Hyperconnectivity in Dementia Is Early and Focal and Wanes with Progression
© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissionoup.com..
We investigated in a longitudinal multicenter cohort study functional cortical connectivity changes along the course of frontotemporal dementia (FTD) and Alzheimer's disease (AD) from the prodromal stage of the diseases. Electroencephalography (EEG) was recorded in 18 FTD and 18 AD patients at the prodromal stage of dementia, at dementia onset, and 3 years after dementia onset. Twenty healthy controls (HC) underwent EEG recordings at the same time interval as the patients. Mutual information (MI) analysis measured the strength of functional network connectivity. FTD and AD patients showed greater MI at the prodromal stage of dementia (FTD vs. HC P = 2 × 10-8; AD vs. HC P = 4 × 10-3). Local connectivity was higher in left and right frontal areas of FTD (P = 7 × 10-5 and 0.03) and in left and right posterior areas in AD (P = 3 × 10-5 and 5 × 10-5) versus HC. We showed cortical hyperconnectivity at the prodromal stage of dementia in areas involved in the specific pathological process of FTD (frontal regions) and AD (posterior regions). Hyperconnectivity disappeared during follow-up, thus suggesting that it is an early electrophysiological feature of dementia, potentially useful to identify prodromal FTD and AD.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
|---|---|
| Enthalten in: |
Cerebral cortex (New York, N.Y. : 1991) - 31(2021), 1 vom: 01. Jan., Seite 97-105 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Bonanni, Laura [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Alzheimer’s disease |
|---|
| Anmerkungen: |
Date Completed 30.12.2021 Date Revised 30.12.2021 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1093/cercor/bhaa209 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM313718423 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM313718423 | ||
| 003 | DE-627 | ||
| 005 | 20231225151155.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/cercor/bhaa209 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1045.xml |
| 035 | |a (DE-627)NLM313718423 | ||
| 035 | |a (NLM)32797208 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Bonanni, Laura |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Hyperconnectivity in Dementia Is Early and Focal and Wanes with Progression |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 30.12.2021 | ||
| 500 | |a Date Revised 30.12.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissionoup.com. | ||
| 520 | |a We investigated in a longitudinal multicenter cohort study functional cortical connectivity changes along the course of frontotemporal dementia (FTD) and Alzheimer's disease (AD) from the prodromal stage of the diseases. Electroencephalography (EEG) was recorded in 18 FTD and 18 AD patients at the prodromal stage of dementia, at dementia onset, and 3 years after dementia onset. Twenty healthy controls (HC) underwent EEG recordings at the same time interval as the patients. Mutual information (MI) analysis measured the strength of functional network connectivity. FTD and AD patients showed greater MI at the prodromal stage of dementia (FTD vs. HC P = 2 × 10-8; AD vs. HC P = 4 × 10-3). Local connectivity was higher in left and right frontal areas of FTD (P = 7 × 10-5 and 0.03) and in left and right posterior areas in AD (P = 3 × 10-5 and 5 × 10-5) versus HC. We showed cortical hyperconnectivity at the prodromal stage of dementia in areas involved in the specific pathological process of FTD (frontal regions) and AD (posterior regions). Hyperconnectivity disappeared during follow-up, thus suggesting that it is an early electrophysiological feature of dementia, potentially useful to identify prodromal FTD and AD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Alzheimer’s disease | |
| 650 | 4 | |a EEG | |
| 650 | 4 | |a frontotemporal dementia | |
| 650 | 4 | |a hyperconnectivity | |
| 700 | 1 | |a Moretti, Davide |e verfasserin |4 aut | |
| 700 | 1 | |a Benussi, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Ferri, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Russo, Mirella |e verfasserin |4 aut | |
| 700 | 1 | |a Carrarini, Claudia |e verfasserin |4 aut | |
| 700 | 1 | |a Barbone, Filomena |e verfasserin |4 aut | |
| 700 | 1 | |a Arnaldi, Dario |e verfasserin |4 aut | |
| 700 | 1 | |a Falasca, Nicola Walter |e verfasserin |4 aut | |
| 700 | 1 | |a Koch, Giacomo |e verfasserin |4 aut | |
| 700 | 1 | |a Cagnin, Annachiara |e verfasserin |4 aut | |
| 700 | 1 | |a Nobili, Flavio |e verfasserin |4 aut | |
| 700 | 1 | |a Babiloni, Claudio |e verfasserin |4 aut | |
| 700 | 1 | |a Borroni, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Padovani, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Onofrj, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Franciotti, Raffaella |e verfasserin |4 aut | |
| 700 | 0 | |a FTD Italian study group-SINDEM |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cerebral cortex (New York, N.Y. : 1991) |d 1997 |g 31(2021), 1 vom: 01. Jan., Seite 97-105 |w (DE-627)NLM012627887 |x 1460-2199 |7 nnns |
| 773 | 1 | 8 | |g volume:31 |g year:2021 |g number:1 |g day:01 |g month:01 |g pages:97-105 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/cercor/bhaa209 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 31 |j 2021 |e 1 |b 01 |c 01 |h 97-105 | ||