Association between short-term exposure to ambient particulate air pollution and biomarkers of oxidative stress : A meta-analysis
Copyright © 2020 Elsevier Inc. All rights reserved..
BACKGROUND: Exposure to ambient particulate air pollution contributes substantially to the mortality and morbidity due to cardiovascular diseases (CVD), respiratory diseases and neurodegenerative diseases. Several hypothetical mechanisms have been proposed to explain these associations, particularly oxidative stress. Malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and Superoxide Dismutase (SOD) are typical biomarkers of oxidative stress and have been frequently investigated. However, the association between exposure to ambient particulate matter (PM) and these biomarkers has not been well established.
OBJECTIVES: Evaluate the association between ambient particulate air pollution and biomarkers of oxidative stress based on existing epidemiological studies.
METHODS: A systematic literature search was conducted in databases of Science Direct, PubMed, Web of Science, and Scopus up to April 24, 2020 to summarize epidemiological studies reporting the association between exposure to ambient PM (PM2.5, PM10, or both) and biomarkers of oxidative stress, and a meta-analysis was performed for the associations reported in individual studies using a random-effect model.
RESULTS: This meta-analysis included 23 epidemiological studies (13 identified for 8-OHdG, 11 identified for MDA and 5 identified for SOD). A 10 μg/m3 increase in short-term exposure to ambient PM2.5 was associated with pooled percent changes of 2.10% (95% CIs: -0.13%, 4.38%), 1.60% (95% CIs: 0.21%, 3.01%) and -0.61% (95% CIs: -1.92%, 0.72%) in 8-OHdG, MDA and SOD, respectively.
CONCLUSION: Short-term exposure to ambient PM2.5 was associated with a significantly increased level of MDA, indicating that ambient particulate air pollution may contribute to increased oxidative stress.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:191 |
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| Enthalten in: |
Environmental research - 191(2020) vom: 15. Dez., Seite 110105 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Zichuan [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 11.01.2021 Date Revised 31.05.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.envres.2020.110105 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a Date Revised 31.05.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Exposure to ambient particulate air pollution contributes substantially to the mortality and morbidity due to cardiovascular diseases (CVD), respiratory diseases and neurodegenerative diseases. Several hypothetical mechanisms have been proposed to explain these associations, particularly oxidative stress. Malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and Superoxide Dismutase (SOD) are typical biomarkers of oxidative stress and have been frequently investigated. However, the association between exposure to ambient particulate matter (PM) and these biomarkers has not been well established | ||
| 520 | |a OBJECTIVES: Evaluate the association between ambient particulate air pollution and biomarkers of oxidative stress based on existing epidemiological studies | ||
| 520 | |a METHODS: A systematic literature search was conducted in databases of Science Direct, PubMed, Web of Science, and Scopus up to April 24, 2020 to summarize epidemiological studies reporting the association between exposure to ambient PM (PM2.5, PM10, or both) and biomarkers of oxidative stress, and a meta-analysis was performed for the associations reported in individual studies using a random-effect model | ||
| 520 | |a RESULTS: This meta-analysis included 23 epidemiological studies (13 identified for 8-OHdG, 11 identified for MDA and 5 identified for SOD). A 10 μg/m3 increase in short-term exposure to ambient PM2.5 was associated with pooled percent changes of 2.10% (95% CIs: -0.13%, 4.38%), 1.60% (95% CIs: 0.21%, 3.01%) and -0.61% (95% CIs: -1.92%, 0.72%) in 8-OHdG, MDA and SOD, respectively | ||
| 520 | |a CONCLUSION: Short-term exposure to ambient PM2.5 was associated with a significantly increased level of MDA, indicating that ambient particulate air pollution may contribute to increased oxidative stress | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a 8-Hydroxy-2′-deoxyguanosine | |
| 650 | 4 | |a Malondialdehyde | |
| 650 | 4 | |a Oxidative stress | |
| 650 | 4 | |a Particulate air pollution | |
| 650 | 4 | |a Superoxide dismutase | |
| 650 | 7 | |a Air Pollutants |2 NLM | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a Particulate Matter |2 NLM | |
| 700 | 1 | |a Liu, Qisijing |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Zhouyang |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Xinbiao |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Shaowei |e verfasserin |4 aut | |
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