Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells
Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Emerging infectious diseases - 26(2020), 12 vom: 15. Dez., Seite 2961-2965 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lau, Susanna K P [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 01.01.2021 Date Revised 07.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.3201/eid2612.202308 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM313062862 |
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| 520 | |a Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism | ||
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| 700 | 1 | |a Luk, Hayes K H |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Kenneth S M |e verfasserin |4 aut | |
| 700 | 1 | |a Fung, Joshua |e verfasserin |4 aut | |
| 700 | 1 | |a He, Zirong |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Flora K K |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, Tony T Y |e verfasserin |4 aut | |
| 700 | 1 | |a Chu, Stella |e verfasserin |4 aut | |
| 700 | 1 | |a Aw-Yong, Kam Leng |e verfasserin |4 aut | |
| 700 | 1 | |a Lau, Terrence C K |e verfasserin |4 aut | |
| 700 | 1 | |a Fung, Kitty S C |e verfasserin |4 aut | |
| 700 | 1 | |a Woo, Patrick C Y |e verfasserin |4 aut | |
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