Tracking Changes in SARS-CoV-2 Spike : Evidence that D614G Increases Infectivity of the COVID-19 Virus
Published by Elsevier Inc..
A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic. Dynamic tracking of variant frequencies revealed a recurrent pattern of G614 increase at multiple geographic levels: national, regional, and municipal. The shift occurred even in local epidemics where the original D614 form was well established prior to introduction of the G614 variant. The consistency of this pattern was highly statistically significant, suggesting that the G614 variant may have a fitness advantage. We found that the G614 variant grows to a higher titer as pseudotyped virions. In infected individuals, G614 is associated with lower RT-PCR cycle thresholds, suggestive of higher upper respiratory tract viral loads, but not with increased disease severity. These findings illuminate changes important for a mechanistic understanding of the virus and support continuing surveillance of Spike mutations to aid with development of immunological interventions.
| Errataetall: |
CommentIn: Cell. 2020 Aug 20;182(4):794-795. - PMID 32697970 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:182 |
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| Enthalten in: |
Cell - 182(2020), 4 vom: 20. Aug., Seite 812-827.e19 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Korber, Bette [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 26.08.2020 Date Revised 29.03.2024 published: Print-Electronic CommentIn: Cell. 2020 Aug 20;182(4):794-795. - PMID 32697970 Citation Status MEDLINE |
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| doi: |
10.1016/j.cell.2020.06.043 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM312740824 |
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| 245 | 1 | 0 | |a Tracking Changes in SARS-CoV-2 Spike |b Evidence that D614G Increases Infectivity of the COVID-19 Virus |
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| 500 | |a Date Completed 26.08.2020 | ||
| 500 | |a Date Revised 29.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Cell. 2020 Aug 20;182(4):794-795. - PMID 32697970 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Published by Elsevier Inc. | ||
| 520 | |a A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic. Dynamic tracking of variant frequencies revealed a recurrent pattern of G614 increase at multiple geographic levels: national, regional, and municipal. The shift occurred even in local epidemics where the original D614 form was well established prior to introduction of the G614 variant. The consistency of this pattern was highly statistically significant, suggesting that the G614 variant may have a fitness advantage. We found that the G614 variant grows to a higher titer as pseudotyped virions. In infected individuals, G614 is associated with lower RT-PCR cycle thresholds, suggestive of higher upper respiratory tract viral loads, but not with increased disease severity. These findings illuminate changes important for a mechanistic understanding of the virus and support continuing surveillance of Spike mutations to aid with development of immunological interventions | ||
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| 650 | 4 | |a antibody | |
| 650 | 4 | |a diversity | |
| 650 | 4 | |a evolution | |
| 650 | 4 | |a infectivity | |
| 650 | 4 | |a neutralization | |
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| 700 | 1 | |a Gnanakaran, Sandrasegaram |e verfasserin |4 aut | |
| 700 | 1 | |a Yoon, Hyejin |e verfasserin |4 aut | |
| 700 | 1 | |a Theiler, James |e verfasserin |4 aut | |
| 700 | 1 | |a Abfalterer, Werner |e verfasserin |4 aut | |
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| 700 | 1 | |a Bhattacharya, Tanmoy |e verfasserin |4 aut | |
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| 700 | 1 | |a Hastie, Kathryn M |e verfasserin |4 aut | |
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| 700 | 1 | |a de Silva, Thushan I |e verfasserin |4 aut | |
| 700 | 0 | |a Sheffield COVID-19 Genomics Group |e verfasserin |4 aut | |
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