CuH-Catalyzed Asymmetric Reductive Amidation of α,β-Unsaturated Carboxylic Acids

The direct enantioselective copper hydride (CuH)-catalyzed synthesis of β-chiral amides from α,β-unsaturated carboxylic acids and secondary amines under mild reaction conditions is reported. The method utilizes readily accessible carboxylic acids and tolerates a variety of functional groups in the β-position including several heteroarenes. A subsequent iridium-catalyzed reduction to γ-chiral amines can be performed in the same flask without purification of the intermediate amides.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:22

Enthalten in:

Organic letters - 22(2020), 14 vom: 17. Juli, Seite 5666-5670

Sprache:

Englisch

Beteiligte Personen:

Link, Achim [VerfasserIn]
Zhou, Yujing [VerfasserIn]
Buchwald, Stephen L [VerfasserIn]

Links:

Volltext

Themen:

44448S9773
Amides
Amines
Carboxylic Acids
Iridium
Journal Article
Research Support, N.I.H., Extramural

Anmerkungen:

Date Completed 02.07.2021

Date Revised 18.07.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1021/acs.orglett.0c02064

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM312057156