Type II diabetes accentuates diaphragm blood flow increases during submaximal exercise in the rat
Copyright © 2020 Elsevier B.V. All rights reserved..
We investigated the effect of type 2 diabetes mellitus (T2DM) on respiratory muscle blood flow (BF) during exercise. Using the Goto-Kakizaki (GK) rat model of T2DM, we hypothesized that diaphragm, intercostal and transverse abdominis BFs (radiolabeled microspheres) would be higher in male GK rats (n = 10) compared to healthy male Wistar controls (CON; n = 8) during submaximal exercise (20 m/min, 10 % grade). Blood glucose was significantly higher in GK (246 ± 29 mg/dL) compared to CON (103 ± 4 mg/dL; P < 0.01). Respiratory muscle BFs were not different at rest (P> 0.50). From rest to submaximal exercise, respiratory muscle BFs increased in both groups to all muscles (P < 0.01). During submaximal exercise GK rats had higher diaphragm BFs (GK: 189 ± 13; CON: 138 ± 14 mL/min/100 g, P < 0.01), and vascular conductance (GK: 1.4 ± 0.1; CON: 1.0 ± 0.1 mL/min/mmHg/100 g; P < 0.01) compared to CON. There were no differences in intercostal or transverse abdominis BF or VC during exercise (P> 0.15). These findings suggest that submaximal exercise requires a higher diaphragm BF and VC in T2DM compared to healthy counterparts.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:281 |
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| Enthalten in: |
Respiratory physiology & neurobiology - 281(2020) vom: 15. Okt., Seite 103518 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Butenas, Alec L E [VerfasserIn] |
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| Links: |
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| Themen: |
Diabetic rat |
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| Anmerkungen: |
Date Completed 04.10.2021 Date Revised 29.01.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.resp.2020.103518 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM313521832 |
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| 245 | 1 | 0 | |a Type II diabetes accentuates diaphragm blood flow increases during submaximal exercise in the rat |
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| 500 | |a Date Revised 29.01.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier B.V. All rights reserved. | ||
| 520 | |a We investigated the effect of type 2 diabetes mellitus (T2DM) on respiratory muscle blood flow (BF) during exercise. Using the Goto-Kakizaki (GK) rat model of T2DM, we hypothesized that diaphragm, intercostal and transverse abdominis BFs (radiolabeled microspheres) would be higher in male GK rats (n = 10) compared to healthy male Wistar controls (CON; n = 8) during submaximal exercise (20 m/min, 10 % grade). Blood glucose was significantly higher in GK (246 ± 29 mg/dL) compared to CON (103 ± 4 mg/dL; P < 0.01). Respiratory muscle BFs were not different at rest (P> 0.50). From rest to submaximal exercise, respiratory muscle BFs increased in both groups to all muscles (P < 0.01). During submaximal exercise GK rats had higher diaphragm BFs (GK: 189 ± 13; CON: 138 ± 14 mL/min/100 g, P < 0.01), and vascular conductance (GK: 1.4 ± 0.1; CON: 1.0 ± 0.1 mL/min/mmHg/100 g; P < 0.01) compared to CON. There were no differences in intercostal or transverse abdominis BF or VC during exercise (P> 0.15). These findings suggest that submaximal exercise requires a higher diaphragm BF and VC in T2DM compared to healthy counterparts | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Diabetic rat | |
| 650 | 4 | |a Exercise tolerance | |
| 650 | 4 | |a Goto-Kakizaki | |
| 650 | 4 | |a Intercostals | |
| 650 | 4 | |a Respiratory muscles | |
| 650 | 4 | |a Vascular conductance | |
| 700 | 1 | |a Smith, Joshua R |e verfasserin |4 aut | |
| 700 | 1 | |a Copp, Steven W |e verfasserin |4 aut | |
| 700 | 1 | |a Sue Hageman, K |e verfasserin |4 aut | |
| 700 | 1 | |a Poole, David C |e verfasserin |4 aut | |
| 700 | 1 | |a Musch, Timothy I |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:281 |g year:2020 |g day:15 |g month:10 |g pages:103518 |
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