SARS-CoV-2 detection, viral load and infectivity over the course of an infection
Copyright © 2020. Published by Elsevier Ltd..
OBJECTIVES: To summarise the evidence on the detection pattern and viral load of SARS-CoV-2 over the course of an infection (including any asymptomatic or pre-symptomatic phase), and the duration of infectivity.
METHODS: A systematic literature search was undertaken in PubMed, Europe PubMed Central and EMBASE from 30 December 2019 to 12 May 2020.
RESULTS: We identified 113 studies conducted in 17 countries. The evidence from upper respiratory tract samples suggests that the viral load of SARS-CoV-2 peaks around symptom onset or a few days thereafter, and becomes undetectable about two weeks after symptom onset; however, viral loads from sputum samples may be higher, peak later and persist for longer. There is evidence of prolonged virus detection in stool samples, with unclear clinical significance. No study was found that definitively measured the duration of infectivity; however, patients may not be infectious for the entire duration of virus detection, as the presence of viral ribonucleic acid may not represent transmissible live virus.
CONCLUSION: There is a relatively consistent trajectory of SARS-CoV-2 viral load over the course of COVID-19 from respiratory tract samples, however the duration of infectivity remains uncertain.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:81 |
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| Enthalten in: |
The Journal of infection - 81(2020), 3 vom: 01. Sept., Seite 357-371 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Walsh, Kieran A [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 28.08.2020 Date Revised 11.11.2023 published: Print-Electronic CommentIn: J Infect. 2020 Dec;81(6):e1-e3. - PMID 32853596 Citation Status MEDLINE |
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| doi: |
10.1016/j.jinf.2020.06.067 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM311929990 |
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| 100 | 1 | |a Walsh, Kieran A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a SARS-CoV-2 detection, viral load and infectivity over the course of an infection |
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| 500 | |a Date Completed 28.08.2020 | ||
| 500 | |a Date Revised 11.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: J Infect. 2020 Dec;81(6):e1-e3. - PMID 32853596 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020. Published by Elsevier Ltd. | ||
| 520 | |a OBJECTIVES: To summarise the evidence on the detection pattern and viral load of SARS-CoV-2 over the course of an infection (including any asymptomatic or pre-symptomatic phase), and the duration of infectivity | ||
| 520 | |a METHODS: A systematic literature search was undertaken in PubMed, Europe PubMed Central and EMBASE from 30 December 2019 to 12 May 2020 | ||
| 520 | |a RESULTS: We identified 113 studies conducted in 17 countries. The evidence from upper respiratory tract samples suggests that the viral load of SARS-CoV-2 peaks around symptom onset or a few days thereafter, and becomes undetectable about two weeks after symptom onset; however, viral loads from sputum samples may be higher, peak later and persist for longer. There is evidence of prolonged virus detection in stool samples, with unclear clinical significance. No study was found that definitively measured the duration of infectivity; however, patients may not be infectious for the entire duration of virus detection, as the presence of viral ribonucleic acid may not represent transmissible live virus | ||
| 520 | |a CONCLUSION: There is a relatively consistent trajectory of SARS-CoV-2 viral load over the course of COVID-19 from respiratory tract samples, however the duration of infectivity remains uncertain | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Coronavirus | |
| 650 | 4 | |a Infectivity | |
| 650 | 4 | |a RNA | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a Viral load | |
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| 700 | 1 | |a Jordan, Karen |e verfasserin |4 aut | |
| 700 | 1 | |a Clyne, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Rohde, Daniela |e verfasserin |4 aut | |
| 700 | 1 | |a Drummond, Linda |e verfasserin |4 aut | |
| 700 | 1 | |a Byrne, Paula |e verfasserin |4 aut | |
| 700 | 1 | |a Ahern, Susan |e verfasserin |4 aut | |
| 700 | 1 | |a Carty, Paul G |e verfasserin |4 aut | |
| 700 | 1 | |a O'Brien, Kirsty K |e verfasserin |4 aut | |
| 700 | 1 | |a O'Murchu, Eamon |e verfasserin |4 aut | |
| 700 | 1 | |a O'Neill, Michelle |e verfasserin |4 aut | |
| 700 | 1 | |a Smith, Susan M |e verfasserin |4 aut | |
| 700 | 1 | |a Ryan, Máirín |e verfasserin |4 aut | |
| 700 | 1 | |a Harrington, Patricia |e verfasserin |4 aut | |
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