A Retrospective Cohort Study of Histology-Proven Neuroendocrine Neoplasms in the Italian Area of Udine
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
AIMS: The aim of this study was to investigate the epidemiology of histology-proven Neuroendocrine neoplasms (NENs) in an Italian area.
BACKGROUND: NENs are a rare and poorly known disease and the global incidence and prevalence appear to be increasing over the past decades.
OBJECTIVE: The objectives of this study were to estimate the incidence and trends of NENs in a 250,000-inhabitant area in the North-East of Italy in the 1998-2018 period and to compare them with international data.
METHODS: This retrospective cohort study was based on the analysis of anonymous health administrative databases, linked with each other at individual patient level through an anonymous stochastic key. NENs were identified from the anatomical pathology database. The standardized incidence rate (2010ESP and US2000) ± 95% CI per 100,000 were calculated, both annually and globally, for the whole period. Incidence was also calculated for specific anatomical sites and by gender. Trends for the considered periods and sites were summarized through the annual percent change (APC) and average increase (cases per 100,000 per year).
RESULTS: In the 1998-2018 period, the standardized incidence rate of NENs in the area of Udine was 2.49 (APC 3.33). A total of 162 cases were observed (51.2% males). Differences in incidence and trend were observed between sexes. The obtained results were consistent with those reported in other countries, confirming a significant and steady increase in NENs incidence in the last twenty years.
CONCLUSION: This study provides new epidemiological data on NENs in Italy. The observed sex differences deserve further investigations.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
|---|---|
| Enthalten in: |
Endocrine, metabolic & immune disorders drug targets - 21(2021), 3 vom: 08., Seite 448-457 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Valent, Francesca [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Comparative Study |
|---|
| Anmerkungen: |
Date Completed 08.11.2021 Date Revised 08.11.2021 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.2174/1871530320666200713093533 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM312370504 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM312370504 | ||
| 003 | DE-627 | ||
| 005 | 20231225144255.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2174/1871530320666200713093533 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1041.xml |
| 035 | |a (DE-627)NLM312370504 | ||
| 035 | |a (NLM)32660412 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Valent, Francesca |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A Retrospective Cohort Study of Histology-Proven Neuroendocrine Neoplasms in the Italian Area of Udine |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 08.11.2021 | ||
| 500 | |a Date Revised 08.11.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a AIMS: The aim of this study was to investigate the epidemiology of histology-proven Neuroendocrine neoplasms (NENs) in an Italian area | ||
| 520 | |a BACKGROUND: NENs are a rare and poorly known disease and the global incidence and prevalence appear to be increasing over the past decades | ||
| 520 | |a OBJECTIVE: The objectives of this study were to estimate the incidence and trends of NENs in a 250,000-inhabitant area in the North-East of Italy in the 1998-2018 period and to compare them with international data | ||
| 520 | |a METHODS: This retrospective cohort study was based on the analysis of anonymous health administrative databases, linked with each other at individual patient level through an anonymous stochastic key. NENs were identified from the anatomical pathology database. The standardized incidence rate (2010ESP and US2000) ± 95% CI per 100,000 were calculated, both annually and globally, for the whole period. Incidence was also calculated for specific anatomical sites and by gender. Trends for the considered periods and sites were summarized through the annual percent change (APC) and average increase (cases per 100,000 per year) | ||
| 520 | |a RESULTS: In the 1998-2018 period, the standardized incidence rate of NENs in the area of Udine was 2.49 (APC 3.33). A total of 162 cases were observed (51.2% males). Differences in incidence and trend were observed between sexes. The obtained results were consistent with those reported in other countries, confirming a significant and steady increase in NENs incidence in the last twenty years | ||
| 520 | |a CONCLUSION: This study provides new epidemiological data on NENs in Italy. The observed sex differences deserve further investigations | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Italy | |
| 650 | 4 | |a Neuroendocrine tumors | |
| 650 | 4 | |a epidemiology | |
| 650 | 4 | |a incidence | |
| 650 | 4 | |a rare tumors | |
| 650 | 4 | |a tumors | |
| 700 | 1 | |a Tullio, Annarita |e verfasserin |4 aut | |
| 700 | 1 | |a Kara, Elda |e verfasserin |4 aut | |
| 700 | 1 | |a Cipri, Claudia |e verfasserin |4 aut | |
| 700 | 1 | |a Sciannimanico, Silvia M |e verfasserin |4 aut | |
| 700 | 1 | |a Vescini, Fabio |e verfasserin |4 aut | |
| 700 | 1 | |a Grimaldi, Franco |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Endocrine, metabolic & immune disorders drug targets |d 2006 |g 21(2021), 3 vom: 08., Seite 448-457 |w (DE-627)NLM161976174 |x 2212-3873 |7 nnns |
| 773 | 1 | 8 | |g volume:21 |g year:2021 |g number:3 |g day:08 |g pages:448-457 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2174/1871530320666200713093533 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 21 |j 2021 |e 3 |b 08 |h 448-457 | ||