Deceased donors as nondirected donors in kidney paired donation
© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons..
As proof of concept, we simulate a revised kidney allocation system that includes deceased donor (DD) kidneys as chain-initiating kidneys (DD-CIK) in a kidney paired donation pool (KPDP), and estimate potential increases in number of transplants. We consider chains of length 2 in which the DD-CIK gives to a candidate in the KPDP, and that candidate's incompatible donor donates to theDD waitlist. In simulations, we vary initial pool size, arrival rates of candidate/donor pairs and (living) nondirected donors (NDDs), and delay time from entry to the KPDP until a candidate is eligible to receive a DD-CIK. Using data on candidate/donor pairs and NDDs from the Alliance for Paired Kidney Donation, and the actual DDs from the Scientific Registry of Transplant Recipients (SRTR) data, simulations extend over 2 years. With an initial pool of 400, respective candidate and NDD arrival rates of 2 per day and 3 per month, and delay times for access to DD-CIK of 6 months or less, including DD-CIKs increases the number of transplants by at least 447 over 2 years, and greatly reduces waiting times of KPDP candidates. Potential effects on waitlist candidates are discussed as are policy and ethical issues.
| Errataetall: |
CommentIn: Am J Transplant. 2021 Jan;21(1):5-6. - PMID 33080097 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 21(2021), 1 vom: 08. Jan., Seite 103-113 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Wen [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 18.06.2021 Date Revised 24.01.2023 published: Print-Electronic CommentIn: Am J Transplant. 2021 Jan;21(1):5-6. - PMID 33080097 Citation Status MEDLINE |
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| doi: |
10.1111/ajt.16268 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM313784574 |
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| 500 | |a CommentIn: Am J Transplant. 2021 Jan;21(1):5-6. - PMID 33080097 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 The American Society of Transplantation and the American Society of Transplant Surgeons. | ||
| 520 | |a As proof of concept, we simulate a revised kidney allocation system that includes deceased donor (DD) kidneys as chain-initiating kidneys (DD-CIK) in a kidney paired donation pool (KPDP), and estimate potential increases in number of transplants. We consider chains of length 2 in which the DD-CIK gives to a candidate in the KPDP, and that candidate's incompatible donor donates to theDD waitlist. In simulations, we vary initial pool size, arrival rates of candidate/donor pairs and (living) nondirected donors (NDDs), and delay time from entry to the KPDP until a candidate is eligible to receive a DD-CIK. Using data on candidate/donor pairs and NDDs from the Alliance for Paired Kidney Donation, and the actual DDs from the Scientific Registry of Transplant Recipients (SRTR) data, simulations extend over 2 years. With an initial pool of 400, respective candidate and NDD arrival rates of 2 per day and 3 per month, and delay times for access to DD-CIK of 6 months or less, including DD-CIKs increases the number of transplants by at least 447 over 2 years, and greatly reduces waiting times of KPDP candidates. Potential effects on waitlist candidates are discussed as are policy and ethical issues | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 650 | 4 | |a donors and donation: deceased | |
| 650 | 4 | |a donors and donation: paired exchange | |
| 650 | 4 | |a health services and outcomes research | |
| 650 | 4 | |a kidney transplantation/ nephrology | |
| 650 | 4 | |a simulation | |
| 650 | 4 | |a statistics | |
| 700 | 1 | |a Rees, Michael A |e verfasserin |4 aut | |
| 700 | 1 | |a Leichtman, Alan B |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Peter X-K |e verfasserin |4 aut | |
| 700 | 1 | |a Bray, Mathieu |e verfasserin |4 aut | |
| 700 | 1 | |a Ashby, Valarie B |e verfasserin |4 aut | |
| 700 | 1 | |a Shearon, Tempie |e verfasserin |4 aut | |
| 700 | 1 | |a Whiteman, Andrew |e verfasserin |4 aut | |
| 700 | 1 | |a Kalbfleisch, John D |e verfasserin |4 aut | |
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