Yellow Subretinal Lesions following Initiation of Antituberculosis Therapy in A Tubercular Choroidal Granuloma : A Sign of Paradoxical Worsening?
PURPOSE: To describe the presentation and management of atypical subretinal lesions following initiation of antitubercular therapy for a tubercular choroidal granuloma.
CASE REPORT: An 18-year-old female was diagnosed with choroidal granuloma and shallow exudative retinal detachment in the left eye. Biopsy from a cervical lymph node was positive for tuberculosis. She was treated with antitubercular therapy (ATT) and oral steroids. After one week of therapy exudative detachment increased markedly and discrete yellowish-white subretinal lesions appeared first in the inferior periphery, then temporally and later involved the macula leading to a drop in visual acuity. A diagnosis of paradoxical worsening was considered and she was managed with a higher dose of oral corticosteroids, intravitreal methotrexate and intravitreal ranibizumab. The granuloma healed and the subretinal lesions as well as exudative detachment gradually resolved with improvement in visual acuity.
CONCLUSION: Subretinal yellow-white lesions may develop as a paradoxical response to ATT.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
|---|---|
| Enthalten in: |
Ocular immunology and inflammation - 30(2022), 1 vom: 02. Jan., Seite 29-33 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Arora, Atul [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
ATT |
|---|
| Anmerkungen: |
Date Completed 16.03.2022 Date Revised 22.04.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1080/09273948.2020.1780272 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM313584737 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM313584737 | ||
| 003 | DE-627 | ||
| 005 | 20231225150906.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/09273948.2020.1780272 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1045.xml |
| 035 | |a (DE-627)NLM313584737 | ||
| 035 | |a (NLM)32783681 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Arora, Atul |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Yellow Subretinal Lesions following Initiation of Antituberculosis Therapy in A Tubercular Choroidal Granuloma |b A Sign of Paradoxical Worsening? |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 16.03.2022 | ||
| 500 | |a Date Revised 22.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: To describe the presentation and management of atypical subretinal lesions following initiation of antitubercular therapy for a tubercular choroidal granuloma | ||
| 520 | |a CASE REPORT: An 18-year-old female was diagnosed with choroidal granuloma and shallow exudative retinal detachment in the left eye. Biopsy from a cervical lymph node was positive for tuberculosis. She was treated with antitubercular therapy (ATT) and oral steroids. After one week of therapy exudative detachment increased markedly and discrete yellowish-white subretinal lesions appeared first in the inferior periphery, then temporally and later involved the macula leading to a drop in visual acuity. A diagnosis of paradoxical worsening was considered and she was managed with a higher dose of oral corticosteroids, intravitreal methotrexate and intravitreal ranibizumab. The granuloma healed and the subretinal lesions as well as exudative detachment gradually resolved with improvement in visual acuity | ||
| 520 | |a CONCLUSION: Subretinal yellow-white lesions may develop as a paradoxical response to ATT | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ATT | |
| 650 | 4 | |a Ocular tuberculosis | |
| 650 | 4 | |a SRHM | |
| 650 | 4 | |a anti tubercular therapy | |
| 650 | 4 | |a choroidal granuloma | |
| 650 | 4 | |a paradoxical worsening | |
| 650 | 4 | |a subretinal deposits | |
| 650 | 7 | |a Antitubercular Agents |2 NLM | |
| 650 | 7 | |a Ranibizumab |2 NLM | |
| 650 | 7 | |a ZL1R02VT79 |2 NLM | |
| 700 | 1 | |a Katoch, Deeksha |e verfasserin |4 aut | |
| 700 | 1 | |a Jain, Sahil |e verfasserin |4 aut | |
| 700 | 1 | |a Singh, Simar Rajan |e verfasserin |4 aut | |
| 700 | 1 | |a Gupta, Vishali |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Ocular immunology and inflammation |d 1993 |g 30(2022), 1 vom: 02. Jan., Seite 29-33 |w (DE-627)NLM091014069 |x 1744-5078 |7 nnns |
| 773 | 1 | 8 | |g volume:30 |g year:2022 |g number:1 |g day:02 |g month:01 |g pages:29-33 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/09273948.2020.1780272 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 30 |j 2022 |e 1 |b 02 |c 01 |h 29-33 | ||