The PRIAMO study : age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson's disease
OBJECTIVES: To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson's disease at early stages.
METHODS: A total of 385 Parkinson's disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women).
RESULTS: As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only.
CONCLUSIONS: Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson's disease may impact disease phenotype.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:268 |
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| Enthalten in: |
Journal of neurology - 268(2021), 2 vom: 18. Feb., Seite 448-454 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Picillo, Marina [VerfasserIn] |
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| Links: |
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| Themen: |
Biomarkers |
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| Anmerkungen: |
Date Completed 18.06.2021 Date Revised 18.06.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00415-020-10156-3 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM31383668X |
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| 100 | 1 | |a Picillo, Marina |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The PRIAMO study |b age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson's disease |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 18.06.2021 | ||
| 500 | |a Date Revised 18.06.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson's disease at early stages | ||
| 520 | |a METHODS: A total of 385 Parkinson's disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women) | ||
| 520 | |a RESULTS: As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only | ||
| 520 | |a CONCLUSIONS: Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson's disease may impact disease phenotype | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Constipation | |
| 650 | 4 | |a Heterogeneity | |
| 650 | 4 | |a Parkinson | |
| 650 | 4 | |a Phenotype | |
| 650 | 4 | |a Prodromal | |
| 650 | 4 | |a Sex | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 700 | 1 | |a Palladino, Raffaele |e verfasserin |4 aut | |
| 700 | 1 | |a Erro, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Alfano, Rossella |e verfasserin |4 aut | |
| 700 | 1 | |a Colosimo, Carlo |e verfasserin |4 aut | |
| 700 | 1 | |a Marconi, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Antonini, Angelo |e verfasserin |4 aut | |
| 700 | 1 | |a Barone, Paolo |e verfasserin |4 aut | |
| 700 | 0 | |a PRIAMO study group |e verfasserin |4 aut | |
| 700 | 1 | |a Antonini, Angelo |e investigator |4 oth | |
| 700 | 1 | |a Colosimo, Carlo |e investigator |4 oth | |
| 700 | 1 | |a Marconi, Roberto |e investigator |4 oth | |
| 700 | 1 | |a Morgante, Letterio |e investigator |4 oth | |
| 700 | 1 | |a Benincasa, D |e investigator |4 oth | |
| 700 | 1 | |a Quatrale, R |e investigator |4 oth | |
| 700 | 1 | |a Biguzzi, S |e investigator |4 oth | |
| 700 | 1 | |a Braga, M |e investigator |4 oth | |
| 700 | 1 | |a Ceravolo, G |e investigator |4 oth | |
| 700 | 1 | |a Capecci, M |e investigator |4 oth | |
| 700 | 1 | |a Meco, G |e investigator |4 oth | |
| 700 | 1 | |a Caravona, N |e investigator |4 oth | |
| 700 | 1 | |a Scala, R |e investigator |4 oth | |
| 700 | 1 | |a De Falco, F A |e investigator |4 oth | |
| 700 | 1 | |a Pezzoli, G |e investigator |4 oth | |
| 700 | 1 | |a De Gaspari, D |e investigator |4 oth | |
| 700 | 1 | |a Bottacchi, E |e investigator |4 oth | |
| 700 | 1 | |a Di Giovanni, M |e investigator |4 oth | |
| 700 | 1 | |a Cannas, A |e investigator |4 oth | |
| 700 | 1 | |a Floris, G |e investigator |4 oth | |
| 700 | 1 | |a Gallerini, S |e investigator |4 oth | |
| 700 | 1 | |a Grasso, L |e investigator |4 oth | |
| 700 | 1 | |a Gaglio, R M |e investigator |4 oth | |
| 700 | 1 | |a Gurgone, G |e investigator |4 oth | |
| 700 | 1 | |a Volpe, G |e investigator |4 oth | |
| 700 | 1 | |a Zappulla, S |e investigator |4 oth | |
| 700 | 1 | |a Ceravolo, R |e investigator |4 oth | |
| 700 | 1 | |a Kiferle, L |e investigator |4 oth | |
| 700 | 1 | |a Ramat, S |e investigator |4 oth | |
| 700 | 1 | |a Meoni, S |e investigator |4 oth | |
| 700 | 1 | |a Pisani, A |e investigator |4 oth | |
| 700 | 1 | |a Moschella, V |e investigator |4 oth | |
| 700 | 1 | |a Morgante, F |e investigator |4 oth | |
| 700 | 1 | |a Savica, R |e investigator |4 oth | |
| 700 | 1 | |a Pepe, F |e investigator |4 oth | |
| 700 | 1 | |a Ciccarelli, G |e investigator |4 oth | |
| 700 | 1 | |a Petretta, V |e investigator |4 oth | |
| 700 | 1 | |a Giglia, R M |e investigator |4 oth | |
| 700 | 1 | |a Randisi, M G |e investigator |4 oth | |
| 700 | 1 | |a Iemolo, F |e investigator |4 oth | |
| 700 | 1 | |a Avarello, T P |e investigator |4 oth | |
| 700 | 1 | |a Romeno, M |e investigator |4 oth | |
| 700 | 1 | |a Santangelo, G |e investigator |4 oth | |
| 700 | 1 | |a Stocchi, F |e investigator |4 oth | |
| 700 | 1 | |a Sciortino, G |e investigator |4 oth | |
| 700 | 1 | |a Sorbello, V |e investigator |4 oth | |
| 700 | 1 | |a Nicoletti, A |e investigator |4 oth | |
| 700 | 1 | |a Tiple, D |e investigator |4 oth | |
| 700 | 1 | |a Fabbrini, G |e investigator |4 oth | |
| 700 | 1 | |a Bentivoglio, A |e investigator |4 oth | |
| 700 | 1 | |a Pontieri, F E |e investigator |4 oth | |
| 700 | 1 | |a Guidubaldi, A |e investigator |4 oth | |
| 700 | 1 | |a Muoio, R |e investigator |4 oth | |
| 700 | 1 | |a Toni, V |e investigator |4 oth | |
| 700 | 1 | |a Del Dotto, P |e investigator |4 oth | |
| 700 | 1 | |a Logi, C |e investigator |4 oth | |
| 700 | 1 | |a Ciacci, G |e investigator |4 oth | |
| 700 | 1 | |a Ulivelli, M |e investigator |4 oth | |
| 700 | 1 | |a Perini, M |e investigator |4 oth | |
| 700 | 1 | |a Lanfranchi, S |e investigator |4 oth | |
| 700 | 1 | |a Griffini, S |e investigator |4 oth | |
| 700 | 1 | |a Troianiello, B |e investigator |4 oth | |
| 700 | 1 | |a Baratti, M |e investigator |4 oth | |
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| 700 | 1 | |a Consoli, D |e investigator |4 oth | |
| 700 | 1 | |a Iellamo, M |e investigator |4 oth | |
| 700 | 1 | |a Cuomo, T |e investigator |4 oth | |
| 700 | 1 | |a Scaglioni, A |e investigator |4 oth | |
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| 700 | 1 | |a Manfredi, M |e investigator |4 oth | |
| 700 | 1 | |a Abbruzzese, G |e investigator |4 oth | |
| 700 | 1 | |a Di Brigida, G |e investigator |4 oth | |
| 700 | 1 | |a Cocco, G A |e investigator |4 oth | |
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| 700 | 1 | |a Pesare, M |e investigator |4 oth | |
| 700 | 1 | |a Nordera, G |e investigator |4 oth | |
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