Epidemiological and clinical characteristics of SARS-CoV-2 infections at a testing site in Berlin, Germany, March and April 2020-a cross-sectional study
Copyright © 2020. Published by Elsevier Ltd..
OBJECTIVE: In Berlin, the first public severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing site started 1 day after the first case in the city occurred. We describe epidemiological and clinical characteristics and aim at identifying risk factors for SARS-CoV-2 detection during the first 6 weeks of operation.
METHODS: Testing followed national recommendations, but was also based on the physician's discretion. We related patient characteristics to SARS-CoV-2 test positivity for exploratory analyses using a cross-sectional, observational study design.
RESULTS: Between 3 March and 13 April 2020, 5179 individuals attended the site (median age 34 years; interquartile range 26-47 years). The median time since disease onset was 4 days (interquartile range 2-7 days). Among 4333 persons tested, 333 (7.7%) were positive. Test positivity increased up to 10.3% (96/929) during the first 3 weeks and then declined, paralleling Germany's lock-down and the course of the epidemic in Berlin. Strict adherence to testing guidelines resulted in 10.4% (262/2530) test positivity, compared with 3.9% (71/1803) among individuals tested for other indications. A nightclub was a transmission hotspot; 27.7% (26/94) of one night's visitors were found positive. Smell and/or taste dysfunction indicated coronavirus disease 2019 (COVID-19) with 85.6% specificity (95% CI 82.1%-88.1%). Four per cent (14/333) of those infected were asymptomatic. Risk factors for detection of SARS-CoV-2 infection were recent contact with a positive case (second week after contact, OR 3.42; 95% CI 2.48-4.71), travel to regions of high pandemic activity (e.g. Austria, OR 4.16; 95% CI 2.48-6.99), recent onset of symptoms (second week, OR 3.61; 95% CI 1.87-6.98) and an impaired sense of smell/taste (4.08; 95% CI 2.36-7.03).
CONCLUSIONS: In this young population, early-onset presentation of COVID-19 resembled flu-like symptoms, except for smell and/or taste dysfunction. Risk factors for SARS-CoV-2 detection were return from regions with high incidence and contact with confirmed SARS-CoV-2 cases, particularly when tests were administered within the first 2 weeks after contact and/or onset of symptoms.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 26(2020), 12 vom: 15. Dez., Seite 1685.e7-1685.e12 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Maechler, Friederike [VerfasserIn] |
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| Links: |
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| Themen: |
Asymptomatic |
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| Anmerkungen: |
Date Completed 09.12.2020 Date Revised 10.01.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.cmi.2020.08.017 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM314013563 |
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| 100 | 1 | |a Maechler, Friederike |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Epidemiological and clinical characteristics of SARS-CoV-2 infections at a testing site in Berlin, Germany, March and April 2020-a cross-sectional study |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 09.12.2020 | ||
| 500 | |a Date Revised 10.01.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020. Published by Elsevier Ltd. | ||
| 520 | |a OBJECTIVE: In Berlin, the first public severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing site started 1 day after the first case in the city occurred. We describe epidemiological and clinical characteristics and aim at identifying risk factors for SARS-CoV-2 detection during the first 6 weeks of operation | ||
| 520 | |a METHODS: Testing followed national recommendations, but was also based on the physician's discretion. We related patient characteristics to SARS-CoV-2 test positivity for exploratory analyses using a cross-sectional, observational study design | ||
| 520 | |a RESULTS: Between 3 March and 13 April 2020, 5179 individuals attended the site (median age 34 years; interquartile range 26-47 years). The median time since disease onset was 4 days (interquartile range 2-7 days). Among 4333 persons tested, 333 (7.7%) were positive. Test positivity increased up to 10.3% (96/929) during the first 3 weeks and then declined, paralleling Germany's lock-down and the course of the epidemic in Berlin. Strict adherence to testing guidelines resulted in 10.4% (262/2530) test positivity, compared with 3.9% (71/1803) among individuals tested for other indications. A nightclub was a transmission hotspot; 27.7% (26/94) of one night's visitors were found positive. Smell and/or taste dysfunction indicated coronavirus disease 2019 (COVID-19) with 85.6% specificity (95% CI 82.1%-88.1%). Four per cent (14/333) of those infected were asymptomatic. Risk factors for detection of SARS-CoV-2 infection were recent contact with a positive case (second week after contact, OR 3.42; 95% CI 2.48-4.71), travel to regions of high pandemic activity (e.g. Austria, OR 4.16; 95% CI 2.48-6.99), recent onset of symptoms (second week, OR 3.61; 95% CI 1.87-6.98) and an impaired sense of smell/taste (4.08; 95% CI 2.36-7.03) | ||
| 520 | |a CONCLUSIONS: In this young population, early-onset presentation of COVID-19 resembled flu-like symptoms, except for smell and/or taste dysfunction. Risk factors for SARS-CoV-2 detection were return from regions with high incidence and contact with confirmed SARS-CoV-2 cases, particularly when tests were administered within the first 2 weeks after contact and/or onset of symptoms | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Asymptomatic | |
| 650 | 4 | |a Coronavirus | |
| 650 | 4 | |a Coronavirus disease 2019 | |
| 650 | 4 | |a Olfaction disorders | |
| 650 | 4 | |a Screening | |
| 650 | 4 | |a Severe acute respiratory syndrome coronavirus 2 | |
| 700 | 1 | |a Gertler, Maximilian |e verfasserin |4 aut | |
| 700 | 1 | |a Hermes, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a van Loon, Welmoed |e verfasserin |4 aut | |
| 700 | 1 | |a Schwab, Frank |e verfasserin |4 aut | |
| 700 | 1 | |a Piening, Brar |e verfasserin |4 aut | |
| 700 | 1 | |a Rojansky, Shay |e verfasserin |4 aut | |
| 700 | 1 | |a Hommes, Franziska |e verfasserin |4 aut | |
| 700 | 1 | |a Kausch, Franka |e verfasserin |4 aut | |
| 700 | 1 | |a Lindner, Andreas K |e verfasserin |4 aut | |
| 700 | 1 | |a Burock, Susen |e verfasserin |4 aut | |
| 700 | 1 | |a Rössig, Heike |e verfasserin |4 aut | |
| 700 | 1 | |a Hartmann, Claudia |e verfasserin |4 aut | |
| 700 | 1 | |a Kirchberger, Valerie |e verfasserin |4 aut | |
| 700 | 1 | |a Thieme, Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Behnke, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Gastmeier, Petra |e verfasserin |4 aut | |
| 700 | 1 | |a Mockenhaupt, Frank P |e verfasserin |4 aut | |
| 700 | 1 | |a Seybold, Joachim |e verfasserin |4 aut | |
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