A putative role for the tobacco mosaic virus in smokers' resistance to COVID-19
Copyright © 2020 Elsevier Ltd. All rights reserved..
Reports from various countries suggest that tobacco smoking might protect from SARS-CoV-2 infection, since the prevalence of smoking in COVID-19 hospitalized patients is lower than in the respective general population. Apart from nicotine or other chemicals contained in tobacco smoke, we propose that a single-stranded RNA virus that infects tobacco leaves, tobacco mosaic virus (TMV), might be implicated in this effect. TMV, though non-pathogenic, is found in smokers' airways, and stimulates adaptive and innate immunity, with release of specific antibodies and interferons. The latter may have preventive and/or therapeutic effects against COVID-19. If confirmed by epidemiological and interventional studies, this might lead to the use of TMV as an immunological adjuvant against SARS-CoV-2 infection and COVID-19 disease.
| Errataetall: |
CommentIn: Med Hypotheses. 2020 Nov;144:110251. - PMID 33254556 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:143 |
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| Enthalten in: |
Medical hypotheses - 143(2020) vom: 25. Okt., Seite 110153 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
de Bernardis, E [VerfasserIn] |
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| Links: |
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| Themen: |
9008-11-1 |
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| Anmerkungen: |
Date Completed 13.10.2020 Date Revised 28.03.2023 published: Print-Electronic CommentIn: Med Hypotheses. 2020 Nov;144:110251. - PMID 33254556 Citation Status MEDLINE |
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| doi: |
10.1016/j.mehy.2020.110153 |
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| funding: |
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NLM31338732X |
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| 500 | |a CommentIn: Med Hypotheses. 2020 Nov;144:110251. - PMID 33254556 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier Ltd. All rights reserved. | ||
| 520 | |a Reports from various countries suggest that tobacco smoking might protect from SARS-CoV-2 infection, since the prevalence of smoking in COVID-19 hospitalized patients is lower than in the respective general population. Apart from nicotine or other chemicals contained in tobacco smoke, we propose that a single-stranded RNA virus that infects tobacco leaves, tobacco mosaic virus (TMV), might be implicated in this effect. TMV, though non-pathogenic, is found in smokers' airways, and stimulates adaptive and innate immunity, with release of specific antibodies and interferons. The latter may have preventive and/or therapeutic effects against COVID-19. If confirmed by epidemiological and interventional studies, this might lead to the use of TMV as an immunological adjuvant against SARS-CoV-2 infection and COVID-19 disease | ||
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