Presenting features of COVID-19 in older people : relationships with frailty, inflammation and mortality
PURPOSE: To describe the clinical features of COVID-19 in older adults, and relate these to outcomes.
METHODS: A cohort study of 217 individuals (median age 80, IQR 74-85 years; 62% men) hospitalised with COVID-19, followed up for all-cause mortality, was conducted. Secondary outcomes included cognitive and physical function at discharge. C-reactive protein and neutrophil:lymphocyte ratio were used as measures of immune activity.
RESULTS: Cardinal COVID-19 symptoms (fever, dyspnoea, cough) were common but not universal. Inflammation on hospitalisation was lower in frail older adults. Fever, dyspnoea, delirium and inflammation were associated with mortality. Delirium at presentation was an independent risk factor for cognitive decline at discharge.
CONCLUSIONS: COVID-19 may present without cardinal symptoms as well as implicate a possible role for age-related changes in immunity in mediating the relationship between frailty and mortality.
| Errataetall: |
CommentIn: Eur Geriatr Med. 2021 Feb;12(1):213-214. - PMID 33393061 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
European geriatric medicine - 11(2020), 6 vom: 31. Dez., Seite 1089-1094 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Knopp, Paul [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 21.12.2020 Date Revised 15.11.2023 published: Print-Electronic CommentIn: Eur Geriatr Med. 2021 Feb;12(1):213-214. - PMID 33393061 Citation Status MEDLINE |
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| doi: |
10.1007/s41999-020-00373-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM313099804 |
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| 500 | |a Date Completed 21.12.2020 | ||
| 500 | |a Date Revised 15.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Eur Geriatr Med. 2021 Feb;12(1):213-214. - PMID 33393061 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: To describe the clinical features of COVID-19 in older adults, and relate these to outcomes | ||
| 520 | |a METHODS: A cohort study of 217 individuals (median age 80, IQR 74-85 years; 62% men) hospitalised with COVID-19, followed up for all-cause mortality, was conducted. Secondary outcomes included cognitive and physical function at discharge. C-reactive protein and neutrophil:lymphocyte ratio were used as measures of immune activity | ||
| 520 | |a RESULTS: Cardinal COVID-19 symptoms (fever, dyspnoea, cough) were common but not universal. Inflammation on hospitalisation was lower in frail older adults. Fever, dyspnoea, delirium and inflammation were associated with mortality. Delirium at presentation was an independent risk factor for cognitive decline at discharge | ||
| 520 | |a CONCLUSIONS: COVID-19 may present without cardinal symptoms as well as implicate a possible role for age-related changes in immunity in mediating the relationship between frailty and mortality | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Epidemiology | |
| 650 | 4 | |a Immune dysfunction | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Post-hospitalisation outcomes | |
| 700 | 1 | |a Miles, Amy |e verfasserin |4 aut | |
| 700 | 1 | |a Webb, Thomas E |e verfasserin |4 aut | |
| 700 | 1 | |a Mcloughlin, Benjamin C |e verfasserin |4 aut | |
| 700 | 1 | |a Mannan, Imran |e verfasserin |4 aut | |
| 700 | 1 | |a Raja, Nadia |e verfasserin |4 aut | |
| 700 | 1 | |a Wan, Bettina |e verfasserin |4 aut | |
| 700 | 1 | |a Davis, Daniel |e verfasserin |4 aut | |
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