Might SARS-CoV-2 Have Arisen via Serial Passage through an Animal Host or Cell Culture? : A potential explanation for much of the novel coronavirus' distinctive genome
© 2020 Wiley Periodicals LLC..
Despite claims from prominent scientists that SARS-CoV-2 indubitably emerged naturally, the etiology of this novel coronavirus remains a pressing and open question: Without knowing the true nature of a disease, it is impossible for clinicians to appropriately shape their care, for policy-makers to correctly gauge the nature and extent of the threat, and for the public to appropriately modify their behavior. Unless the intermediate host necessary for completing a natural zoonotic jump is identified, the dual-use gain-of-function research practice of viral serial passage should be considered a viable route by which the novel coronavirus arose. The practice of serial passage mimics a natural zoonotic jump, and offers explanations for SARS-CoV-2's distinctive spike-protein region and its unexpectedly high affinity for angiotensin converting enzyme (ACE2), as well as the notable polybasic furin cleavage site within it. Additional molecular clues raise further questions, all of which warrant full investigation into the novel coronavirus's origins and a re-examination of the risks and rewards of dual-use gain-of-function research.
| Errataetall: |
CommentIn: Bioessays. 2021 Apr;43(4):e2100017. - PMID 33576073 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:42 |
|---|---|
| Enthalten in: |
BioEssays : news and reviews in molecular, cellular and developmental biology - 42(2020), 10 vom: 18. Okt., Seite e2000091 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Sirotkin, Karl [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 05.10.2020 Date Revised 16.07.2022 published: Print-Electronic CommentIn: Bioessays. 2021 Apr;43(4):e2100017. - PMID 33576073 Citation Status MEDLINE |
|---|
| doi: |
10.1002/bies.202000091 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM313607559 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM313607559 | ||
| 003 | DE-627 | ||
| 005 | 20231225150935.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/bies.202000091 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1045.xml |
| 035 | |a (DE-627)NLM313607559 | ||
| 035 | |a (NLM)32786014 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Sirotkin, Karl |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Might SARS-CoV-2 Have Arisen via Serial Passage through an Animal Host or Cell Culture? |b A potential explanation for much of the novel coronavirus' distinctive genome |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 05.10.2020 | ||
| 500 | |a Date Revised 16.07.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Bioessays. 2021 Apr;43(4):e2100017. - PMID 33576073 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 Wiley Periodicals LLC. | ||
| 520 | |a Despite claims from prominent scientists that SARS-CoV-2 indubitably emerged naturally, the etiology of this novel coronavirus remains a pressing and open question: Without knowing the true nature of a disease, it is impossible for clinicians to appropriately shape their care, for policy-makers to correctly gauge the nature and extent of the threat, and for the public to appropriately modify their behavior. Unless the intermediate host necessary for completing a natural zoonotic jump is identified, the dual-use gain-of-function research practice of viral serial passage should be considered a viable route by which the novel coronavirus arose. The practice of serial passage mimics a natural zoonotic jump, and offers explanations for SARS-CoV-2's distinctive spike-protein region and its unexpectedly high affinity for angiotensin converting enzyme (ACE2), as well as the notable polybasic furin cleavage site within it. Additional molecular clues raise further questions, all of which warrant full investigation into the novel coronavirus's origins and a re-examination of the risks and rewards of dual-use gain-of-function research | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a coronavirus | |
| 650 | 4 | |a gain-of-function | |
| 650 | 4 | |a intermediate host | |
| 650 | 4 | |a pandemic | |
| 650 | 4 | |a serial passage | |
| 650 | 4 | |a virology | |
| 650 | 7 | |a Spike Glycoprotein, Coronavirus |2 NLM | |
| 650 | 7 | |a spike glycoprotein, SARS-CoV |2 NLM | |
| 650 | 7 | |a Peptidyl-Dipeptidase A |2 NLM | |
| 650 | 7 | |a EC 3.4.15.1 |2 NLM | |
| 650 | 7 | |a ACE2 protein, human |2 NLM | |
| 650 | 7 | |a EC 3.4.17.23 |2 NLM | |
| 650 | 7 | |a Angiotensin-Converting Enzyme 2 |2 NLM | |
| 650 | 7 | |a EC 3.4.17.23 |2 NLM | |
| 700 | 1 | |a Sirotkin, Dan |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t BioEssays : news and reviews in molecular, cellular and developmental biology |d 1993 |g 42(2020), 10 vom: 18. Okt., Seite e2000091 |w (DE-627)NLM012660450 |x 1521-1878 |7 nnns |
| 773 | 1 | 8 | |g volume:42 |g year:2020 |g number:10 |g day:18 |g month:10 |g pages:e2000091 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/bies.202000091 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 42 |j 2020 |e 10 |b 18 |c 10 |h e2000091 | ||