Vitamin D supplementation in pregnancy and early infancy in relation to gut microbiota composition and C. difficile colonization : implications for viral respiratory infections
In Canada and the US, the infant diet is supplemented with vitamin D via supplement drops or formula. Pregnant and nursing mothers often take vitamin D supplements. Since little is known about the impact of this supplementation on infant gut microbiota, we undertook a study to determine the association between maternal and infant vitamin D supplementation, infant gut microbiota composition and Clostridioides difficile colonization in 1,157 mother-infant pairs of the CHILD (Canadian Healthy Infant Longitudinal Development) Cohort Study over 2009-2012. Logistic and MaAsLin regression were employed to assess associations between vitamin D supplementation, and C. difficile colonization, or other gut microbiota, respectively. Sixty-five percent of infants received a vitamin D supplement. Among all infants, infant vitamin D supplementation was associated with a lower abundance of genus Megamonas (q = 0.01) in gut microbiota. Among those exclusively breastfed, maternal prenatal supplementation was associated with lower abundance of Bilophila (q = 0.01) and of Lachnospiraceae (q = 0.02) but higher abundance of Haemophilus (q = 0.02). There were no differences in microbiota composition with vitamin D supplementation among partially and not breastfed infants. Neither infant nor maternal vitamin D supplementation were associated with C. difficile colonization, after adjusting for breastfeeding status and other factors. However, maternal consumption of vitamin-D fortified milk reduced the likelihood of C. difficile colonization in infants (adjustedOR: 0.40, 95% CI: 0.19-0.82). The impact of this compositional difference on later childhood health, especially defense against viral respiratory infection, may go beyond the expected effects of vitamin D supplements and remains to be ascertained.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
|---|---|
| Enthalten in: |
Gut microbes - 12(2020), 1 vom: 09. Nov., Seite 1799734 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Drall, Kelsea M [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
1406-16-2 |
|---|
| Anmerkungen: |
Date Completed 30.09.2021 Date Revised 30.09.2021 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1080/19490976.2020.1799734 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM313548226 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM313548226 | ||
| 003 | DE-627 | ||
| 005 | 20231225150819.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/19490976.2020.1799734 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1045.xml |
| 035 | |a (DE-627)NLM313548226 | ||
| 035 | |a (NLM)32779963 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Drall, Kelsea M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Vitamin D supplementation in pregnancy and early infancy in relation to gut microbiota composition and C. difficile colonization |b implications for viral respiratory infections |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 30.09.2021 | ||
| 500 | |a Date Revised 30.09.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a In Canada and the US, the infant diet is supplemented with vitamin D via supplement drops or formula. Pregnant and nursing mothers often take vitamin D supplements. Since little is known about the impact of this supplementation on infant gut microbiota, we undertook a study to determine the association between maternal and infant vitamin D supplementation, infant gut microbiota composition and Clostridioides difficile colonization in 1,157 mother-infant pairs of the CHILD (Canadian Healthy Infant Longitudinal Development) Cohort Study over 2009-2012. Logistic and MaAsLin regression were employed to assess associations between vitamin D supplementation, and C. difficile colonization, or other gut microbiota, respectively. Sixty-five percent of infants received a vitamin D supplement. Among all infants, infant vitamin D supplementation was associated with a lower abundance of genus Megamonas (q = 0.01) in gut microbiota. Among those exclusively breastfed, maternal prenatal supplementation was associated with lower abundance of Bilophila (q = 0.01) and of Lachnospiraceae (q = 0.02) but higher abundance of Haemophilus (q = 0.02). There were no differences in microbiota composition with vitamin D supplementation among partially and not breastfed infants. Neither infant nor maternal vitamin D supplementation were associated with C. difficile colonization, after adjusting for breastfeeding status and other factors. However, maternal consumption of vitamin-D fortified milk reduced the likelihood of C. difficile colonization in infants (adjustedOR: 0.40, 95% CI: 0.19-0.82). The impact of this compositional difference on later childhood health, especially defense against viral respiratory infection, may go beyond the expected effects of vitamin D supplements and remains to be ascertained | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Bilophila | |
| 650 | 4 | |a C. difficile | |
| 650 | 4 | |a Megamonas | |
| 650 | 4 | |a Vitamin D | |
| 650 | 4 | |a gut microbiota | |
| 650 | 4 | |a infant | |
| 650 | 4 | |a milk | |
| 650 | 4 | |a supplements | |
| 650 | 7 | |a Vitamin D |2 NLM | |
| 650 | 7 | |a 1406-16-2 |2 NLM | |
| 700 | 1 | |a Field, Catherine J |e verfasserin |4 aut | |
| 700 | 1 | |a Haqq, Andrea M |e verfasserin |4 aut | |
| 700 | 1 | |a de Souza, Russell J |e verfasserin |4 aut | |
| 700 | 1 | |a Tun, Hein M |e verfasserin |4 aut | |
| 700 | 1 | |a Morales-Lizcano, Nadia P |e verfasserin |4 aut | |
| 700 | 1 | |a Konya, Theodore B |e verfasserin |4 aut | |
| 700 | 1 | |a Guttman, David S |e verfasserin |4 aut | |
| 700 | 1 | |a Azad, Meghan B |e verfasserin |4 aut | |
| 700 | 1 | |a Becker, Allan B |e verfasserin |4 aut | |
| 700 | 1 | |a Lefebvre, Diana L |e verfasserin |4 aut | |
| 700 | 1 | |a Mandhane, Piush J |e verfasserin |4 aut | |
| 700 | 1 | |a Moraes, Theo J |e verfasserin |4 aut | |
| 700 | 1 | |a Sears, Malcolm R |e verfasserin |4 aut | |
| 700 | 1 | |a Turvey, Stuart E |e verfasserin |4 aut | |
| 700 | 1 | |a Subbarao, Padmaja |e verfasserin |4 aut | |
| 700 | 1 | |a Scott, James A |e verfasserin |4 aut | |
| 700 | 1 | |a Kozyrskyj, Anita L |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Gut microbes |d 2010 |g 12(2020), 1 vom: 09. Nov., Seite 1799734 |w (DE-627)NLM199892369 |x 1949-0984 |7 nnns |
| 773 | 1 | 8 | |g volume:12 |g year:2020 |g number:1 |g day:09 |g month:11 |g pages:1799734 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/19490976.2020.1799734 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 12 |j 2020 |e 1 |b 09 |c 11 |h 1799734 | ||