Natural and synthetic coumarins as antileishmanial agents : A review

Copyright © 2020 Elsevier Masson SAS. All rights reserved..

The neglected tropical disease leishmaniasis is still a major public health problem that affects millions of people worldwide. Related to poor-living conditions, this vector-borne disease presents multiple clinical manifestations - from asymptomatic to systemic conditions. The protozoans of the genus Leishmania are the etiologic agents transmitted through the bite of sandflies, the main vectors. Current pharmacological interventions are outdated and present several drawbacks, thus the search for new antileishmanial compounds is imperative. Medicinal chemists have been continuously investigating for new alternatives to combat leishmaniasis, and coumarins play a pivotal role in this search. Various biological properties have been described owing to coumarin's structural versatility combined with its unique features, including antileishmanial activity. The aim of this review is to highlight the most relevant studies between 1997 and 2020 and provide a guide for the development of new antileishmanial coumarins. Naturally occurring and synthetically designed coumarins are comprised in this review, along with a structure-activity relationship to provide an insight for further development of coumarins with antileishmanial activity.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:203

Enthalten in:

European journal of medicinal chemistry - 203(2020) vom: 01. Okt., Seite 112514

Sprache:

Englisch

Beteiligte Personen:

Gonçalves, Guilherme Arraché [VerfasserIn]
Spillere, Adriano Ronchi [VerfasserIn]
das Neves, Gustavo Machado [VerfasserIn]
Kagami, Luciano Porto [VerfasserIn]
von Poser, Gilsane Lino [VerfasserIn]
Canto, Rômulo Faria Santos [VerfasserIn]
Eifler-Lima, VeraLucia [VerfasserIn]

Links:

Volltext

Themen:

Antileishmanial
Antiprotozoal Agents
Biological Products
Coumarin
Coumarins
Journal Article
Leishmaniasis
Review
Structure-activity relationship

Anmerkungen:

Date Completed 22.04.2021

Date Revised 22.04.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.ejmech.2020.112514

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM312447531