Neurosensory dysfunction : A diagnostic marker of early COVID-19
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved..
OBJECTIVE: To describe neurosensory dysfunctions, including hyposmia, hypogeusia, and tinnitus, in patients with COVID-19.
METHODS: Clinical characteristics and oropharyngeal swabs were obtained from 86 patients with COVID-19 hospitalized in Guangzhou Eighth People's Hospital. The chronological analysis method was used to detail neurosensory dysfunction. The cycle threshold (Ct) values were used to approximately indicate viral load.
RESULTS: Forty-four (51.2%) patients had neurosensory dysfunction: hyposmia (34, 39.5%), hypogeusia (33, 38.4%), and tinnitus (three, 3.5%). Neurosensory dysfunction was significantly more common in patients under 40 years old (p = 0.001) and women (p = 0.006). Hyposmia and hypogeusia coexisted in 23 (26.7%) patients. The interval between onset of hyposmia and hypogeusia was 0.7 ± 1.46 days. The interval from onset of hyposmia and hypogeusia to typical COVID-19 symptoms was 0.22 ± 4.57 and 0.75 ± 6.77 days; the interval from onset of hyposmia and hypogeusia to admission was 6.06 ± 6.68 and 5.76 ± 7.68 days; and the duration of hyposmia and hypogeusia was 9.09 ± 5.74 and 7.12 ± 4.66 days, respectively. The viral load was high following symptoms onset, peaked within the first week, and gradually declined.
CONCLUSIONS: Neurosensory dysfunction tends to occur in the early stage of COVID-19, and it could be used as a marker for the early diagnosis of COVID-19.
| Errataetall: |
CommentIn: Int J Infect Dis. 2020 Oct;99:8-9. - PMID 32707088 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:98 |
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| Enthalten in: |
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 98(2020) vom: 19. Sept., Seite 347-352 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liang, Yujie [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 21.09.2020 Date Revised 10.01.2021 published: Print-Electronic CommentIn: Int J Infect Dis. 2020 Oct;99:8-9. - PMID 32707088 Citation Status MEDLINE |
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| doi: |
10.1016/j.ijid.2020.06.086 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM31193126X |
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| 245 | 1 | 0 | |a Neurosensory dysfunction |b A diagnostic marker of early COVID-19 |
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| 500 | |a CommentIn: Int J Infect Dis. 2020 Oct;99:8-9. - PMID 32707088 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a OBJECTIVE: To describe neurosensory dysfunctions, including hyposmia, hypogeusia, and tinnitus, in patients with COVID-19 | ||
| 520 | |a METHODS: Clinical characteristics and oropharyngeal swabs were obtained from 86 patients with COVID-19 hospitalized in Guangzhou Eighth People's Hospital. The chronological analysis method was used to detail neurosensory dysfunction. The cycle threshold (Ct) values were used to approximately indicate viral load | ||
| 520 | |a RESULTS: Forty-four (51.2%) patients had neurosensory dysfunction: hyposmia (34, 39.5%), hypogeusia (33, 38.4%), and tinnitus (three, 3.5%). Neurosensory dysfunction was significantly more common in patients under 40 years old (p = 0.001) and women (p = 0.006). Hyposmia and hypogeusia coexisted in 23 (26.7%) patients. The interval between onset of hyposmia and hypogeusia was 0.7 ± 1.46 days. The interval from onset of hyposmia and hypogeusia to typical COVID-19 symptoms was 0.22 ± 4.57 and 0.75 ± 6.77 days; the interval from onset of hyposmia and hypogeusia to admission was 6.06 ± 6.68 and 5.76 ± 7.68 days; and the duration of hyposmia and hypogeusia was 9.09 ± 5.74 and 7.12 ± 4.66 days, respectively. The viral load was high following symptoms onset, peaked within the first week, and gradually declined | ||
| 520 | |a CONCLUSIONS: Neurosensory dysfunction tends to occur in the early stage of COVID-19, and it could be used as a marker for the early diagnosis of COVID-19 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Diagnosis | |
| 650 | 4 | |a Hypogeusia | |
| 650 | 4 | |a Hyposmia | |
| 650 | 4 | |a Neurosensory dysfunction | |
| 700 | 1 | |a Xu, Jiabin |e verfasserin |4 aut | |
| 700 | 1 | |a Chu, Mei |e verfasserin |4 aut | |
| 700 | 1 | |a Mai, Jianbo |e verfasserin |4 aut | |
| 700 | 1 | |a Lai, Niangmei |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Wen |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Tuanjie |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Sien |e verfasserin |4 aut | |
| 700 | 1 | |a Guan, Chenyu |e verfasserin |4 aut | |
| 700 | 1 | |a Zhong, Fan |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Liuping |e verfasserin |4 aut | |
| 700 | 1 | |a Liao, Guiqing |e verfasserin |4 aut | |
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