Bone-Specific Drug Delivery for Osteoporosis and Rare Skeletal Disorders
PURPOSE OF REVIEW: The skeletal system provides an important role to support body structure and protect organs. The complexity of its architecture and components makes it challenging to deliver the right amount of the drug into bone regions, particularly avascular cartilage lesions. In this review, we describe the recent advance of bone-targeting methods using bisphosphonates, polymeric oligopeptides, and nanoparticles on osteoporosis and rare skeletal diseases.
RECENT FINDINGS: Hydroxyapatite (HA), a calcium phosphate with the formula Ca10(PO4)6(OH)2, is a primary matrix of bone mineral that includes a high concentration of positively charged calcium ion and is found only in the bone. This unique feature makes HA a general targeting moiety to the entire skeletal system. We have applied bone-targeting strategy using acidic amino acid oligopeptides into lysosomal enzymes, demonstrating the effects of bone-targeting enzyme replacement therapy and gene therapy on bone and cartilage lesions in inherited skeletal disorders. Virus or no-virus gene therapy using techniques of engineered capsid or nanomedicine has been studied preclinically for skeletal diseases. Efficient drug delivery into bone lesions remains an unmet challenge in clinical practice. Bone-targeting therapies based on gene transfer can be potential as new candidates for skeletal diseases.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2020 |
---|---|
Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
---|---|
Enthalten in: |
Current osteoporosis reports - 18(2020), 5 vom: 26. Okt., Seite 515-525 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Sawamoto, Kazuki [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 25.10.2021 Date Revised 11.02.2024 published: Print Citation Status MEDLINE |
---|
doi: |
10.1007/s11914-020-00620-4 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM314187790 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM314187790 | ||
003 | DE-627 | ||
005 | 20240211231833.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2020 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s11914-020-00620-4 |2 doi | |
028 | 5 | 2 | |a pubmed24n1288.xml |
035 | |a (DE-627)NLM314187790 | ||
035 | |a (NLM)32845464 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Sawamoto, Kazuki |e verfasserin |4 aut | |
245 | 1 | 0 | |a Bone-Specific Drug Delivery for Osteoporosis and Rare Skeletal Disorders |
264 | 1 | |c 2020 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 25.10.2021 | ||
500 | |a Date Revised 11.02.2024 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a PURPOSE OF REVIEW: The skeletal system provides an important role to support body structure and protect organs. The complexity of its architecture and components makes it challenging to deliver the right amount of the drug into bone regions, particularly avascular cartilage lesions. In this review, we describe the recent advance of bone-targeting methods using bisphosphonates, polymeric oligopeptides, and nanoparticles on osteoporosis and rare skeletal diseases | ||
520 | |a RECENT FINDINGS: Hydroxyapatite (HA), a calcium phosphate with the formula Ca10(PO4)6(OH)2, is a primary matrix of bone mineral that includes a high concentration of positively charged calcium ion and is found only in the bone. This unique feature makes HA a general targeting moiety to the entire skeletal system. We have applied bone-targeting strategy using acidic amino acid oligopeptides into lysosomal enzymes, demonstrating the effects of bone-targeting enzyme replacement therapy and gene therapy on bone and cartilage lesions in inherited skeletal disorders. Virus or no-virus gene therapy using techniques of engineered capsid or nanomedicine has been studied preclinically for skeletal diseases. Efficient drug delivery into bone lesions remains an unmet challenge in clinical practice. Bone-targeting therapies based on gene transfer can be potential as new candidates for skeletal diseases | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, N.I.H., Extramural | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Review | |
650 | 4 | |a Acidic amino acid oligopeptide | |
650 | 4 | |a Bone-targeting | |
650 | 4 | |a Metabolic rare skeletal disorders | |
650 | 4 | |a Nanoparticles | |
650 | 4 | |a Osteoporosis | |
650 | 7 | |a Amino Acids, Acidic |2 NLM | |
650 | 7 | |a Bone Density Conservation Agents |2 NLM | |
650 | 7 | |a Diphosphonates |2 NLM | |
650 | 7 | |a Oligopeptides |2 NLM | |
650 | 7 | |a Parathyroid Hormone |2 NLM | |
650 | 7 | |a Calcitonin |2 NLM | |
650 | 7 | |a 9007-12-9 |2 NLM | |
650 | 7 | |a Durapatite |2 NLM | |
650 | 7 | |a 91D9GV0Z28 |2 NLM | |
650 | 7 | |a ALPL protein, human |2 NLM | |
650 | 7 | |a EC 3.1.3.1 |2 NLM | |
650 | 7 | |a Alkaline Phosphatase |2 NLM | |
650 | 7 | |a EC 3.1.3.1 |2 NLM | |
650 | 7 | |a Chondroitinsulfatases |2 NLM | |
650 | 7 | |a EC 3.1.6.- |2 NLM | |
650 | 7 | |a GALNS protein, human |2 NLM | |
650 | 7 | |a EC 3.1.6.4 |2 NLM | |
700 | 1 | |a Álvarez, J Víctor |e verfasserin |4 aut | |
700 | 1 | |a Herreño, Angélica María |e verfasserin |4 aut | |
700 | 1 | |a Otero-Espinar, Francisco J |e verfasserin |4 aut | |
700 | 1 | |a Couce, Maria L |e verfasserin |4 aut | |
700 | 1 | |a Alméciga-Díaz, Carlos J |e verfasserin |4 aut | |
700 | 1 | |a Tomatsu, Shunji |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Current osteoporosis reports |d 2003 |g 18(2020), 5 vom: 26. Okt., Seite 515-525 |w (DE-627)NLM156716704 |x 1544-2241 |7 nnns |
773 | 1 | 8 | |g volume:18 |g year:2020 |g number:5 |g day:26 |g month:10 |g pages:515-525 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/s11914-020-00620-4 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 18 |j 2020 |e 5 |b 26 |c 10 |h 515-525 |