Association between sex and mortality in adults with in-hospital and out-of-hospital cardiac arrest : A systematic review and meta-analysis
Copyright © 2020 Elsevier B.V. All rights reserved..
OBJECTIVES: Conflicting data exists regarding the association between sex and mortality in adults with in-hospital (IHCA) and out-of-hospital cardiac arrest (OHCA). We therefore conducted a meta-analysis to investigate the association between sex and mortality in adults with IHCA and OHCA.
METHODS: We systematically searched MEDLINE and Cochrane databases to identify studies reporting sex-specific mortality in adults following IHCA or OHCA from inception to April 2020. Data were pooled using random-effects models. The primary outcome of interest was in-hospital (or 30-day) all-cause mortality.
RESULTS: We included 21 observational studies with a total of 1,029,978 adult patients - 622,085 men and 407,893 women. Seven studies included patients only with IHCA and 14 studies included patients only with OHCA. Female sex was associated with significantly higher mortality following OHCA [odds ratio (OR) 1.56, 95% confidence interval (CI) 1.32-1.84, p < 0.001) and a trend toward higher mortality following IHCA (OR 1.10, 95%CI 1.00-1.20, p = 0.052).
CONCLUSIONS: In adults with cardiac arrest, female sex was associated with significantly higher mortality following OHCA and a trend toward higher mortality following IHCA.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:155 |
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| Enthalten in: |
Resuscitation - 155(2020) vom: 15. Okt., Seite 119-124 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Parikh, Puja B [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 21.06.2021 Date Revised 21.06.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.resuscitation.2020.07.031 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM313845786 |
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| 100 | 1 | |a Parikh, Puja B |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Association between sex and mortality in adults with in-hospital and out-of-hospital cardiac arrest |b A systematic review and meta-analysis |
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| 500 | |a Date Completed 21.06.2021 | ||
| 500 | |a Date Revised 21.06.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier B.V. All rights reserved. | ||
| 520 | |a OBJECTIVES: Conflicting data exists regarding the association between sex and mortality in adults with in-hospital (IHCA) and out-of-hospital cardiac arrest (OHCA). We therefore conducted a meta-analysis to investigate the association between sex and mortality in adults with IHCA and OHCA | ||
| 520 | |a METHODS: We systematically searched MEDLINE and Cochrane databases to identify studies reporting sex-specific mortality in adults following IHCA or OHCA from inception to April 2020. Data were pooled using random-effects models. The primary outcome of interest was in-hospital (or 30-day) all-cause mortality | ||
| 520 | |a RESULTS: We included 21 observational studies with a total of 1,029,978 adult patients - 622,085 men and 407,893 women. Seven studies included patients only with IHCA and 14 studies included patients only with OHCA. Female sex was associated with significantly higher mortality following OHCA [odds ratio (OR) 1.56, 95% confidence interval (CI) 1.32-1.84, p < 0.001) and a trend toward higher mortality following IHCA (OR 1.10, 95%CI 1.00-1.20, p = 0.052) | ||
| 520 | |a CONCLUSIONS: In adults with cardiac arrest, female sex was associated with significantly higher mortality following OHCA and a trend toward higher mortality following IHCA | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a Cardiac arrest | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Gender | |
| 650 | 4 | |a In-hospital cardiac arrest | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Men | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Out-of-hospital cardiac arrest | |
| 650 | 4 | |a Outcomes | |
| 650 | 4 | |a Sex | |
| 650 | 4 | |a Survival | |
| 650 | 4 | |a Women | |
| 700 | 1 | |a Hassan, Lukman |e verfasserin |4 aut | |
| 700 | 1 | |a Qadeer, Asem |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Jignesh K |e verfasserin |4 aut | |
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