Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques
A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be required to end the coronavirus disease 2019 (COVID-19) pandemic1-8. For global deployment and pandemic control, a vaccine that requires only a single immunization would be optimal. Here we show the immunogenicity and protective efficacy of a single dose of adenovirus serotype 26 (Ad26) vector-based vaccines expressing the SARS-CoV-2 spike (S) protein in non-human primates. Fifty-two rhesus macaques (Macaca mulatta) were immunized with Ad26 vectors that encoded S variants or sham control, and then challenged with SARS-CoV-2 by the intranasal and intratracheal routes9,10. The optimal Ad26 vaccine induced robust neutralizing antibody responses and provided complete or near-complete protection in bronchoalveolar lavage and nasal swabs after SARS-CoV-2 challenge. Titres of vaccine-elicited neutralizing antibodies correlated with protective efficacy, suggesting an immune correlate of protection. These data demonstrate robust single-shot vaccine protection against SARS-CoV-2 in non-human primates. The optimal Ad26 vector-based vaccine for SARS-CoV-2, termed Ad26.COV2.S, is currently being evaluated in clinical trials.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:586 |
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| Enthalten in: |
Nature - 586(2020), 7830 vom: 05. Okt., Seite 583-588 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mercado, Noe B [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 Vaccines |
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| Anmerkungen: |
Date Completed 29.10.2020 Date Revised 15.06.2023 published: Print-Electronic ErratumIn: Nature. 2021 Feb;590(7844):E25. - PMID 33469218 Citation Status MEDLINE |
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| doi: |
10.1038/s41586-020-2607-z |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM313068100 |
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| 245 | 1 | 0 | |a Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques |
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| 500 | |a Date Completed 29.10.2020 | ||
| 500 | |a Date Revised 15.06.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ErratumIn: Nature. 2021 Feb;590(7844):E25. - PMID 33469218 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be required to end the coronavirus disease 2019 (COVID-19) pandemic1-8. For global deployment and pandemic control, a vaccine that requires only a single immunization would be optimal. Here we show the immunogenicity and protective efficacy of a single dose of adenovirus serotype 26 (Ad26) vector-based vaccines expressing the SARS-CoV-2 spike (S) protein in non-human primates. Fifty-two rhesus macaques (Macaca mulatta) were immunized with Ad26 vectors that encoded S variants or sham control, and then challenged with SARS-CoV-2 by the intranasal and intratracheal routes9,10. The optimal Ad26 vaccine induced robust neutralizing antibody responses and provided complete or near-complete protection in bronchoalveolar lavage and nasal swabs after SARS-CoV-2 challenge. Titres of vaccine-elicited neutralizing antibodies correlated with protective efficacy, suggesting an immune correlate of protection. These data demonstrate robust single-shot vaccine protection against SARS-CoV-2 in non-human primates. The optimal Ad26 vector-based vaccine for SARS-CoV-2, termed Ad26.COV2.S, is currently being evaluated in clinical trials | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a COVID-19 Vaccines |2 NLM | |
| 650 | 7 | |a Viral Vaccines |2 NLM | |
| 700 | 1 | |a Zahn, Roland |e verfasserin |4 aut | |
| 700 | 1 | |a Wegmann, Frank |e verfasserin |4 aut | |
| 700 | 1 | |a Loos, Carolin |e verfasserin |4 aut | |
| 700 | 1 | |a Chandrashekar, Abishek |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Jingyou |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Jinyan |e verfasserin |4 aut | |
| 700 | 1 | |a Peter, Lauren |e verfasserin |4 aut | |
| 700 | 1 | |a McMahan, Katherine |e verfasserin |4 aut | |
| 700 | 1 | |a Tostanoski, Lisa H |e verfasserin |4 aut | |
| 700 | 1 | |a He, Xuan |e verfasserin |4 aut | |
| 700 | 1 | |a Martinez, David R |e verfasserin |4 aut | |
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| 700 | 1 | |a Bos, Rinke |e verfasserin |4 aut | |
| 700 | 1 | |a van Manen, Danielle |e verfasserin |4 aut | |
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| 700 | 1 | |a Hauser, Blake M |e verfasserin |4 aut | |
| 700 | 1 | |a Caradonna, Timothy M |e verfasserin |4 aut | |
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| 700 | 1 | |a Dagotto, Gabriel |e verfasserin |4 aut | |
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| 700 | 1 | |a Nkolola, Joseph P |e verfasserin |4 aut | |
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