The molecular virology of coronaviruses
© 2020 Hartenian et al..
Few human pathogens have been the focus of as much concentrated worldwide attention as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its emergence into the human population and ensuing pandemic came on the heels of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), two other highly pathogenic coronavirus spillovers, which collectively have reshaped our view of a virus family previously associated primarily with the common cold. It has placed intense pressure on the collective scientific community to develop therapeutics and vaccines, whose engineering relies on a detailed understanding of coronavirus biology. Here, we present the molecular virology of coronavirus infection, including its entry into cells, its remarkably sophisticated gene expression and replication mechanisms, its extensive remodeling of the intracellular environment, and its multifaceted immune evasion strategies. We highlight aspects of the viral life cycle that may be amenable to antiviral targeting as well as key features of its biology that await discovery.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:295 |
|---|---|
| Enthalten in: |
The Journal of biological chemistry - 295(2020), 37 vom: 11. Sept., Seite 12910-12934 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hartenian, Ella [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 28.09.2020 Date Revised 04.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1074/jbc.REV120.013930 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM312378300 |
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| 500 | |a Date Revised 04.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
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| 520 | |a © 2020 Hartenian et al. | ||
| 520 | |a Few human pathogens have been the focus of as much concentrated worldwide attention as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its emergence into the human population and ensuing pandemic came on the heels of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), two other highly pathogenic coronavirus spillovers, which collectively have reshaped our view of a virus family previously associated primarily with the common cold. It has placed intense pressure on the collective scientific community to develop therapeutics and vaccines, whose engineering relies on a detailed understanding of coronavirus biology. Here, we present the molecular virology of coronavirus infection, including its entry into cells, its remarkably sophisticated gene expression and replication mechanisms, its extensive remodeling of the intracellular environment, and its multifaceted immune evasion strategies. We highlight aspects of the viral life cycle that may be amenable to antiviral targeting as well as key features of its biology that await discovery | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a RNA polymerase | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a cellular immune response | |
| 650 | 4 | |a coronavirus | |
| 650 | 4 | |a endoplasmic reticulum | |
| 650 | 4 | |a endoplasmic reticulum (ER) | |
| 650 | 4 | |a innate immunity | |
| 650 | 4 | |a pathogenesis | |
| 650 | 4 | |a plus-stranded RNA virus | |
| 650 | 4 | |a viral replication | |
| 650 | 4 | |a virology | |
| 650 | 4 | |a virus | |
| 650 | 4 | |a virus entry | |
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| 700 | 1 | |a Nandakumar, Divya |e verfasserin |4 aut | |
| 700 | 1 | |a Lari, Azra |e verfasserin |4 aut | |
| 700 | 1 | |a Ly, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Tucker, Jessica M |e verfasserin |4 aut | |
| 700 | 1 | |a Glaunsinger, Britt A |e verfasserin |4 aut | |
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