Prospective Study in 355 Patients With Suspected COVID-19 Infection : Value of Cough, Subjective Hyposmia, and Hypogeusia
© 2020 American Laryngological, Rhinological and Otological Society Inc, The Triological Society and American Laryngological Association (ALA)..
OBJECTIVE: To evaluate the incidence of certain symptoms in a population of health workers exposed to coronavirus disease 2019 patients.
STUDY DESIGN: Case-control study.
METHODS: The study was conducted at a tertiary care hospital from March 1 to April 7, 2020. Health workers with suspected coronavirus disease 2019 (COVID-19) infection were included. The presence of COVID-19 was detected by using real-time polymerase chain reaction (RT-PCR) methods. Positive and negative RT-PCR patients were used as case and control groups, respectively. This study analyzed the incidence of COVID-19 symptoms in both patient groups. Visual analog scales were used for self-assessment of smell and taste disorders, ranging from 0 (no perception) to 10 (excellent perception).
RESULTS: There were 215 (60.6%) patients with positive RT-PCR and 140 (39.4%) patients with negative RT-PCR. The presence of symptoms such as hyposmia hypogeusia, dysthermia, and cough were strongly associated with a positive RT-PCR. The association of cough and subjective hyposmia had 5.46 times higher odds of having a positive test. The receiver operating characteristic (ROC) analysis showed that a fever higher than 37.45°C resulted in sensitivity and specificity of 0.65 and 0.61, respectively. A total of 138 cases (64.1%) and 114 cases (53%) had subjective hyposmia and hypogeusia, respectively. The 85.4% of these patients recovered olfactory function within the first 14 days of the onset of the symptoms.
CONCLUSION: There is a significant association between positive RT-PCR and subjective hyposmia. The association of subjective hyposmia and cough increase significantly the odds of having a positive RT-PCR. The measurement of fever as the only method for screening of COVID-19 infection resulted in a poor association.
LEVEL OF EVIDENCE: 3 Laryngoscope, 130:2674-2679, 2020.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:130 |
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| Enthalten in: |
The Laryngoscope - 130(2020), 11 vom: 19. Nov., Seite 2674-2679 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Martin-Sanz, Eduardo [VerfasserIn] |
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| Links: |
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| Themen: |
Hyposmia, hypogeusia, COVID-19, odds ratio, incidence, ROC |
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| Anmerkungen: |
Date Completed 21.12.2020 Date Revised 16.07.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/lary.28999 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM312625049 |
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| 100 | 1 | |a Martin-Sanz, Eduardo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prospective Study in 355 Patients With Suspected COVID-19 Infection |b Value of Cough, Subjective Hyposmia, and Hypogeusia |
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| 500 | |a Date Completed 21.12.2020 | ||
| 500 | |a Date Revised 16.07.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 American Laryngological, Rhinological and Otological Society Inc, The Triological Society and American Laryngological Association (ALA). | ||
| 520 | |a OBJECTIVE: To evaluate the incidence of certain symptoms in a population of health workers exposed to coronavirus disease 2019 patients | ||
| 520 | |a STUDY DESIGN: Case-control study | ||
| 520 | |a METHODS: The study was conducted at a tertiary care hospital from March 1 to April 7, 2020. Health workers with suspected coronavirus disease 2019 (COVID-19) infection were included. The presence of COVID-19 was detected by using real-time polymerase chain reaction (RT-PCR) methods. Positive and negative RT-PCR patients were used as case and control groups, respectively. This study analyzed the incidence of COVID-19 symptoms in both patient groups. Visual analog scales were used for self-assessment of smell and taste disorders, ranging from 0 (no perception) to 10 (excellent perception) | ||
| 520 | |a RESULTS: There were 215 (60.6%) patients with positive RT-PCR and 140 (39.4%) patients with negative RT-PCR. The presence of symptoms such as hyposmia hypogeusia, dysthermia, and cough were strongly associated with a positive RT-PCR. The association of cough and subjective hyposmia had 5.46 times higher odds of having a positive test. The receiver operating characteristic (ROC) analysis showed that a fever higher than 37.45°C resulted in sensitivity and specificity of 0.65 and 0.61, respectively. A total of 138 cases (64.1%) and 114 cases (53%) had subjective hyposmia and hypogeusia, respectively. The 85.4% of these patients recovered olfactory function within the first 14 days of the onset of the symptoms | ||
| 520 | |a CONCLUSION: There is a significant association between positive RT-PCR and subjective hyposmia. The association of subjective hyposmia and cough increase significantly the odds of having a positive RT-PCR. The measurement of fever as the only method for screening of COVID-19 infection resulted in a poor association | ||
| 520 | |a LEVEL OF EVIDENCE: 3 Laryngoscope, 130:2674-2679, 2020 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Hyposmia, hypogeusia, COVID-19, odds ratio, incidence, ROC | |
| 700 | 1 | |a Riestra, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Yebra, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Larran, Alba |e verfasserin |4 aut | |
| 700 | 1 | |a Mancino, Fiorella |e verfasserin |4 aut | |
| 700 | 1 | |a Yanes-Diaz, Joaquin |e verfasserin |4 aut | |
| 700 | 1 | |a Garrote, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Colmenero, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Montiel, Esther |e verfasserin |4 aut | |
| 700 | 1 | |a Molina, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Moreno, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Rodriguez, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Monedero, Gerardo |e verfasserin |4 aut | |
| 700 | 1 | |a Sanz-Fernández, Ricardo |e verfasserin |4 aut | |
| 700 | 1 | |a Gonzalez, Rocio |e verfasserin |4 aut | |
| 700 | 1 | |a Esteban-Sanchez, Jonathan |e verfasserin |4 aut | |
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