CuH-Catalyzed Asymmetric Reductive Amidation of α,β-Unsaturated Carboxylic Acids
The direct enantioselective copper hydride (CuH)-catalyzed synthesis of β-chiral amides from α,β-unsaturated carboxylic acids and secondary amines under mild reaction conditions is reported. The method utilizes readily accessible carboxylic acids and tolerates a variety of functional groups in the β-position including several heteroarenes. A subsequent iridium-catalyzed reduction to γ-chiral amines can be performed in the same flask without purification of the intermediate amides.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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Enthalten in: |
Organic letters - 22(2020), 14 vom: 17. Juli, Seite 5666-5670 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Link, Achim [VerfasserIn] |
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Links: |
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Themen: |
44448S9773 |
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Anmerkungen: |
Date Completed 02.07.2021 Date Revised 18.07.2021 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1021/acs.orglett.0c02064 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM312057156 |
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520 | |a The direct enantioselective copper hydride (CuH)-catalyzed synthesis of β-chiral amides from α,β-unsaturated carboxylic acids and secondary amines under mild reaction conditions is reported. The method utilizes readily accessible carboxylic acids and tolerates a variety of functional groups in the β-position including several heteroarenes. A subsequent iridium-catalyzed reduction to γ-chiral amines can be performed in the same flask without purification of the intermediate amides | ||
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