The prevalence rate of anti-SARS-CoV-2-IgG is 1.2% - Screening in asymptomatic outpatients in Germany (Northrhine-Westfalia)
Patients with newly diagnosed COVID-19 (coronavirus disease 2019) develop antibodies against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). To date, few data have been obtained of the prevalence of SARS-CoV-2-antibodies in general population and in asymptomatic outpatients in Germany.From March 26 to June 4 2020, 415 asymptomatic outpatients were tested prospectively in Northrhine-Westfalia (Germany), to detect SARS-CoV-2-IgG-antibodies. In case of a positive result, anti-SARS-CoV-2-IgA was determined additionally.5 of 415 asymptomatic outpatients had positive SARS-CoV-2-IgG-antibodies with a calculated prevalence of 1.2%. Reference range of anti-SARS-CoV-2-IgA and IgG was defined as ratio for negative < 0.8, borderline 0.8-1.1 and > 1.1 positive. The mean concentration of SARS-CoV-2-IgG-antibodies of the positive 5 outpatients was lower than in symptomatic patients with COVID-19 (n = 12) and positive PCR of SARS-CoV-2 (3.04 ± 2.58 versus 8.05 ± 6.70; p = 0.002). 4 of 5 patients had elevated SARS-CoV-2-IgA-antibodies (1.61 ± 0.82). In 408 screening-outpatients with negative anti-SARS-CoV-2-ELISA-IgG (< 0.8), the mean ratio was 0.25 ± 0.13. Two patients were in the borderline range (0.83 and 0.86).The prevalence of 1.2% of SARS-CoV-2-IgG-antibodies and consequently the rate of infection in asymptomatic outpatients in Northrhine-Westfalia (Germany) is low. The impact of virus neutralisation by antibodies and consequently immunization is the challenge of further investigations.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2020 |
---|---|
Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:162 |
---|---|
Enthalten in: |
MMW Fortschritte der Medizin - 162(2020), 14 vom: 11. Aug., Seite 44-46 |
Sprache: |
Deutsch |
---|
Weiterer Titel: |
Die Prävalenz von SARS-CoV-2-IgG-AK liegt bei 1,2% : Screening bei asymptomatischen ambulanten Patienten |
---|
Beteiligte Personen: |
Herrmann, Burkhard L [VerfasserIn] |
---|
Links: |
---|
Themen: |
Antibodies, Viral |
---|
Anmerkungen: |
Date Completed 19.08.2020 Date Revised 18.12.2020 published: Print Citation Status MEDLINE |
---|
doi: |
10.1007/s15006-020-0750-y |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM313552061 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM313552061 | ||
003 | DE-627 | ||
005 | 20231225150824.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2020 xx |||||o 00| ||ger c | ||
024 | 7 | |a 10.1007/s15006-020-0750-y |2 doi | |
028 | 5 | 2 | |a pubmed24n1045.xml |
035 | |a (DE-627)NLM313552061 | ||
035 | |a (NLM)32780376 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a ger | ||
100 | 1 | |a Herrmann, Burkhard L |e verfasserin |4 aut | |
245 | 1 | 4 | |a The prevalence rate of anti-SARS-CoV-2-IgG is 1.2% - Screening in asymptomatic outpatients in Germany (Northrhine-Westfalia) |
246 | 3 | 3 | |a Die Prävalenz von SARS-CoV-2-IgG-AK liegt bei 1,2% : Screening bei asymptomatischen ambulanten Patienten |
264 | 1 | |c 2020 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 19.08.2020 | ||
500 | |a Date Revised 18.12.2020 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Patients with newly diagnosed COVID-19 (coronavirus disease 2019) develop antibodies against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). To date, few data have been obtained of the prevalence of SARS-CoV-2-antibodies in general population and in asymptomatic outpatients in Germany.From March 26 to June 4 2020, 415 asymptomatic outpatients were tested prospectively in Northrhine-Westfalia (Germany), to detect SARS-CoV-2-IgG-antibodies. In case of a positive result, anti-SARS-CoV-2-IgA was determined additionally.5 of 415 asymptomatic outpatients had positive SARS-CoV-2-IgG-antibodies with a calculated prevalence of 1.2%. Reference range of anti-SARS-CoV-2-IgA and IgG was defined as ratio for negative < 0.8, borderline 0.8-1.1 and > 1.1 positive. The mean concentration of SARS-CoV-2-IgG-antibodies of the positive 5 outpatients was lower than in symptomatic patients with COVID-19 (n = 12) and positive PCR of SARS-CoV-2 (3.04 ± 2.58 versus 8.05 ± 6.70; p = 0.002). 4 of 5 patients had elevated SARS-CoV-2-IgA-antibodies (1.61 ± 0.82). In 408 screening-outpatients with negative anti-SARS-CoV-2-ELISA-IgG (< 0.8), the mean ratio was 0.25 ± 0.13. Two patients were in the borderline range (0.83 and 0.86).The prevalence of 1.2% of SARS-CoV-2-IgG-antibodies and consequently the rate of infection in asymptomatic outpatients in Northrhine-Westfalia (Germany) is low. The impact of virus neutralisation by antibodies and consequently immunization is the challenge of further investigations | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a IgG-antibodies | |
650 | 4 | |a SARS-CoV-2 | |
650 | 4 | |a prevalence | |
650 | 4 | |a screening | |
650 | 7 | |a Antibodies, Viral |2 NLM | |
650 | 7 | |a Immunoglobulin A |2 NLM | |
650 | 7 | |a Immunoglobulin G |2 NLM | |
773 | 0 | 8 | |i Enthalten in |t MMW Fortschritte der Medizin |d 1999 |g 162(2020), 14 vom: 11. Aug., Seite 44-46 |w (DE-627)NLM103996869 |x 1613-3560 |7 nnns |
773 | 1 | 8 | |g volume:162 |g year:2020 |g number:14 |g day:11 |g month:08 |g pages:44-46 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/s15006-020-0750-y |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 162 |j 2020 |e 14 |b 11 |c 08 |h 44-46 |