SHED promote angiogenesis in stem cell-mediated dental pulp regeneration
Copyright © 2020 Elsevier Inc. All rights reserved..
Dental pulp, plays an indispensable role in maintaining homeostasis of the tooth. Pulp necrosis always causes tooth nutrition deficiency and abnormal root development, which leads to tooth discoloration, fracture or even loss. Our previous study showed implantation of autologous SHED could regenerate functional dental pulp. However, the detailed mechanism of the implanted SHED participating in dental pulp regeneration remains unknown. In this study, we implanted SHED in a porcine dental pulp regeneration model to evaluate the regenerative effect and identify whether SHED promoted angiogenesis in regenerated dental pulp. Firstly we verified that xenogenous SHED had the ability to regenerated pulp tissue of host in vivo. Then we found the vasculature in regenerated pulp originated from implanted SHED. In addition, stem cells were isolated from regenerated dental pulp, which exhibited good multi-differentiation properties and promoted angiogenesis in pulp regeneration process and these results demonstrated that SHED promoted angiogenesis in stem cell-mediated dental pulp regeneration.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:529 |
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| Enthalten in: |
Biochemical and biophysical research communications - 529(2020), 4 vom: 03. Sept., Seite 1158-1164 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Guo, Hao [VerfasserIn] |
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| Links: |
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| Themen: |
Angiogenesis |
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| Anmerkungen: |
Date Completed 11.02.2021 Date Revised 11.02.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bbrc.2020.06.151 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM313933804 |
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| 520 | |a Copyright © 2020 Elsevier Inc. All rights reserved. | ||
| 520 | |a Dental pulp, plays an indispensable role in maintaining homeostasis of the tooth. Pulp necrosis always causes tooth nutrition deficiency and abnormal root development, which leads to tooth discoloration, fracture or even loss. Our previous study showed implantation of autologous SHED could regenerate functional dental pulp. However, the detailed mechanism of the implanted SHED participating in dental pulp regeneration remains unknown. In this study, we implanted SHED in a porcine dental pulp regeneration model to evaluate the regenerative effect and identify whether SHED promoted angiogenesis in regenerated dental pulp. Firstly we verified that xenogenous SHED had the ability to regenerated pulp tissue of host in vivo. Then we found the vasculature in regenerated pulp originated from implanted SHED. In addition, stem cells were isolated from regenerated dental pulp, which exhibited good multi-differentiation properties and promoted angiogenesis in pulp regeneration process and these results demonstrated that SHED promoted angiogenesis in stem cell-mediated dental pulp regeneration | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Angiogenesis | |
| 650 | 4 | |a Dental pulp regeneration | |
| 700 | 1 | |a Zhao, Wanmin |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Anqi |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Meiling |e verfasserin |4 aut | |
| 700 | 1 | |a Shuai, Yi |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Bei |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Xiaoyao |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xuemei |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Xiaoxue |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Xiaohe |e verfasserin |4 aut | |
| 700 | 1 | |a Xuan, Kun |e verfasserin |4 aut | |
| 700 | 1 | |a Jin, Yan |e verfasserin |4 aut | |
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