Risk Factors for Healthcare Personnel Infection With Endemic Coronaviruses (HKU1, OC43, NL63, 229E) : Results from the Respiratory Protection Effectiveness Clinical Trial (ResPECT)
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissionsoup.com..
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents a large risk to healthcare personnel (HCP). Quantifying the risk of coronavirus infection associated with workplace activities is an urgent need.
METHODS: We assessed the association of worker characteristics, occupational roles and behaviors, and participation in procedures with the risk of endemic coronavirus infection among HCP who participated in the Respiratory Protection Effectiveness Clinical Trial (ResPECT), a cluster randomized trial to assess personal protective equipment to prevent respiratory infections and illness conducted from 2011 to 2016.
RESULTS: Among 4689 HCP seasons, we detected coronavirus infection in 387 (8%). HCP who participated in an aerosol-generating procedure (AGP) at least once during the viral respiratory season were 105% (95% confidence interval, 21%-240%) more likely to be diagnosed with a laboratory-confirmed coronavirus infection. Younger individuals, those who saw pediatric patients, and those with household members <5 years of age were at increased risk of coronavirus infection.
CONCLUSIONS: Our analysis suggests that the risk of HCP becoming infected with an endemic coronavirus increases approximately 2-fold with exposures to AGPs. Our findings may be relevant to the coronavirus disease 2019 (COVID-19) pandemic; however, SARS-CoV-2, the virus that causes COVID-19, may differ from endemic coronaviruses in important ways.
CLINICAL TRIALS REGISTRATION: NCT01249625.
| Errataetall: |
CommentIn: Sultan Qaboos Univ Med J. 2021 Feb;21(1):e1-e3. - PMID 33777417 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:73 |
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| Enthalten in: |
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 73(2021), 11 vom: 06. Dez., Seite e4428-e4432 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cummings, Derek A T [VerfasserIn] |
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| Links: |
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| Themen: |
229E |
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| Anmerkungen: |
Date Completed 13.12.2021 Date Revised 14.12.2021 published: Print ClinicalTrials.gov: NCT01249625 CommentIn: Sultan Qaboos Univ Med J. 2021 Feb;21(1):e1-e3. - PMID 33777417 Citation Status MEDLINE |
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| doi: |
10.1093/cid/ciaa900 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM312219490 |
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| 245 | 1 | 0 | |a Risk Factors for Healthcare Personnel Infection With Endemic Coronaviruses (HKU1, OC43, NL63, 229E) |b Results from the Respiratory Protection Effectiveness Clinical Trial (ResPECT) |
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| 500 | |a Date Revised 14.12.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a ClinicalTrials.gov: NCT01249625 | ||
| 500 | |a CommentIn: Sultan Qaboos Univ Med J. 2021 Feb;21(1):e1-e3. - PMID 33777417 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissionsoup.com. | ||
| 520 | |a BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents a large risk to healthcare personnel (HCP). Quantifying the risk of coronavirus infection associated with workplace activities is an urgent need | ||
| 520 | |a METHODS: We assessed the association of worker characteristics, occupational roles and behaviors, and participation in procedures with the risk of endemic coronavirus infection among HCP who participated in the Respiratory Protection Effectiveness Clinical Trial (ResPECT), a cluster randomized trial to assess personal protective equipment to prevent respiratory infections and illness conducted from 2011 to 2016 | ||
| 520 | |a RESULTS: Among 4689 HCP seasons, we detected coronavirus infection in 387 (8%). HCP who participated in an aerosol-generating procedure (AGP) at least once during the viral respiratory season were 105% (95% confidence interval, 21%-240%) more likely to be diagnosed with a laboratory-confirmed coronavirus infection. Younger individuals, those who saw pediatric patients, and those with household members <5 years of age were at increased risk of coronavirus infection | ||
| 520 | |a CONCLUSIONS: Our analysis suggests that the risk of HCP becoming infected with an endemic coronavirus increases approximately 2-fold with exposures to AGPs. Our findings may be relevant to the coronavirus disease 2019 (COVID-19) pandemic; however, SARS-CoV-2, the virus that causes COVID-19, may differ from endemic coronaviruses in important ways | ||
| 520 | |a CLINICAL TRIALS REGISTRATION: NCT01249625 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a 229E | |
| 650 | 4 | |a Coronavirus | |
| 650 | 4 | |a HKU1 | |
| 650 | 4 | |a NL63 | |
| 650 | 4 | |a OC43 | |
| 650 | 4 | |a aerosol generating procedure | |
| 650 | 4 | |a risk factors | |
| 700 | 1 | |a Radonovich, Lewis J |e verfasserin |4 aut | |
| 700 | 1 | |a Gorse, Geoffrey J |e verfasserin |4 aut | |
| 700 | 1 | |a Gaydos, Charlotte A |e verfasserin |4 aut | |
| 700 | 1 | |a Bessesen, Mary T |e verfasserin |4 aut | |
| 700 | 1 | |a Brown, Alexandria C |e verfasserin |4 aut | |
| 700 | 1 | |a Gibert, Cynthia L |e verfasserin |4 aut | |
| 700 | 1 | |a Hitchings, Matthew D T |e verfasserin |4 aut | |
| 700 | 1 | |a Lessler, Justin |e verfasserin |4 aut | |
| 700 | 1 | |a Nyquist, Ann-Christine |e verfasserin |4 aut | |
| 700 | 1 | |a Rattigan, Susan M |e verfasserin |4 aut | |
| 700 | 1 | |a Rodriguez-Barradas, Maria C |e verfasserin |4 aut | |
| 700 | 1 | |a Price, Connie Savor |e verfasserin |4 aut | |
| 700 | 1 | |a Reich, Nicholas G |e verfasserin |4 aut | |
| 700 | 1 | |a Simberkoff, Michael S |e verfasserin |4 aut | |
| 700 | 1 | |a Perl, Trish M |e verfasserin |4 aut | |
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