Respiratory Syncytial Virus-Associated Hospital Admissions in Children Younger Than 5 Years in 7 European Countries Using Routinely Collected Datasets
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissionsoup.com..
BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infection (RTI) in young children. Registries provide opportunities to explore RSV epidemiology and burden.
METHODS: We explored routinely collected hospital data on RSV in children aged < 5 years in 7 European countries. We compare RSV-associated admission rates, age, seasonality, and time trends between countries.
RESULTS: We found similar age distributions of RSV-associated hospital admissions in each country, with the highest burden in children < 1 years old and peak at age 1 month. Average annual rates of RTI admission were 41.3-112.0 per 1000 children aged < 1 year and 8.6-22.3 per 1000 children aged < 1 year. In children aged < 5 years, 57%-72% of RTI admissions with specified causal pathogen were coded as RSV, with 62%-87% of pathogen-coded admissions in children < 1 year coded as RSV.
CONCLUSIONS: Our results demonstrate the benefits and limitations of using linked routinely collected data to explore epidemiology and burden of RSV. Our future work will use these data to generate estimates of RSV burden using time-series modelling methodology, to inform policymaking and regulatory decisions regarding RSV immunization strategy and monitor the impact of future vaccines.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:222 |
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| Enthalten in: |
The Journal of infectious diseases - 222(2020), Suppl 7 vom: 07. Okt., Seite S599-S605 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Reeves, Rachel M [VerfasserIn] |
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| Links: |
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| Themen: |
Europe |
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| Anmerkungen: |
Date Completed 15.03.2021 Date Revised 15.03.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/infdis/jiaa360 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM313894183 |
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| 245 | 1 | 0 | |a Respiratory Syncytial Virus-Associated Hospital Admissions in Children Younger Than 5 Years in 7 European Countries Using Routinely Collected Datasets |
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| 500 | |a Date Completed 15.03.2021 | ||
| 500 | |a Date Revised 15.03.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissionsoup.com. | ||
| 520 | |a BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infection (RTI) in young children. Registries provide opportunities to explore RSV epidemiology and burden | ||
| 520 | |a METHODS: We explored routinely collected hospital data on RSV in children aged < 5 years in 7 European countries. We compare RSV-associated admission rates, age, seasonality, and time trends between countries | ||
| 520 | |a RESULTS: We found similar age distributions of RSV-associated hospital admissions in each country, with the highest burden in children < 1 years old and peak at age 1 month. Average annual rates of RTI admission were 41.3-112.0 per 1000 children aged < 1 year and 8.6-22.3 per 1000 children aged < 1 year. In children aged < 5 years, 57%-72% of RTI admissions with specified causal pathogen were coded as RSV, with 62%-87% of pathogen-coded admissions in children < 1 year coded as RSV | ||
