Coronary Dilatation and Endothelial Inflammation in Neonates Born to Mothers with Preeclampsia
Copyright © 2020 Elsevier Inc. All rights reserved..
OBJECTIVES: To investigate the cardiovascular features and endothelium in neonates born to mothers with preeclampsia.
STUDY DESIGN: In this combined observational cohort and case-control study, neonates born to mothers with normotension and mothers with preeclampsia were recruited at a neonatal intensive care unit of a tertiary medical center. Cardiovascular measurements by echocardiography and the clinical measures upon admission were analyzed. Vascular cell adhesion molecule-1 expression in umbilical arteries and in in vitro endothelial cell stimulation with plasma were examined. Continuous data were compared using nonparametric analysis, and their relationships were analyzed using linear regression. Binary logistic regression was performed in the model of adjustment of birth body weight and for multivariate analysis.
RESULTS: In the cohort, almost all cardiovascular segments positively correlated to birth weight. Notably, neonates (n = 65) of mothers with preeclampsia had significantly larger coronary arteries at birth than neonates of mothers with normotension (n = 404) (median size of left main coronary artery 1.36 mm versus 1.08 mm, p <0.001; median size of right coronary artery, RCA 1.25 mm versus 1.0 mm, p <0.001). The size of the right coronary artery positively correlated to the maternal antepartum diastolic blood pressure (r = 0.298, P = .018) and was associated with in-hospital death (P < .001). Meanwhile, endothelial vascular cell adhesion molecule-1 expression was significantly increased in the umbilical arteries of the preeclamptic group and following preeclamptic cord-plasma stimulation. The latter also correlated with their relative coronary sizes.
CONCLUSIONS: Neonates of mothers with preeclampsia had distinctive coronary dilatation at birth. Coronary size might be useful as a severity index of neonatal endothelial inflammation as a result of maternal preeclampsia.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:228 |
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| Enthalten in: |
The Journal of pediatrics - 228(2021) vom: 15. Jan., Seite 58-65.e3 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lin, I-Chun [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 02.02.2021 Date Revised 02.02.2021 published: Print-Electronic CommentIn: J Pediatr. 2021 Jan;228:11-12. - PMID 32795476 Citation Status MEDLINE |
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| doi: |
10.1016/j.jpeds.2020.07.059 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM312882211 |
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| 100 | 1 | |a Lin, I-Chun |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Coronary Dilatation and Endothelial Inflammation in Neonates Born to Mothers with Preeclampsia |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 02.02.2021 | ||
| 500 | |a Date Revised 02.02.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: J Pediatr. 2021 Jan;228:11-12. - PMID 32795476 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVES: To investigate the cardiovascular features and endothelium in neonates born to mothers with preeclampsia | ||
| 520 | |a STUDY DESIGN: In this combined observational cohort and case-control study, neonates born to mothers with normotension and mothers with preeclampsia were recruited at a neonatal intensive care unit of a tertiary medical center. Cardiovascular measurements by echocardiography and the clinical measures upon admission were analyzed. Vascular cell adhesion molecule-1 expression in umbilical arteries and in in vitro endothelial cell stimulation with plasma were examined. Continuous data were compared using nonparametric analysis, and their relationships were analyzed using linear regression. Binary logistic regression was performed in the model of adjustment of birth body weight and for multivariate analysis | ||
| 520 | |a RESULTS: In the cohort, almost all cardiovascular segments positively correlated to birth weight. Notably, neonates (n = 65) of mothers with preeclampsia had significantly larger coronary arteries at birth than neonates of mothers with normotension (n = 404) (median size of left main coronary artery 1.36 mm versus 1.08 mm, p <0.001; median size of right coronary artery, RCA 1.25 mm versus 1.0 mm, p <0.001). The size of the right coronary artery positively correlated to the maternal antepartum diastolic blood pressure (r = 0.298, P = .018) and was associated with in-hospital death (P < .001). Meanwhile, endothelial vascular cell adhesion molecule-1 expression was significantly increased in the umbilical arteries of the preeclamptic group and following preeclamptic cord-plasma stimulation. The latter also correlated with their relative coronary sizes | ||
| 520 | |a CONCLUSIONS: Neonates of mothers with preeclampsia had distinctive coronary dilatation at birth. Coronary size might be useful as a severity index of neonatal endothelial inflammation as a result of maternal preeclampsia | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a cardiovascular disease | |
| 650 | 4 | |a coronary artery | |
| 650 | 4 | |a endothelial inflammation | |
| 650 | 4 | |a fetal/prenatal and developmental programming | |
| 650 | 4 | |a vascular cell adhesion molecule | |
| 700 | 1 | |a Hsu, Te-Yao |e verfasserin |4 aut | |
| 700 | 1 | |a Tain, You-Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Tsai, Ching-Chang |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Hsin-Chun |e verfasserin |4 aut | |
| 700 | 1 | |a Lai, Yun-Ju |e verfasserin |4 aut | |
| 700 | 1 | |a Chou, Ming-Huei |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Chien-Fu |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Hong-Ren |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Li-Tung |e verfasserin |4 aut | |
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