Improvement in host metabolic homeostasis and alteration in gut microbiota in mice on the high-fat diet : A comparison of calcium supplements
Copyright © 2020 Elsevier Ltd. All rights reserved..
Despite the previously reported health benefits of calcium intake for the attenuation of metabolic disease, few studies have investigated the relationships among calcium intake, gut microbiota, and host metabolism. In this study, we assessed the effects of calcium supplementation on host microbial community composition and metabolic homeostasis. Mice were fed a high-fat diet with different calcium concentrations (4 and 12 g/kg) of 2 calcium supplements, calcium carbonate and calcium citrate. Supplementation with the higher concentration of calcium citrate significantly prevented body weight gain and decreased plasma biomarkers for metabolic disorder compared to calcium carbonate supplementation. Both calcium supplementation led to changes in microbial composition, increased propionate production and increased anorexigenic GLP-1 gene expression. The calcium citrate groups also experienced less metabolic endotoxemia. Our findings suggested that calcium supplementation could ameliorate host metabolic disorder caused by a high-fat diet, due to gut microbiota changes as well as decreased intestinal inflammation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:136 |
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| Enthalten in: |
Food research international (Ottawa, Ont.) - 136(2020) vom: 15. Okt., Seite 109495 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cha, Kwang Hyun [VerfasserIn] |
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| Links: |
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| Themen: |
Calcium |
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| Anmerkungen: |
Date Completed 14.05.2021 Date Revised 14.05.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.foodres.2020.109495 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM314198784 |
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| 100 | 1 | |a Cha, Kwang Hyun |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Improvement in host metabolic homeostasis and alteration in gut microbiota in mice on the high-fat diet |b A comparison of calcium supplements |
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| 500 | |a Date Revised 14.05.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier Ltd. All rights reserved. | ||
| 520 | |a Despite the previously reported health benefits of calcium intake for the attenuation of metabolic disease, few studies have investigated the relationships among calcium intake, gut microbiota, and host metabolism. In this study, we assessed the effects of calcium supplementation on host microbial community composition and metabolic homeostasis. Mice were fed a high-fat diet with different calcium concentrations (4 and 12 g/kg) of 2 calcium supplements, calcium carbonate and calcium citrate. Supplementation with the higher concentration of calcium citrate significantly prevented body weight gain and decreased plasma biomarkers for metabolic disorder compared to calcium carbonate supplementation. Both calcium supplementation led to changes in microbial composition, increased propionate production and increased anorexigenic GLP-1 gene expression. The calcium citrate groups also experienced less metabolic endotoxemia. Our findings suggested that calcium supplementation could ameliorate host metabolic disorder caused by a high-fat diet, due to gut microbiota changes as well as decreased intestinal inflammation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Calcium carbonate | |
| 650 | 4 | |a Calcium citrate | |
| 650 | 4 | |a Gut microbiota | |
| 650 | 4 | |a In vivo mice experiment | |
| 650 | 4 | |a Metabolic homeostasis | |
| 650 | 7 | |a Calcium |2 NLM | |
| 650 | 7 | |a SY7Q814VUP |2 NLM | |
| 700 | 1 | |a Yang, Jung-Seok |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Kyung-A |e verfasserin |4 aut | |
| 700 | 1 | |a Yoon, Kye-Yoon |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Dae-Geun |e verfasserin |4 aut | |
| 700 | 1 | |a Erdene-Ochir, Erdenedolgor |e verfasserin |4 aut | |
| 700 | 1 | |a Kang, Kyungsu |e verfasserin |4 aut | |
| 700 | 1 | |a Pan, Cheol-Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Ko, GwangPyo |e verfasserin |4 aut | |
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