Quality of life in patients with uveitis : data from the ULISSE study (Uveitis: cLInical and medico-economic evaluation of a Standardised Strategy for the Etiological diagnosis)
© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ..
AIMS: To assess vision-related (VR-QOL) and health-related quality of life (HR-QOL) in a large series of patients with de novo uveitis at baseline and 6-month follow-up.
METHODS: Non-inferiority, prospective, multicentre, cluster randomised controlled trial registered under the Unique Identifier: NCT01162070. VR-QOL and HR-QOL were assessed by the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) and the Medical Outcomes Study 36-item Short Form Survey (SF-36).
RESULTS: At inclusion, 466 patients completed the VFQ-25. The mean composite score was 80.0 (±16.7). In multivariate analysis, higher age, female sex and insidious onset were significantly associated with lower QOL. At 6 months, 138 patients completed the VFQ-25, with a significantly higher mean composite score of 82.6 (±16.7). SF-36 mental component was 42.9 (±11.3) and physical component was 47.2 (±8.5) at inclusion (n=425). HR-QOL improvement at 6 months was not clinically significant.
CONCLUSION: QOL seems relatively well preserved in this cohort; only VR-QOL improved significantly at 6 months, especially in patients with low initial visual acuity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:105 |
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| Enthalten in: |
The British journal of ophthalmology - 105(2021), 7 vom: 24. Juli, Seite 935-940 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bertrand, Pierre-Jean [VerfasserIn] |
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| Links: |
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| Themen: |
Immunology |
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| Anmerkungen: |
Date Completed 24.09.2021 Date Revised 24.09.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1136/bjophthalmol-2020-315862 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM312857217 |
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| 100 | 1 | |a Bertrand, Pierre-Jean |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Quality of life in patients with uveitis |b data from the ULISSE study (Uveitis: cLInical and medico-economic evaluation of a Standardised Strategy for the Etiological diagnosis) |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a AIMS: To assess vision-related (VR-QOL) and health-related quality of life (HR-QOL) in a large series of patients with de novo uveitis at baseline and 6-month follow-up | ||
| 520 | |a METHODS: Non-inferiority, prospective, multicentre, cluster randomised controlled trial registered under the Unique Identifier: NCT01162070. VR-QOL and HR-QOL were assessed by the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) and the Medical Outcomes Study 36-item Short Form Survey (SF-36) | ||
| 520 | |a RESULTS: At inclusion, 466 patients completed the VFQ-25. The mean composite score was 80.0 (±16.7). In multivariate analysis, higher age, female sex and insidious onset were significantly associated with lower QOL. At 6 months, 138 patients completed the VFQ-25, with a significantly higher mean composite score of 82.6 (±16.7). SF-36 mental component was 42.9 (±11.3) and physical component was 47.2 (±8.5) at inclusion (n=425). HR-QOL improvement at 6 months was not clinically significant | ||
| 520 | |a CONCLUSION: QOL seems relatively well preserved in this cohort; only VR-QOL improved significantly at 6 months, especially in patients with low initial visual acuity | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Immunology | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Vision | |
| 700 | 1 | |a Jamilloux, Yvan |e verfasserin |4 aut | |
| 700 | 1 | |a Kodjikian, Laurent |e verfasserin |4 aut | |
| 700 | 1 | |a Errera, Marie-Helene |e verfasserin |4 aut | |
| 700 | 1 | |a Perard, Laurent |e verfasserin |4 aut | |
| 700 | 1 | |a Pugnet, Gregory |e verfasserin |4 aut | |
| 700 | 1 | |a Tieulie, Nathalie |e verfasserin |4 aut | |
| 700 | 1 | |a Andre, Marc |e verfasserin |4 aut | |
| 700 | 1 | |a Bielefeld, Philip |e verfasserin |4 aut | |
| 700 | 1 | |a Bron, Alain M |e verfasserin |4 aut | |
| 700 | 1 | |a Decullier, Evelyne |e verfasserin |4 aut | |
| 700 | 1 | |a Bin, Sylvie |e verfasserin |4 aut | |
| 700 | 1 | |a Seve, Pascal |e verfasserin |4 aut | |
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