Phosphofructokinase-M inhibits cell growth via modulating the FOXO3 pathway in renal cell carcinoma cells
Copyright © 2020 Elsevier Inc. All rights reserved..
Phosphofructokinase-M (PFKM) is a key enzyme in glycolysis. The expression and activity of PFKM is closely related to the occurrence and development of malignant tumors, but its role in the regulation of renal cell carcinoma (RCC) is still unknown. We found that the expression of PFKM was lower in RCC tumor tissue than in adjacent normal tissues, and that low expression of PFKM was related to the poor overall survival of RCC patients. In addition, our results showed that FOXO3 mediated PFKM inhibited the growth, migration and invasion of RCC cells, suggesting that PFKM is a protective factor for RCC.
| Errataetall: |
RetractionIn: Biochem Biophys Res Commun. 2024 Mar 15;701:149619. - PMID 38325178 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:530 |
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| Enthalten in: |
Biochemical and biophysical research communications - 530(2020), 1 vom: 10. Sept., Seite 67-74 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chen, Yeda [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 24.02.2021 Date Revised 22.02.2024 published: Print-Electronic RetractionIn: Biochem Biophys Res Commun. 2024 Mar 15;701:149619. - PMID 38325178 Citation Status MEDLINE |
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| doi: |
10.1016/j.bbrc.2020.06.062 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM314019537 |
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| 500 | |a RetractionIn: Biochem Biophys Res Commun. 2024 Mar 15;701:149619. - PMID 38325178 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier Inc. All rights reserved. | ||
| 520 | |a Phosphofructokinase-M (PFKM) is a key enzyme in glycolysis. The expression and activity of PFKM is closely related to the occurrence and development of malignant tumors, but its role in the regulation of renal cell carcinoma (RCC) is still unknown. We found that the expression of PFKM was lower in RCC tumor tissue than in adjacent normal tissues, and that low expression of PFKM was related to the poor overall survival of RCC patients. In addition, our results showed that FOXO3 mediated PFKM inhibited the growth, migration and invasion of RCC cells, suggesting that PFKM is a protective factor for RCC | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Retracted Publication | |
| 650 | 4 | |a FOXO3 | |
| 650 | 4 | |a Growth | |
| 650 | 4 | |a Invasion | |
| 650 | 4 | |a Migration | |
| 650 | 4 | |a Phosphofructokinase-M | |
| 650 | 4 | |a Renal cell carcinoma | |
| 650 | 7 | |a FOXO3 protein, human |2 NLM | |
| 650 | 7 | |a Forkhead Box Protein O3 |2 NLM | |
| 650 | 7 | |a Phosphofructokinase-1, Muscle Type |2 NLM | |
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| 650 | 7 | |a PFKM protein, human |2 NLM | |
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| 700 | 1 | |a Yu, Qingfeng |e verfasserin |4 aut | |
| 700 | 1 | |a Duan, Xiaolu |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Wenqi |e verfasserin |4 aut | |
| 700 | 1 | |a Zeng, Guohua |e verfasserin |4 aut | |
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