A Chromosomal Inversion of 46XX, inv (6) (p21.3p23) Connects to Congenital Heart Defects
Copyright © 2020 Cheng, Tang, Lin, Ba, Ding, Chen, Liu, Pan, Qin and Huang..
Congenital heart defects (CHDs) represent the most common human birth defects. Ventricular septal defect (VSD) is the most common subtype of CHDs. It has been shown that about 20-40% of VSDs are closely related to chromosomal aneuploidies or Mendelian diseases. In this study, we report a pedigree with VSD associated with a balanced paracentric inversion of chromosome 6, inv (6)(p21.3p23), a rarely reported CHD-associated chromosomal abnormality related to the fragile site at 6p23. We have found that the major clinical features of the proband include CHDs (ventricular septal defect, severe pulmonary hypertension, tricuspid regurgitation, and patent foramen ovale), severe pneumonia, and growth retardation. Our study reports a rare chromosomal abnormality connected to CHDs, which may represent a new genetic etiology for VSD.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
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| Enthalten in: |
Frontiers in cardiovascular medicine - 7(2020) vom: 18., Seite 121 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cheng, Liangping [VerfasserIn] |
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| Links: |
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| Themen: |
Case Reports |
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| Anmerkungen: |
Date Revised 28.09.2020 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fcvm.2020.00121 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM314242740 |
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| 520 | |a Copyright © 2020 Cheng, Tang, Lin, Ba, Ding, Chen, Liu, Pan, Qin and Huang. | ||
| 520 | |a Congenital heart defects (CHDs) represent the most common human birth defects. Ventricular septal defect (VSD) is the most common subtype of CHDs. It has been shown that about 20-40% of VSDs are closely related to chromosomal aneuploidies or Mendelian diseases. In this study, we report a pedigree with VSD associated with a balanced paracentric inversion of chromosome 6, inv (6)(p21.3p23), a rarely reported CHD-associated chromosomal abnormality related to the fragile site at 6p23. We have found that the major clinical features of the proband include CHDs (ventricular septal defect, severe pulmonary hypertension, tricuspid regurgitation, and patent foramen ovale), severe pneumonia, and growth retardation. Our study reports a rare chromosomal abnormality connected to CHDs, which may represent a new genetic etiology for VSD | ||
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| 650 | 4 | |a ventricular septal defect | |
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| 700 | 1 | |a Lin, Yuese |e verfasserin |4 aut | |
| 700 | 1 | |a Ba, Hongjun |e verfasserin |4 aut | |
| 700 | 1 | |a Ding, Yiqian |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Dubo |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Min |e verfasserin |4 aut | |
| 700 | 1 | |a Pan, Peizhen |e verfasserin |4 aut | |
| 700 | 1 | |a Qin, Youzhen |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Zhan-Peng |e verfasserin |4 aut | |
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