Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS
PURPOSE: The main characteristics of mechanically ventilated ARDS patients affected with COVID-19, and the adherence to lung-protective ventilation strategies are not well known. We describe characteristics and outcomes of confirmed ARDS in COVID-19 patients managed with invasive mechanical ventilation (MV).
METHODS: This is a multicenter, prospective, observational study in consecutive, mechanically ventilated patients with ARDS (as defined by the Berlin criteria) affected with with COVID-19 (confirmed SARS-CoV-2 infection in nasal or pharyngeal swab specimens), admitted to a network of 36 Spanish and Andorran intensive care units (ICUs) between March 12 and June 1, 2020. We examined the clinical features, ventilatory management, and clinical outcomes of COVID-19 ARDS patients, and compared some results with other relevant studies in non-COVID-19 ARDS patients.
RESULTS: A total of 742 patients were analysed with complete 28-day outcome data: 128 (17.1%) with mild, 331 (44.6%) with moderate, and 283 (38.1%) with severe ARDS. At baseline, defined as the first day on invasive MV, median (IQR) values were: tidal volume 6.9 (6.3-7.8) ml/kg predicted body weight, positive end-expiratory pressure 12 (11-14) cmH2O. Values of respiratory system compliance 35 (27-45) ml/cmH2O, plateau pressure 25 (22-29) cmH2O, and driving pressure 12 (10-16) cmH2O were similar to values from non-COVID-19 ARDS patients observed in other studies. Recruitment maneuvers, prone position and neuromuscular blocking agents were used in 79%, 76% and 72% of patients, respectively. The risk of 28-day mortality was lower in mild ARDS [hazard ratio (RR) 0.56 (95% CI 0.33-0.93), p = 0.026] and moderate ARDS [hazard ratio (RR) 0.69 (95% CI 0.47-0.97), p = 0.035] when compared to severe ARDS. The 28-day mortality was similar to other observational studies in non-COVID-19 ARDS patients.
CONCLUSIONS: In this large series, COVID-19 ARDS patients have features similar to other causes of ARDS, compliance with lung-protective ventilation was high, and the risk of 28-day mortality increased with the degree of ARDS severity.
Errataetall: |
CommentIn: Intensive Care Med. 2020 Dec;46(12):2197-2199. - PMID 33006682 |
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Medienart: |
E-Artikel |
Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
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Enthalten in: |
Intensive care medicine - 46(2020), 12 vom: 29. Dez., Seite 2200-2211 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Ferrando, Carlos [VerfasserIn] |
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Links: |
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Themen: |
Acute respiratory distress syndrome |
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Anmerkungen: |
Date Completed 23.12.2020 Date Revised 16.07.2022 published: Print-Electronic ClinicalTrials.gov: NCT04368975 CommentIn: Intensive Care Med. 2020 Dec;46(12):2197-2199. - PMID 33006682 Citation Status MEDLINE |
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doi: |
10.1007/s00134-020-06192-2 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM313045720 |
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100 | 1 | |a Ferrando, Carlos |e verfasserin |4 aut | |
245 | 1 | 0 | |a Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS |
264 | 1 | |c 2020 | |
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500 | |a Date Completed 23.12.2020 | ||
500 | |a Date Revised 16.07.2022 | ||
500 | |a published: Print-Electronic | ||
500 | |a ClinicalTrials.gov: NCT04368975 | ||
500 | |a CommentIn: Intensive Care Med. 2020 Dec;46(12):2197-2199. - PMID 33006682 | ||
500 | |a Citation Status MEDLINE | ||
520 | |a PURPOSE: The main characteristics of mechanically ventilated ARDS patients affected with COVID-19, and the adherence to lung-protective ventilation strategies are not well known. We describe characteristics and outcomes of confirmed ARDS in COVID-19 patients managed with invasive mechanical ventilation (MV) | ||
520 | |a METHODS: This is a multicenter, prospective, observational study in consecutive, mechanically ventilated patients with ARDS (as defined by the Berlin criteria) affected with with COVID-19 (confirmed SARS-CoV-2 infection in nasal or pharyngeal swab specimens), admitted to a network of 36 Spanish and Andorran intensive care units (ICUs) between March 12 and June 1, 2020. We examined the clinical features, ventilatory management, and clinical outcomes of COVID-19 ARDS patients, and compared some results with other relevant studies in non-COVID-19 ARDS patients | ||
