Olfactory and Gustatory Outcomes in COVID-19 : A Prospective Evaluation in Nonhospitalized Subjects
OBJECTIVE: To prospectively assess the rate and timing of recovery of olfactory (OD) and gustatory (GD) dysfunction in patients affected by COVID-19.
STUDY DESIGN: Cohort study.
SETTING: Population-based evaluation in a COVID-19 high-prevalence region.
SUBJECTS AND METHODS: We analyzed the clinical course of OD and GD in a cohort of home-quarantined SARS-CoV-2-positive patients from Northern Italy. Physicians administered a survey-based questionnaire at recruitment (T0). During follow-up, patients responded to online dedicated surveys modulated according to symptoms at T0.
RESULTS: A total of 151 patients completed the follow-up survey. OD and/or GD were observed in 83% and 89% of subjects, respectively. Resolution rates of OD and GD at 30 days from onset were 87% and 82%, respectively. Risk factors for late resolution were grade of dysfunction at onset (total vs partial), gender, and presence of nasal congestion. Three (2%) patients previously reporting complete resolution of symptoms complained of subsequent recurrence of OD and/or GD after a mean of 19 days from resolution of the previous episode.
CONCLUSION: COVID-19-related OD and GD had high rate of resolution in the first month from onset of symptoms. However, in 10% to 15% of patients, these symptoms showed only partial improvement after this period.
| Errataetall: |
CommentIn: Otolaryngol Head Neck Surg. 2021 Nov;165(5):755. - PMID 33557709 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:163 |
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| Enthalten in: |
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 163(2020), 6 vom: 30. Dez., Seite 1144-1149 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Paderno, Alberto [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 14.12.2020 Date Revised 08.11.2021 published: Print-Electronic CommentIn: Otolaryngol Head Neck Surg. 2021 Nov;165(5):755. - PMID 33557709 Citation Status MEDLINE |
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| doi: |
10.1177/0194599820939538 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM311782477 |
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| 500 | |a CommentIn: Otolaryngol Head Neck Surg. 2021 Nov;165(5):755. - PMID 33557709 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To prospectively assess the rate and timing of recovery of olfactory (OD) and gustatory (GD) dysfunction in patients affected by COVID-19 | ||
| 520 | |a STUDY DESIGN: Cohort study | ||
| 520 | |a SETTING: Population-based evaluation in a COVID-19 high-prevalence region | ||
| 520 | |a SUBJECTS AND METHODS: We analyzed the clinical course of OD and GD in a cohort of home-quarantined SARS-CoV-2-positive patients from Northern Italy. Physicians administered a survey-based questionnaire at recruitment (T0). During follow-up, patients responded to online dedicated surveys modulated according to symptoms at T0 | ||
| 520 | |a RESULTS: A total of 151 patients completed the follow-up survey. OD and/or GD were observed in 83% and 89% of subjects, respectively. Resolution rates of OD and GD at 30 days from onset were 87% and 82%, respectively. Risk factors for late resolution were grade of dysfunction at onset (total vs partial), gender, and presence of nasal congestion. Three (2%) patients previously reporting complete resolution of symptoms complained of subsequent recurrence of OD and/or GD after a mean of 19 days from resolution of the previous episode | ||
| 520 | |a CONCLUSION: COVID-19-related OD and GD had high rate of resolution in the first month from onset of symptoms. However, in 10% to 15% of patients, these symptoms showed only partial improvement after this period | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a gustatory dysfunction | |
| 650 | 4 | |a olfactory dysfunction | |
| 650 | 4 | |a recovery | |
| 650 | 4 | |a smell | |
| 650 | 4 | |a taste | |
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| 700 | 1 | |a Grammatica, Alberto |e verfasserin |4 aut | |
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| 700 | 1 | |a Gualtieri, Tommaso |e verfasserin |4 aut | |
| 700 | 1 | |a Taboni, Stefano |e verfasserin |4 aut | |
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