Different responses after intracerebral hemorrhage between young and early middle-aged mice
Copyright © 2020 Elsevier B.V. All rights reserved..
Although aging is a major risk factor for intracerebral hemorrhage (ICH), there are very few studies comparing ICH pathology between young and early middle-aged mice. In this study, 8-month old mice (early middle-aged mice) were compared against 2-month old mice (young mice) in neurological and histological changes after ICH induction, such as body weight, lesion volume, astrocytic responses, and motor and cognitive functions. At day 8 after ICH, there was no significant difference in lesion volume between the two groups, and both groups did not exhibit significant cognitive decline, as assessed by spontaneous alternative Y-maze test. On the other hand, 8-month old mice showed delayed recovery from body weight loss, along with reduced astrocytic activation. Interestingly, in the two motor function tests (beam-walking test and corner turn test), 8-month old mice exhibited lower scores only in the beam-walking test, suggesting a partial disturbance in motor recovery after ICH. These results suggest that age-related differences in ICH pathology may already start to appear in early middle-aged brains.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:735 |
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| Enthalten in: |
Neuroscience letters - 735(2020) vom: 14. Sept., Seite 135249 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kinoshita, Keita [VerfasserIn] |
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| Links: |
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| Themen: |
Astrocytes |
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| Anmerkungen: |
Date Completed 23.04.2021 Date Revised 15.09.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.neulet.2020.135249 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier B.V. All rights reserved. | ||
| 520 | |a Although aging is a major risk factor for intracerebral hemorrhage (ICH), there are very few studies comparing ICH pathology between young and early middle-aged mice. In this study, 8-month old mice (early middle-aged mice) were compared against 2-month old mice (young mice) in neurological and histological changes after ICH induction, such as body weight, lesion volume, astrocytic responses, and motor and cognitive functions. At day 8 after ICH, there was no significant difference in lesion volume between the two groups, and both groups did not exhibit significant cognitive decline, as assessed by spontaneous alternative Y-maze test. On the other hand, 8-month old mice showed delayed recovery from body weight loss, along with reduced astrocytic activation. Interestingly, in the two motor function tests (beam-walking test and corner turn test), 8-month old mice exhibited lower scores only in the beam-walking test, suggesting a partial disturbance in motor recovery after ICH. These results suggest that age-related differences in ICH pathology may already start to appear in early middle-aged brains | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Astrocytes | |
| 650 | 4 | |a Intracerebral hemorrhage | |
| 650 | 4 | |a Middle-aged mice | |
| 650 | 4 | |a Motor dysfunction | |
| 700 | 1 | |a Ohtomo, Ryo |e verfasserin |4 aut | |
| 700 | 1 | |a Takase, Hajime |e verfasserin |4 aut | |
| 700 | 1 | |a Hamanaka, Gen |e verfasserin |4 aut | |
| 700 | 1 | |a Chung, Kelly K |e verfasserin |4 aut | |
| 700 | 1 | |a Lok, Josephine |e verfasserin |4 aut | |
| 700 | 1 | |a Katsuki, Hiroshi |e verfasserin |4 aut | |
| 700 | 1 | |a Arai, Ken |e verfasserin |4 aut | |
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