IMRT versus 2D/3D conformal RT in oropharyngeal cancer : A review of the literature and meta-analysis
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd..
Based on literature, intensity-modulated radiation therapy (IMRT) provides less related toxicity compared with conventional 2D/3D-RT with no impact on oncological outcomes for oropharyngeal cancer. The aim of this systematic review and meta-analysis is to assess whether IMRT might provide similar clinical outcomes with reduced related toxicity in comparison with conventional 2D/3D RT in patients treated for clinically advanced oropharyngeal cancer (OPC). Inclusion criteria for paper selection included: squamous OPC patients, treatment performed by concomitant CRT or RT alone, four treatment performed for curative intent, and presence of clinical outcome of interest, namely, overall survival (OS) and disease-free survival (DFS) and full paper available in English. Acute and late toxicities were retrieved together with OS and DFS. Crude relative risk estimates of relapse and death comparing 2D/3D-RT versus IMRT were calculated from tabular data, extracting events at 2-3 years of follow-up. Eight studies were selected. Six of them were included in the meta-analysis considering summary relative risk. Considering both acute and late toxicities, the considered studies evidenced advantages for IMRT populations, with the 2D/3D-RT population showing higher frequencies than the IMRT one. No statistical difference between IMRT and 2D/3D-RT in terms of death (SRR = 0.93, 95% CI: 0.83-1.04 with no heterogeneity I2 = 0%) and relapse (SRR = 0.92, 95% CI: 0.83-1.03, with no heterogeneity I2 = 0%) was found. Results of our study suggest the improvement in the therapeutic index with IMRT with evidenced reduced toxicity without any worsening in clinical outcome when compared to 2D/3DCRT.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Oral diseases - 27(2021), 7 vom: 20. Okt., Seite 1644-1653 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Alterio, Daniela [VerfasserIn] |
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| Links: |
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| Themen: |
3D conformal radiotherapy |
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| Anmerkungen: |
Date Completed 01.10.2021 Date Revised 01.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/odi.13599 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM313844003 |
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| 520 | |a © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. | ||
| 520 | |a Based on literature, intensity-modulated radiation therapy (IMRT) provides less related toxicity compared with conventional 2D/3D-RT with no impact on oncological outcomes for oropharyngeal cancer. The aim of this systematic review and meta-analysis is to assess whether IMRT might provide similar clinical outcomes with reduced related toxicity in comparison with conventional 2D/3D RT in patients treated for clinically advanced oropharyngeal cancer (OPC). Inclusion criteria for paper selection included: squamous OPC patients, treatment performed by concomitant CRT or RT alone, four treatment performed for curative intent, and presence of clinical outcome of interest, namely, overall survival (OS) and disease-free survival (DFS) and full paper available in English. Acute and late toxicities were retrieved together with OS and DFS. Crude relative risk estimates of relapse and death comparing 2D/3D-RT versus IMRT were calculated from tabular data, extracting events at 2-3 years of follow-up. Eight studies were selected. Six of them were included in the meta-analysis considering summary relative risk. Considering both acute and late toxicities, the considered studies evidenced advantages for IMRT populations, with the 2D/3D-RT population showing higher frequencies than the IMRT one. No statistical difference between IMRT and 2D/3D-RT in terms of death (SRR = 0.93, 95% CI: 0.83-1.04 with no heterogeneity I2 = 0%) and relapse (SRR = 0.92, 95% CI: 0.83-1.03, with no heterogeneity I2 = 0%) was found. Results of our study suggest the improvement in the therapeutic index with IMRT with evidenced reduced toxicity without any worsening in clinical outcome when compared to 2D/3DCRT | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Review | |
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| 650 | 4 | |a 3D conformal radiotherapy | |
| 650 | 4 | |a IMRT | |
| 650 | 4 | |a head and neck cancer | |
| 650 | 4 | |a oropharyngeal cancer | |
| 650 | 4 | |a systematic review | |
| 700 | 1 | |a Gugliandolo, Simone Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Augugliaro, Matteo |e verfasserin |4 aut | |
| 700 | 1 | |a Marvaso, Giulia |e verfasserin |4 aut | |
| 700 | 1 | |a Gandini, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Bellerba, Federica |e verfasserin |4 aut | |
| 700 | 1 | |a Russell-Edu, Samuel William |e verfasserin |4 aut | |
| 700 | 1 | |a De Simone, Irene |e verfasserin |4 aut | |
| 700 | 1 | |a Cinquini, Michela |e verfasserin |4 aut | |
| 700 | 1 | |a Starzyńska, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Zaffaroni, Mattia |e verfasserin |4 aut | |
| 700 | 1 | |a Bacigalupo, Almalina |e verfasserin |4 aut | |
| 700 | 1 | |a Fanetti, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Durante, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Dicuonzo, Samantha |e verfasserin |4 aut | |
| 700 | 1 | |a Orecchia, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Jereczek-Fossa, Barbara Alicja |e verfasserin |4 aut | |
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