Clinical characteristics and outcomes of COVID-19 in solid organ transplant recipients : A cohort study
© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons..
Solid organ transplant recipients (SOTr) with coronavirus disease 2019 (COVID-19) are expected to have poorer outcomes compared to nontransplant patients because of immunosuppression and comorbidities. The clinical characteristics of 47 SOTr (38 kidneys and 9 nonkidney organs) were compared to 100 consecutive hospitalized nontransplant controls. Twelve of 47 SOTr managed as outpatients were subsequently excluded from the outcome analyses to avoid potential selection bias. Chronic kidney disease (89% vs 57% P = .0007), diabetes (66% vs 33% P = .0007), and hypertension (94% vs 72% P = .006) were more common in the 35 hospitalized SOTr compared to controls. Diarrhea (54% vs 17%, P < .0001) was more frequent in SOTr. Primary composite outcome (escalation to intensive care unit, mechanical ventilation, or in-hospital all-cause mortality) was comparable between SOTr and controls (40% vs 48%, odds ratio [OR] 0.72 confidence interval [CI] [0.33-1.58] P = .42), despite more comorbidities in SOTr. Acute kidney injury requiring renal replacement therapy occurred in 20% of SOTr compared to 4% of controls (OR 6 CI [1.64-22] P = .007). Multivariate analysis demonstrated that increasing age and clinical severity were associated with mortality. Transplant status itself was not associated with mortality.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
|---|---|
| Enthalten in: |
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 20(2020), 11 vom: Nov., Seite 3051-3060 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Chaudhry, Zohra S [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 23.12.2020 Date Revised 09.02.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1111/ajt.16188 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM312310382 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM312310382 | ||
| 003 | DE-627 | ||
| 005 | 20231225144137.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/ajt.16188 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1041.xml |
| 035 | |a (DE-627)NLM312310382 | ||
| 035 | |a (NLM)32654332 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Chaudhry, Zohra S |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical characteristics and outcomes of COVID-19 in solid organ transplant recipients |b A cohort study |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 23.12.2020 | ||
| 500 | |a Date Revised 09.02.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 The American Society of Transplantation and the American Society of Transplant Surgeons. | ||
| 520 | |a Solid organ transplant recipients (SOTr) with coronavirus disease 2019 (COVID-19) are expected to have poorer outcomes compared to nontransplant patients because of immunosuppression and comorbidities. The clinical characteristics of 47 SOTr (38 kidneys and 9 nonkidney organs) were compared to 100 consecutive hospitalized nontransplant controls. Twelve of 47 SOTr managed as outpatients were subsequently excluded from the outcome analyses to avoid potential selection bias. Chronic kidney disease (89% vs 57% P = .0007), diabetes (66% vs 33% P = .0007), and hypertension (94% vs 72% P = .006) were more common in the 35 hospitalized SOTr compared to controls. Diarrhea (54% vs 17%, P < .0001) was more frequent in SOTr. Primary composite outcome (escalation to intensive care unit, mechanical ventilation, or in-hospital all-cause mortality) was comparable between SOTr and controls (40% vs 48%, odds ratio [OR] 0.72 confidence interval [CI] [0.33-1.58] P = .42), despite more comorbidities in SOTr. Acute kidney injury requiring renal replacement therapy occurred in 20% of SOTr compared to 4% of controls (OR 6 CI [1.64-22] P = .007). Multivariate analysis demonstrated that increasing age and clinical severity were associated with mortality. Transplant status itself was not associated with mortality | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a clinical research/practice | |
| 650 | 4 | |a complication: infectious | |
| 650 | 4 | |a infection and infectious agents - viral | |
| 650 | 4 | |a infectious disease | |
| 650 | 4 | |a kidney transplantation/nephrology | |
| 650 | 4 | |a organ transplantation in general | |
| 700 | 1 | |a Williams, Jonathan D |e verfasserin |4 aut | |
| 700 | 1 | |a Vahia, Amit |e verfasserin |4 aut | |
| 700 | 1 | |a Fadel, Raef |e verfasserin |4 aut | |
| 700 | 1 | |a Parraga Acosta, Tommy |e verfasserin |4 aut | |
| 700 | 1 | |a Prashar, Rohini |e verfasserin |4 aut | |
| 700 | 1 | |a Shrivastava, Pritika |e verfasserin |4 aut | |
| 700 | 1 | |a Khoury, Nadeen |e verfasserin |4 aut | |
| 700 | 1 | |a Pinto Corrales, Julio |e verfasserin |4 aut | |
| 700 | 1 | |a Williams, Celeste |e verfasserin |4 aut | |
| 700 | 1 | |a Nagai, Shunji |e verfasserin |4 aut | |
| 700 | 1 | |a Abouljoud, Marwan |e verfasserin |4 aut | |
| 700 | 1 | |a Samaniego-Picota, Milagros |e verfasserin |4 aut | |
| 700 | 1 | |a Abreu-Lanfranco, Odaliz |e verfasserin |4 aut | |
| 700 | 1 | |a Del Busto, Ramon |e verfasserin |4 aut | |
| 700 | 1 | |a Ramesh, Mayur S |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Anita |e verfasserin |4 aut | |
| 700 | 1 | |a Alangaden, George J |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons |d 2001 |g 20(2020), 11 vom: Nov., Seite 3051-3060 |w (DE-627)NLM119667924 |x 1600-6143 |7 nnns |
| 773 | 1 | 8 | |g volume:20 |g year:2020 |g number:11 |g month:11 |g pages:3051-3060 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1111/ajt.16188 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 20 |j 2020 |e 11 |c 11 |h 3051-3060 | ||