The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019 : A Retrospective Cohort Study
Copyright © 2020 Korean Diabetes Association..
BACKGROUND: To determine the role of diabetes mellitus (DM) in the coronavirus disease 2019 (COVID-19), we explored the clinical characteristics of patients with DM and compared risk factors such as age, glycemic control, and medications to those without DM.
METHODS: This was a retrospective cohort study of 117 confirmed patients with COVID-19 which conducted at a tertiary hospital in Daegu, South Korea. The primary outcome was defined as the severe and critical outcome (SCO), of which the composite outcomes of acute respiratory distress syndrome, septic shock, intensive care unit care, and 28-day mortality. We analyzed what clinical features and glycemic control-related factors affect the prognosis of COVID-19 in the DM group.
RESULTS: After exclusion, 110 participants were finally included. DM patients (n=29) was older, and showed higher blood pressure compared to non-DM patients. DM group showed higher levels of inflammation-related biomarkers and severity score, and highly progressed to SCO. After adjustment with other risk factors, DM increased the risk of SCO (odds ratio [OR], 10.771; P<0.001). Among the DM patients, SCO was more prevalent in elderly patients of ≥70 years old and age was an independent risk factor for SCO in patients with DM (OR, 1.175; P=0.014), while glycemic control was not. The use of medication did not affect the SCO, but the renin-angiotensin system inhibitors showed protective effects against acute cardiac injury (OR, 0.048; P=0.045).
CONCLUSION: The COVID-19 patients with DM had higher severity and resulted in SCO. Intensive and aggressive monitoring of COVID-19 clinical outcomes in DM group, especially in elderly patients is warranted.
| Errataetall: |
CommentIn: Diabetes Metab J. 2020 Aug;44(4):621-622. - PMID 32856803 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:44 |
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| Enthalten in: |
Diabetes & metabolism journal - 44(2020), 3 vom: 01. Juni, Seite 405-413 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chung, Seung Min [VerfasserIn] |
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| Links: |
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| Themen: |
Aged |
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| Anmerkungen: |
Date Completed 09.07.2020 Date Revised 18.12.2020 published: Print-Electronic CommentIn: Diabetes Metab J. 2020 Aug;44(4):621-622. - PMID 32856803 Citation Status MEDLINE |
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| doi: |
10.4093/dmj.2020.0105 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM311803237 |
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| 245 | 1 | 4 | |a The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019 |b A Retrospective Cohort Study |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Revised 18.12.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Diabetes Metab J. 2020 Aug;44(4):621-622. - PMID 32856803 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Korean Diabetes Association. | ||
| 520 | |a BACKGROUND: To determine the role of diabetes mellitus (DM) in the coronavirus disease 2019 (COVID-19), we explored the clinical characteristics of patients with DM and compared risk factors such as age, glycemic control, and medications to those without DM | ||
| 520 | |a METHODS: This was a retrospective cohort study of 117 confirmed patients with COVID-19 which conducted at a tertiary hospital in Daegu, South Korea. The primary outcome was defined as the severe and critical outcome (SCO), of which the composite outcomes of acute respiratory distress syndrome, septic shock, intensive care unit care, and 28-day mortality. We analyzed what clinical features and glycemic control-related factors affect the prognosis of COVID-19 in the DM group | ||
| 520 | |a RESULTS: After exclusion, 110 participants were finally included. DM patients (n=29) was older, and showed higher blood pressure compared to non-DM patients. DM group showed higher levels of inflammation-related biomarkers and severity score, and highly progressed to SCO. After adjustment with other risk factors, DM increased the risk of SCO (odds ratio [OR], 10.771; P<0.001). Among the DM patients, SCO was more prevalent in elderly patients of ≥70 years old and age was an independent risk factor for SCO in patients with DM (OR, 1.175; P=0.014), while glycemic control was not. The use of medication did not affect the SCO, but the renin-angiotensin system inhibitors showed protective effects against acute cardiac injury (OR, 0.048; P=0.045) | ||
| 520 | |a CONCLUSION: The COVID-19 patients with DM had higher severity and resulted in SCO. Intensive and aggressive monitoring of COVID-19 clinical outcomes in DM group, especially in elderly patients is warranted | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Aged | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Diabetes mellitus | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Risk factors | |
| 650 | 4 | |a Severe acute respiratory syndrome coronavirus 2 | |
| 700 | 1 | |a Lee, Yin Young |e verfasserin |4 aut | |
| 700 | 1 | |a Ha, Eunyeong |e verfasserin |4 aut | |
| 700 | 1 | |a Yoon, Ji Sung |e verfasserin |4 aut | |
| 700 | 1 | |a Won, Kyu Chang |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Hyoung Woo |e verfasserin |4 aut | |
| 700 | 1 | |a Hur, Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Hong, Kyung Soo |e verfasserin |4 aut | |
| 700 | 1 | |a Jang, Jong Geol |e verfasserin |4 aut | |
| 700 | 1 | |a Jin, Hyun Jung |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Eun Young |e verfasserin |4 aut | |
| 700 | 1 | |a Shin, Kyeong Cheol |e verfasserin |4 aut | |
| 700 | 1 | |a Chung, Jin Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Kwan Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Ahn, June Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Moon, Jun Sung |e verfasserin |4 aut | |
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