| 520 | |a CONCLUSIONS: Our results demonstrate the benefits and limitations of using linked routinely collected data to explore epidemiology and burden of RSV. Our future work will use these data to generate estimates of RSV burden using time-series modelling methodology, to inform policymaking and regulatory decisions regarding RSV immunization strategy and monitor the impact of future vaccines | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Europe | |
| 650 | 4 | |a RSV | |
| 650 | 4 | |a hospital admissions | |
| 650 | 4 | |a national registry data | |
| 650 | 4 | |a respiratory syncytial virus | |
| 700 | 1 | |a van Wijhe, Maarten |e verfasserin |4 aut | |
| 700 | 1 | |a Tong, Sabine |e verfasserin |4 aut | |
| 700 | 1 | |a Lehtonen, Toni |e verfasserin |4 aut | |
| 700 | 1 | |a Stona, Luca |e verfasserin |4 aut | |
| 700 | 1 | |a Teirlinck, Anne C |e verfasserin |4 aut | |
| 700 | 1 | |a Fernandez, Liliana Vazquez |e verfasserin |4 aut | |
| 700 | 1 | |a Li, You |e verfasserin |4 aut | |
| 700 | 1 | |a Giaquinto, Carlo |e verfasserin |4 aut | |
| 700 | 1 | |a Fischer, Thea Kølsen |e verfasserin |4 aut | |
| 700 | 1 | |a Demont, Clarisse |e verfasserin |4 aut | |
| 700 | 1 | |a Heikkinen, Terho |e verfasserin |4 aut | |
| 700 | 1 | |a Speltra, Irene |e verfasserin |4 aut | |
| 700 | 1 | |a van Boven, Michiel |e verfasserin |4 aut | |
| 700 | 1 | |a Bøås, Håkon |e verfasserin |4 aut | |
| 700 | 1 | |a Campbell, Harry |e verfasserin |4 aut | |
| 700 | 0 | |a RESCEU Investigators |e verfasserin |4 aut | |
| 700 | 1 | |a Reeves, Rachel M |e investigator |4 oth | |
| 700 | 1 | |a Li, You |e investigator |4 oth | |
| 700 | 1 | |a Campbell, Harry |e investigator |4 oth | |
| 700 | 1 | |a Nair, Harish |e investigator |4 oth | |
| 700 | 1 | |a van Wijhe, Maarten |e investigator |4 oth | |
| 700 | 1 | |a Fischer, Thea Kølsen |e investigator |4 oth | |
| 700 | 1 | |a Simonsen, Lone |e investigator |4 oth | |
| 700 | 1 | |a Trebbien, Ramona |e investigator |4 oth | |
| 700 | 1 | |a Tong, Sabine |e investigator |4 oth | |
| 700 | 1 | |a Bangert, Mathieu |e investigator |4 oth | |
| 700 | 1 | |a Demont, Clarisse |e investigator |4 oth | |
| 700 | 1 | |a Lehtonen, Toni |e investigator |4 oth | |
| 700 | 1 | |a Heikkinen, Terho |e investigator |4 oth | |
| 700 | 1 | |a Teirlinck, Anne |e investigator |4 oth | |
| 700 | 1 | |a van Boven, Michiel |e investigator |4 oth | |
| 700 | 1 | |a van der Hoek, Wim |e investigator |4 oth | |
| 700 | 1 | |a van der Maas, Nicoline |e investigator |4 oth | |
| 700 | 1 | |a Meijer, Adam |e investigator |4 oth | |
| 700 | 1 | |a Fernandez, Liliana Vazquez |e investigator |4 oth | |
| 700 | 1 | |a Bøas, Håkon |e investigator |4 oth | |
| 700 | 1 | |a Bekkevold, Terese |e investigator |4 oth | |
| 700 | 1 | |a Flem, Elmira |e investigator |4 oth | |
| 700 | 1 | |a Stona, Luca |e investigator |4 oth | |
| 700 | 1 | |a Speltra, Irene |e investigator |4 oth | |
| 700 | 1 | |a Giaquinto, Carlo |e investigator |4 oth | |
| 700 | 1 | |a Cheret, Arnaud |e investigator |4 oth | |
| 700 | 1 | |a Leach, Amanda |e investigator |4 oth | |
| 700 | 1 | |a Stoszek, Sonia |e investigator |4 oth | |
| 700 | 1 | |a Beutels, Philippe |e investigator |4 oth | |
| 700 | 1 | |a Bont, Louis |e investigator |4 oth | |
| 700 | 1 | |a Pollard, Andrew |e investigator |4 oth | |
| 700 | 1 | |a Openshaw, Peter |e investigator |4 oth | |
| 700 | 1 | |a Abram, Michael |e investigator |4 oth | |
| 700 | 1 | |a Swanson, Kena |e investigator |4 oth | |
| 700 | 1 | |a Rosen, Brian |e investigator |4 oth | |
| 700 | 1 | |a Molero, Eva |e investigator |4 oth | |
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