520 | |a RESULTS: A total of 742 patients were analysed with complete 28-day outcome data: 128 (17.1%) with mild, 331 (44.6%) with moderate, and 283 (38.1%) with severe ARDS. At baseline, defined as the first day on invasive MV, median (IQR) values were: tidal volume 6.9 (6.3-7.8) ml/kg predicted body weight, positive end-expiratory pressure 12 (11-14) cmH2O. Values of respiratory system compliance 35 (27-45) ml/cmH2O, plateau pressure 25 (22-29) cmH2O, and driving pressure 12 (10-16) cmH2O were similar to values from non-COVID-19 ARDS patients observed in other studies. Recruitment maneuvers, prone position and neuromuscular blocking agents were used in 79%, 76% and 72% of patients, respectively. The risk of 28-day mortality was lower in mild ARDS [hazard ratio (RR) 0.56 (95% CI 0.33-0.93), p = 0.026] and moderate ARDS [hazard ratio (RR) 0.69 (95% CI 0.47-0.97), p = 0.035] when compared to severe ARDS. The 28-day mortality was similar to other observational studies in non-COVID-19 ARDS patients | ||
520 | |a CONCLUSIONS: In this large series, COVID-19 ARDS patients have features similar to other causes of ARDS, compliance with lung-protective ventilation was high, and the risk of 28-day mortality increased with the degree of ARDS severity | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Multicenter Study | |
650 | 4 | |a Observational Study | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Acute respiratory distress syndrome | |
650 | 4 | |a Coronavirus | |
650 | 4 | |a Mechanical ventilation | |
650 | 4 | |a Outcome | |
700 | 1 | |a Suarez-Sipmann, Fernando |e verfasserin |4 aut | |
700 | 1 | |a Mellado-Artigas, Ricard |e verfasserin |4 aut | |
700 | 1 | |a Hernández, María |e verfasserin |4 aut | |
700 | 1 | |a Gea, Alfredo |e verfasserin |4 aut | |
700 | 1 | |a Arruti, Egoitz |e verfasserin |4 aut | |
700 | 1 | |a Aldecoa, César |e verfasserin |4 aut | |
700 | 1 | |a Martínez-Pallí, Graciela |e verfasserin |4 aut | |
700 | 1 | |a Martínez-González, Miguel A |e verfasserin |4 aut | |
700 | 1 | |a Slutsky, Arthur S |e verfasserin |4 aut | |
700 | 1 | |a Villar, Jesús |e verfasserin |4 aut | |
700 | 0 | |a COVID-19 Spanish ICU Network |e verfasserin |4 aut | |
700 | 1 | |a Ferrando, Carlos |e investigator |4 oth | |
700 | 1 | |a Graciela |e investigator |4 oth | |
700 | 1 | |a Martínez-Pallí |e investigator |4 oth | |
700 | 1 | |a Mercadal, Jordi |e investigator |4 oth | |
700 | 1 | |a Muñoz, Guido |e investigator |4 oth | |
700 | 1 | |a Mellado, Ricard |e investigator |4 oth | |
700 | 1 | |a Jacas, Adriana |e investigator |4 oth | |
700 | 1 | |a Vendrell, Marina |e investigator |4 oth | |
700 | 1 | |a Sánchez-Etayo, Gerard |e investigator |4 oth | |
700 | 1 | |a Alcón, Amalia |e investigator |4 oth | |
700 | 1 | |a Belda, Isabel |e investigator |4 oth | |
700 | 1 | |a Agustí, Mercé |e investigator |4 oth | |
700 | 1 | |a Carramiñana, Albert |e investigator |4 oth | |
700 | 1 | |a Gracia, Isabel |e investigator |4 oth | |
700 | 1 | |a Panzeri, Miriam |e investigator |4 oth | |
700 | 1 | |a León, Irene |e investigator |4 oth | |
700 | 1 | |a Balust, Jaume |e investigator |4 oth | |
700 | 1 | |a Navarro, Ricard |e investigator |4 oth | |
700 | 1 | |a Arguís, María José |e investigator |4 oth | |
700 | 1 | |a Carretero, Maria José |e investigator |4 oth | |
700 | 1 | |a Ibáñez, Cristina |e investigator |4 oth | |
700 | 1 | |a Perdomo, Juan |e investigator |4 oth | |
700 | 1 | |a López, Antonio |e investigator |4 oth | |
700 | 1 | |a López, Manuel |e investigator |4 oth | |
700 | 1 | |a Cuñat, Tomás |e investigator |4 oth | |
700 | 1 | |a Ubré, Marta |e investigator |4 oth | |
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700 | 1 | |a Calvo, Andrea |e investigator |4 oth | |
700 | 1 | |a Rivas, Eva |e investigator |4 oth | |
700 | 1 | |a Hurtado, Paola |e investigator |4 oth | |
700 | 1 | |a Pujol, Roger |e investigator |4 oth | |
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700 | 1 | |a Tercero, Javier |e investigator |4 oth | |
700 | 1 | |a Sanahuja, Pepe |e investigator |4 oth | |
700 | 1 | |a Magaldi, Marta |e investigator |4 oth | |
700 | 1 | |a Coca, Miquel |e investigator |4 oth | |
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700 | 1 | |a Caballero, Angel |e investigator |4 oth | |
700 | 1 | |a Risco, Raquel |e investigator |4 oth | |
700 | 1 | |a Gómez, Lidia |e investigator |4 oth | |
700 | 1 | |a de Riva, Nicolás |e investigator |4 oth | |
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700 | 1 | |a Beatriz |e investigator |4 oth | |
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700 | 1 | |a Ceravalls, Joan |e investigator |4 oth | |
700 | 1 | |a Comino, Oscar |e investigator |4 oth | |
700 | 1 | |a Cucciniello, Claudia |e investigator |4 oth | |
700 | 1 | |a De Deray, Clàudia |e investigator |4 oth | |
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700 | 1 | |a De la Matta, Paula |e investigator |4 oth | |
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700 | 1 | |a Fernández, Sara |e investigator |4 oth | |
700 | 1 | |a Fernández, Anna |e investigator |4 oth | |
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700 | 1 | |a Forga, María Tallo |e investigator |4 oth | |
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