Multicoding in neural information transfer suggested by mathematical analysis of the frequency-dependent synaptic plasticity in vivo
Two elements of neural information processing have primarily been proposed: firing rate and spike timing of neurons. In the case of synaptic plasticity, although spike-timing-dependent plasticity (STDP) depending on presynaptic and postsynaptic spike times had been considered the most common rule, recent studies have shown the inhibitory nature of the brain in vivo for precise spike timing, which is key to the STDP. Thus, the importance of the firing frequency in synaptic plasticity in vivo has been recognized again. However, little is understood about how the frequency-dependent synaptic plasticity (FDP) is regulated in vivo. Here, we focused on the presynaptic input pattern, the intracellular calcium decay time constants, and the background synaptic activity, which vary depending on neuron types and the anatomical and physiological environment in the brain. By analyzing a calcium-based model, we found that the synaptic weight differs depending on these factors characteristic in vivo, even if neurons receive the same input rate. This finding suggests the involvement of multifaceted factors other than input frequency in FDP and even neural coding in vivo.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Scientific reports - 10(2020), 1 vom: 18. Aug., Seite 13974 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hata, Katsuhiko [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 19.01.2021 Date Revised 18.08.2021 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41598-020-70876-4 |
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| Förderinstitution / Projekttitel: |
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NLM313858586 |
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| 245 | 1 | 0 | |a Multicoding in neural information transfer suggested by mathematical analysis of the frequency-dependent synaptic plasticity in vivo |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Two elements of neural information processing have primarily been proposed: firing rate and spike timing of neurons. In the case of synaptic plasticity, although spike-timing-dependent plasticity (STDP) depending on presynaptic and postsynaptic spike times had been considered the most common rule, recent studies have shown the inhibitory nature of the brain in vivo for precise spike timing, which is key to the STDP. Thus, the importance of the firing frequency in synaptic plasticity in vivo has been recognized again. However, little is understood about how the frequency-dependent synaptic plasticity (FDP) is regulated in vivo. Here, we focused on the presynaptic input pattern, the intracellular calcium decay time constants, and the background synaptic activity, which vary depending on neuron types and the anatomical and physiological environment in the brain. By analyzing a calcium-based model, we found that the synaptic weight differs depending on these factors characteristic in vivo, even if neurons receive the same input rate. This finding suggests the involvement of multifaceted factors other than input frequency in FDP and even neural coding in vivo | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Araki, Osamu |e verfasserin |4 aut | |
| 700 | 1 | |a Yokoi, Osamu |e verfasserin |4 aut | |
| 700 | 1 | |a Kusakabe, Tatsumi |e verfasserin |4 aut | |
| 700 | 1 | |a Yamamoto, Yoshio |e verfasserin |4 aut | |
| 700 | 1 | |a Ito, Susumu |e verfasserin |4 aut | |
| 700 | 1 | |a Nikuni, Tetsuro |e verfasserin |4 aut | |
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