13, p = 0.022) and receiver-operating characteristics (ROC) curve identified HbA1c of 8.6% (70 mmol/mol) as the optimal cut-off value. Univariate analysis demonstrated the in-hospital use of antidiabetic/antihypertensive drugs were not associated with a higher risk of worsening.
CONCLUSIONS: COVID-19 patients with diabetes had a higher risk of worsening, especially those with poorly-controlled HbA1c, with an optimal cut-off value of 8.6%. The in-hospital use of antidiabetic/antihypertensive drugs were not associated with increased odds of worsening in patients with diabetes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:169 |
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| Enthalten in: |
Diabetes research and clinical practice - 169(2020) vom: 01. Nov., Seite 108386 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Zhelong [VerfasserIn] |
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| Links: |
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| Themen: |
Antidiabetic drugs |
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| Anmerkungen: |
Date Completed 29.12.2020 Date Revised 15.07.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.diabres.2020.108386 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM314269347 |
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| 100 | 1 | |a Liu, Zhelong |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The association of diabetes and the prognosis of COVID-19 patients |b A retrospective study |
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| 500 | |a Date Completed 29.12.2020 | ||
| 500 | |a Date Revised 15.07.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier B.V. All rights reserved. | ||
| 520 | |a AIMS: This study evaluated the impact of previous glycemic control and in-hospital use of antidiabetic/antihypertensive drugs on the prognosis of COVID-19 patients with diabetes | ||
| 520 | |a METHODS: In this retrospective cohort study, consecutive inpatients with laboratory confirmed COVID-19 were enrolled from Tongji Hospital (Wuhan, China). Patients without diabetes were matched to those with diabetes based on age, sex, and comorbidities. All patients were followed up to a clinical endpoint (discharge, worsening including transferring to ICU or immediate death). Data and outcomes were extracted from medical records and analyzed | ||
| 520 | |a RESULTS: 64 patients with pre-existing diabetes were included in this study, with 128 matched patients without diabetes included as a control group. Patients with diabetes had a higher rate of worsening (18.8% versus 7.8%, p = 0.025). Multivariable regression showed increased odds of worsening associated with previous glycemic control reflected by HbA1c (odds ratio 3.29, 95% CI 1.19-9.13, p = 0.022) and receiver-operating characteristics (ROC) curve identified HbA1c of 8.6% (70 mmol/mol) as the optimal cut-off value. Univariate analysis demonstrated the in-hospital use of antidiabetic/antihypertensive drugs were not associated with a higher risk of worsening | ||
| 520 | |a CONCLUSIONS: COVID-19 patients with diabetes had a higher risk of worsening, especially those with poorly-controlled HbA1c, with an optimal cut-off value of 8.6%. The in-hospital use of antidiabetic/antihypertensive drugs were not associated with increased odds of worsening in patients with diabetes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Antidiabetic drugs | |
| 650 | 4 | |a Antihypertensive drugs | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Diabetes | |
| 650 | 4 | |a HbA1c | |
| 650 | 7 | |a Antihypertensive Agents |2 NLM | |
| 650 | 7 | |a Hypoglycemic Agents |2 NLM | |
| 700 | 1 | |a Bai, Xi |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Xia |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Wangyan |e verfasserin |4 aut | |
| 700 | 1 | |a Qiu, Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Shi |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Xuefeng |e verfasserin |4 aut | |
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