Recurrent HyperCKemia with Immunological Involvement of the Endomysial Capillaries in Neuromyelitis Optica
A 55-year-old woman with neuromyelitis optica (NMO) had recurrent myalgias with hyperCKemia. A muscle biopsy suggested nonspecific myopathic changes. Regarding immunohistochemistry, the expression of both major histocompatibility complex class I and myxovirus resistance protein A was observed in the endomysial capillaries, suggesting immunological involvement of these capillaries, whereas both C5b9 (membrane attack complex) and aquaporin 4 immunofluorescence stainings were normal. The present findings led us to conclude that one possible mechanism for hyperCKemia in NMO underlying the immunological involvement of the endomysial capillaries was an as-yet-unidentified factor that triggered damage to the integrity of the sarcolemma and thereby cause CK leakage into the serum.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:59 |
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| Enthalten in: |
Internal medicine (Tokyo, Japan) - 59(2020), 23 vom: 01. Dez., Seite 3079-3083 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kinno, Ryuta [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 02.04.2021 Date Revised 02.04.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.2169/internalmedicine.4600-20 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM313347042 |
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| 245 | 1 | 0 | |a Recurrent HyperCKemia with Immunological Involvement of the Endomysial Capillaries in Neuromyelitis Optica |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A 55-year-old woman with neuromyelitis optica (NMO) had recurrent myalgias with hyperCKemia. A muscle biopsy suggested nonspecific myopathic changes. Regarding immunohistochemistry, the expression of both major histocompatibility complex class I and myxovirus resistance protein A was observed in the endomysial capillaries, suggesting immunological involvement of these capillaries, whereas both C5b9 (membrane attack complex) and aquaporin 4 immunofluorescence stainings were normal. The present findings led us to conclude that one possible mechanism for hyperCKemia in NMO underlying the immunological involvement of the endomysial capillaries was an as-yet-unidentified factor that triggered damage to the integrity of the sarcolemma and thereby cause CK leakage into the serum | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a endomysial capillaries | |
| 650 | 4 | |a hyperCKemia | |
| 650 | 4 | |a major histocompatibility complex class I | |
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| 650 | 4 | |a neuromyelitis optica | |
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| 700 | 1 | |a Osakabe, Yuyuko |e verfasserin |4 aut | |
| 700 | 1 | |a Takahashi, Seiya |e verfasserin |4 aut | |
| 700 | 1 | |a Kurokawa, Shinji |e verfasserin |4 aut | |
| 700 | 1 | |a Owan, Yoshiyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Shimizu, Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Ono, Kenjiro |e verfasserin |4 aut | |
| 700 | 1 | |a Baba, Yasuhiko |e verfasserin |4 aut | |
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