Patterns of viral clearance in the natural course of asymptomatic COVID-19 : Comparison with symptomatic non-severe COVID-19
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved..
OBJECTIVES: The aim of this study was to elucidate patterns of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) clearance in the natural course of asymptomatic coronavirus disease 2019 (COVID-19).
METHODS: Consecutive patients with non-severe COVID-19 were included retrospectively. Asymptomatic patients with a normal body temperature and no evidence of pneumonia throughout the disease course were assigned to the asymptomatic group. The reverse transcription PCR (RT-PCR) assay was repeated every two to five days after the first follow-up RT-PCR assay. Negative conversion was defined as two consecutive negative RT-PCR assay results within a 24-h interval. Rebound of the cycle threshold (Ct) value was defined as negative from the single RT-PCR assay and positive from the following assay.
RESULTS: Among a total of 396 patients identified (median age 42.5 years (interquartile range (IQR) 25.0-55.0 years), 35.6% male), 68 (17.2%) were assigned to the asymptomatic group and 328 (82.8%) to the symptomatic group. The time until negative conversion was significantly shorter in the asymptomatic group than in the symptomatic group: median 14.5 days (IQR 11.0-21.0 days) and 18.0 days (IQR 15.0-22.0 days), respectively (p = 0.001). Rebound of Ct values was observed in 78 patients (19.7%).
CONCLUSIONS: Time until negative conversion is shorter in asymptomatic COVID-19 than in symptomatic COVID-19. Rebound of Ct values is not uncommon.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:99 |
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| Enthalten in: |
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 99(2020) vom: 10. Okt., Seite 279-285 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Uhm, Jae-Sun [VerfasserIn] |
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| Links: |
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| Themen: |
Asymptomatic |
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| Anmerkungen: |
Date Completed 02.11.2020 Date Revised 10.01.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijid.2020.07.070 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM313385165 |
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| 100 | 1 | |a Uhm, Jae-Sun |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Patterns of viral clearance in the natural course of asymptomatic COVID-19 |b Comparison with symptomatic non-severe COVID-19 |
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| 500 | |a Date Completed 02.11.2020 | ||
| 500 | |a Date Revised 10.01.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a OBJECTIVES: The aim of this study was to elucidate patterns of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) clearance in the natural course of asymptomatic coronavirus disease 2019 (COVID-19) | ||
| 520 | |a METHODS: Consecutive patients with non-severe COVID-19 were included retrospectively. Asymptomatic patients with a normal body temperature and no evidence of pneumonia throughout the disease course were assigned to the asymptomatic group. The reverse transcription PCR (RT-PCR) assay was repeated every two to five days after the first follow-up RT-PCR assay. Negative conversion was defined as two consecutive negative RT-PCR assay results within a 24-h interval. Rebound of the cycle threshold (Ct) value was defined as negative from the single RT-PCR assay and positive from the following assay | ||
| 520 | |a RESULTS: Among a total of 396 patients identified (median age 42.5 years (interquartile range (IQR) 25.0-55.0 years), 35.6% male), 68 (17.2%) were assigned to the asymptomatic group and 328 (82.8%) to the symptomatic group. The time until negative conversion was significantly shorter in the asymptomatic group than in the symptomatic group: median 14.5 days (IQR 11.0-21.0 days) and 18.0 days (IQR 15.0-22.0 days), respectively (p = 0.001). Rebound of Ct values was observed in 78 patients (19.7%) | ||
| 520 | |a CONCLUSIONS: Time until negative conversion is shorter in asymptomatic COVID-19 than in symptomatic COVID-19. Rebound of Ct values is not uncommon | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Asymptomatic | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Coronavirus disease 2019 | |
| 650 | 4 | |a Negative conversion | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a Viral clearance | |
| 700 | 1 | |a Ahn, Jin Young |e verfasserin |4 aut | |
| 700 | 1 | |a Hyun, JongHoon |e verfasserin |4 aut | |
| 700 | 1 | |a Sohn, Yujin |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Jung Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Jeong, Su Jin |e verfasserin |4 aut | |
| 700 | 1 | |a Ku, Nam Su |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Jun Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Yu-Kyung |e verfasserin |4 aut | |
| 700 | 1 | |a Yi, Ho-Sung |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Sung Kyu |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Bong-Ok |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Hyewon |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Jinwoo |e verfasserin |4 aut | |
| 700 | 1 | |a Kang, Seung-Mo |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Yeong Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Yoon, Hae Kyoung |e verfasserin |4 aut | |
| 700 | 1 | |a Jung, Sunkyung |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Hyeong Nyeon |e verfasserin |4 aut | |
| 700 | 1 | |a Yeom, Joon-Sup |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Yoon Soo |e verfasserin |4 aut | |
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