Association between PTGER4 polymorphisms and inflammatory bowel disease risk in Caucasian : A meta-analysis
BACKGROUND: The results from previous studies on association between prostaglandin E receptor 4 (PTGER4) polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian were conflict. The present study aimed to investigate the genetic association by conducting a meta-analysis.
METHODS: Systematic literature search was conducted through Wiley Online Library, Chinese National Knowledge Infrastructure (CNKI), and PubMed databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to investigate the associations between rs4613763 T/C, 17234657T/G polymorphisms, and IBD risk in Caucasian.
RESULTS: Twenty case-control studies consisting of 18,495 Crohn disease (CD) patients and 4203 ulcerative colitis (UC) patients, as well as 26,063 controls were included in this meta-analysis. The rs4613763T/C polymorphism had obvious influence on CD, UC risk in Caucasian. However, rs17234657T/G polymorphism had obvious influence on CD but not UC in Caucasian.
CONCLUSION: This meta-analysis suggested that both the rs4613763 T/C, rs17234657T/G polymorphisms had obvious influence on risk of CD in Caucasian. In addition, rs4613763 T/C, polymorphism had obvious influence on risk of UC in Caucasian.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:99 |
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| Enthalten in: |
Medicine - 99(2020), 34 vom: 21. Aug., Seite e19756 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wu, Peng-Bo [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 08.09.2020 Date Revised 07.12.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1097/MD.0000000000019756 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM314200509 |
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| 100 | 1 | |a Wu, Peng-Bo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Association between PTGER4 polymorphisms and inflammatory bowel disease risk in Caucasian |b A meta-analysis |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Completed 08.09.2020 | ||
| 500 | |a Date Revised 07.12.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: The results from previous studies on association between prostaglandin E receptor 4 (PTGER4) polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian were conflict. The present study aimed to investigate the genetic association by conducting a meta-analysis | ||
| 520 | |a METHODS: Systematic literature search was conducted through Wiley Online Library, Chinese National Knowledge Infrastructure (CNKI), and PubMed databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to investigate the associations between rs4613763 T/C, 17234657T/G polymorphisms, and IBD risk in Caucasian | ||
| 520 | |a RESULTS: Twenty case-control studies consisting of 18,495 Crohn disease (CD) patients and 4203 ulcerative colitis (UC) patients, as well as 26,063 controls were included in this meta-analysis. The rs4613763T/C polymorphism had obvious influence on CD, UC risk in Caucasian. However, rs17234657T/G polymorphism had obvious influence on CD but not UC in Caucasian | ||
| 520 | |a CONCLUSION: This meta-analysis suggested that both the rs4613763 T/C, rs17234657T/G polymorphisms had obvious influence on risk of CD in Caucasian. In addition, rs4613763 T/C, polymorphism had obvious influence on risk of UC in Caucasian | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Systematic Review | |
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| 650 | 7 | |a Receptors, Prostaglandin E, EP4 Subtype |2 NLM | |
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| 700 | 1 | |a Hong, Chai |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Yi-Tian |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Yuan-Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Guo |e verfasserin |4 aut | |
| 700 | 1 | |a Tan, Shi-Yun |e verfasserin |4 aut | |
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