Blast exposure results in tau and neurofilament light chain changes in peripheral blood
OBJECTIVES: To evaluate how blast exposure impacts peripheral biomarkers.
in military personnel enrolled in 10-day blast training.
METHODS: On day 7, 21 military personnel experienced peak overpressure <2 pounds per square inch (psi); while 29 military personnel experienced peak overpressure ≥5 psi. Blood samples were collected each day to measure changes in amyloid beta (Aβ), neurofilament light chain (NFL), and tau concentrations.
RESULTS: Within 24 hours following exposure ≥5 psi, the ≥5 psi group had lower Aβ42 (p = .004) and NFL (p < .001) compared to the <2 psi group and lower Aβ42 (9.35%) and NFL (22.01%) compared to baseline. Twenty-four hours after ≥5 psi exposure, the ≥5 psi group had lower tau (p < .001) and NFL (p < .001) compared to the <2 psi group and baseline. Seventy-two hours after exposure ≥5 psi, tau increased in the ≥5 psi group compared to the <2 psi group (p = .02) and baseline. The tau:Aβ42 ratio 24 hours after blast (p = .012), and the Aβ40:Aβ42 ratio 48 hours after blast (p = .04) differed in the ≥5 psi group compared to the <2 psi group.
CONCLUSIONS: These findings provide an initial report of acute alterations in biomarker concentrations following blast exposure.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
|---|---|
| Enthalten in: |
Brain injury - 34(2020), 9 vom: 28. Juli, Seite 1213-1221 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Edwards, Katie A [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 28.07.2021 Date Revised 28.07.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/02699052.2020.1797171 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM313306273 |
|---|
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| 100 | 1 | |a Edwards, Katie A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Blast exposure results in tau and neurofilament light chain changes in peripheral blood |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 28.07.2021 | ||
| 500 | |a Date Revised 28.07.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: To evaluate how blast exposure impacts peripheral biomarkers | ||
| 520 | |a in military personnel enrolled in 10-day blast training | ||
| 520 | |a METHODS: On day 7, 21 military personnel experienced peak overpressure <2 pounds per square inch (psi); while 29 military personnel experienced peak overpressure ≥5 psi. Blood samples were collected each day to measure changes in amyloid beta (Aβ), neurofilament light chain (NFL), and tau concentrations | ||
| 520 | |a RESULTS: Within 24 hours following exposure ≥5 psi, the ≥5 psi group had lower Aβ42 (p = .004) and NFL (p < .001) compared to the <2 psi group and lower Aβ42 (9.35%) and NFL (22.01%) compared to baseline. Twenty-four hours after ≥5 psi exposure, the ≥5 psi group had lower tau (p < .001) and NFL (p < .001) compared to the <2 psi group and baseline. Seventy-two hours after exposure ≥5 psi, tau increased in the ≥5 psi group compared to the <2 psi group (p = .02) and baseline. The tau:Aβ42 ratio 24 hours after blast (p = .012), and the Aβ40:Aβ42 ratio 48 hours after blast (p = .04) differed in the ≥5 psi group compared to the <2 psi group | ||
| 520 | |a CONCLUSIONS: These findings provide an initial report of acute alterations in biomarker concentrations following blast exposure | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Intramural | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 4 | |a Blast exposure | |
| 650 | 4 | |a military | |
| 650 | 4 | |a neurofilament light chain (NFL) | |
| 650 | 4 | |a peripheral biomarkers | |
| 650 | 4 | |a tau | |
| 650 | 7 | |a Amyloid beta-Peptides |2 NLM | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a Neurofilament Proteins |2 NLM | |
| 650 | 7 | |a tau Proteins |2 NLM | |
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| 700 | 1 | |a Tschiffely, Anna E |e verfasserin |4 aut | |
| 700 | 1 | |a Moore, Candace Y |e verfasserin |4 aut | |
| 700 | 1 | |a Dell, Kristine C |e verfasserin |4 aut | |
| 700 | 1 | |a Statz, Jonathan K |e verfasserin |4 aut | |
| 700 | 1 | |a Carr, Walter |e verfasserin |4 aut | |
| 700 | 1 | |a Walker, Peter B |e verfasserin |4 aut | |
| 700 | 1 | |a LoPresti, Matthew L |e verfasserin |4 aut | |
| 700 | 1 | |a Ahlers, Stephen T |e verfasserin |4 aut | |
| 700 | 1 | |a Yarnell, Angela M |e verfasserin |4 aut | |
| 700 | 1 | |a Gill, Jessica |e verfasserin |4 aut | |
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