Clinical outcomes of different treatments and risk factors in patients with otogenic brain abscess, a real-world evidence-based retrospective study
BACKGROUND: Otogenic Brain Abscess (OBA) is a life-threatening complication secondary to otitis media, but its appropriate management remains controversial.
OBJECTIVES: To understand the demographic characteristics, management, and variables that affect the outcomes of patients with OBA based on our experiences over 11 years.
MATERIAL AND METHODS: Clinical data were collected for 41 patients. Prognostic factors associated with mortality were assessed, and clinical outcomes compared among groups receiving different treatments.
RESULTS: Among the 41 patients, 19.6% did not undergo surgery, 39.0% were treated with two-stage surgery (otological surgery and neurosurgery) and 41.4% were treated with single-stage surgery (otological surgery or neurosurgery). Overall mortality rate was 32.5%, and mortality was significantly higher in patients with invasion of the petrous apex (odds ratio [OR]: 7.81, 95% confidence interval [95% CI]: 1.26-48.36), and lower in those with appropriate surgical management (single otological surgery, OR: 0.07, 95% CI: 0-0.97; single neurosurgery, OR: 0.13, 95% CI: 0.02-1.0; two-stage surgery, OR: 0.08, 95% CI: 0.01-0.64) or a higher Glasgow Coma Scale (GCS) score at admission (OR: 0.64, 95% CI: 0.44-0.93).
CONCLUSIONS AND SIGNIFICANCE: Data on invasiveness and pre-surgery GCS greatly aid in predicting the prognosis of OBA patients. Early evaluation will facilitate decision-making by physicians treating OBA patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:140 |
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| Enthalten in: |
Acta oto-laryngologica - 140(2020), 11 vom: 12. Nov., Seite 919-924 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Song, Yao [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Bacterial Agents |
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| Anmerkungen: |
Date Completed 06.09.2021 Date Revised 06.09.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/00016489.2020.1800088 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM313791465 |
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| 245 | 1 | 0 | |a Clinical outcomes of different treatments and risk factors in patients with otogenic brain abscess, a real-world evidence-based retrospective study |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Otogenic Brain Abscess (OBA) is a life-threatening complication secondary to otitis media, but its appropriate management remains controversial | ||
| 520 | |a OBJECTIVES: To understand the demographic characteristics, management, and variables that affect the outcomes of patients with OBA based on our experiences over 11 years | ||
| 520 | |a MATERIAL AND METHODS: Clinical data were collected for 41 patients. Prognostic factors associated with mortality were assessed, and clinical outcomes compared among groups receiving different treatments | ||
| 520 | |a RESULTS: Among the 41 patients, 19.6% did not undergo surgery, 39.0% were treated with two-stage surgery (otological surgery and neurosurgery) and 41.4% were treated with single-stage surgery (otological surgery or neurosurgery). Overall mortality rate was 32.5%, and mortality was significantly higher in patients with invasion of the petrous apex (odds ratio [OR]: 7.81, 95% confidence interval [95% CI]: 1.26-48.36), and lower in those with appropriate surgical management (single otological surgery, OR: 0.07, 95% CI: 0-0.97; single neurosurgery, OR: 0.13, 95% CI: 0.02-1.0; two-stage surgery, OR: 0.08, 95% CI: 0.01-0.64) or a higher Glasgow Coma Scale (GCS) score at admission (OR: 0.64, 95% CI: 0.44-0.93) | ||
| 520 | |a CONCLUSIONS AND SIGNIFICANCE: Data on invasiveness and pre-surgery GCS greatly aid in predicting the prognosis of OBA patients. Early evaluation will facilitate decision-making by physicians treating OBA patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Otogenic brain abscess | |
| 650 | 4 | |a clinical outcome | |
| 650 | 4 | |a different treatment | |
| 650 | 4 | |a risk factor | |
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| 700 | 1 | |a Cheng, Danni |e verfasserin |4 aut | |
| 700 | 1 | |a Qiu, Ke |e verfasserin |4 aut | |
| 700 | 1 | |a Yan, Xiaohong |e verfasserin |4 aut | |
| 700 | 1 | |a Ren, Jianjun |e verfasserin |4 aut | |
| 700 | 1 | |a Qiu, Jianqing |e verfasserin |4 aut | |
| 700 | 1 | |a Deng, Di |e verfasserin |4 aut | |
| 700 | 1 | |a Rao, Yufang |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Yongbo |e verfasserin |4 aut | |
| 700 | 1 | |a Pang, Wendu |e verfasserin |4 aut | |
| 700 | 1 | |a Dong, Yijun |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Qiurui |e verfasserin |4 aut | |
| 700 | 1 | |a Ren, Yanming |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Yu |e verfasserin |4 aut | |
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