Asymptomatic Strongyloidiasis among Latin American Migrants in Spain : A Community-Based Approach
Strongyloides stercoralis infection is frequently underdiagnosed since many infections remain asymptomatic.
AIM: To estimate the prevalence and characteristics of asymptomatic S. stercoralis infection in Latin American migrants attending a community-based screening program for Chagas disease in Spain.
METHODOLOGY: Three community-based Chagas disease screening campaigns were performed in Alicante (Spain) in 2016, 2017, and 2018. Serological testing for S. stercoralis infection was performed using a non-automatized IVD-ELISA detecting IgG (DRG Instruments GmbH, Marburg, Germany).
RESULTS: Of the 616 migrants from Central and South America who were screened, 601 were included in the study: 100 children and adolescents (<18 years of age) and 501 adults. Among the younger group, 6 participants tested positive (prevalence 6%, 95% confidence interval [CI] 2.5% to 13.1%), while 60 adults did so (prevalence 12%, 95% CI 9.3% to 15.3%). S. stercoralis infection was more common in men than in women (odds ratio adjusted [ORa] 2.28, 95% CI 1.289 to 4.03) and in those from Bolivia (ORa 2.03, 95% CI 1.15 to 3.59). Prevalence increased with age (ORa 1.02, 95% CI 0.99 to 1.05). In contrast, a university education had a protective effect (ORa 0.29, 95% CI 0.31 to 0.88). Forty-one (41/66; 62.1%) of the total cases of S. stercoralis infection were treated at the health care center. Positive stool samples were observed in 19.5% of the followed-up positive cases.
CONCLUSION: Incorporating serological screening for S. stercoralis into community-based screening for Chagas disease is a useful intervention to detect asymptomatic S. stercoralis infection in Central and South American migrants and an opportunity to tackle neglected tropical diseases in a transversal way. The remaining challenge is to achieve patients' adherence to the medical follow-up.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Pathogens (Basel, Switzerland) - 9(2020), 6 vom: 24. Juni |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ramos-Sesma, Violeta [VerfasserIn] |
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| Links: |
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| Themen: |
Central and South America |
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| Anmerkungen: |
Date Revised 28.09.2020 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/pathogens9060511 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM311779468 |
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| 245 | 1 | 0 | |a Asymptomatic Strongyloidiasis among Latin American Migrants in Spain |b A Community-Based Approach |
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| 500 | |a Date Revised 28.09.2020 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Strongyloides stercoralis infection is frequently underdiagnosed since many infections remain asymptomatic | ||
| 520 | |a AIM: To estimate the prevalence and characteristics of asymptomatic S. stercoralis infection in Latin American migrants attending a community-based screening program for Chagas disease in Spain | ||
| 520 | |a METHODOLOGY: Three community-based Chagas disease screening campaigns were performed in Alicante (Spain) in 2016, 2017, and 2018. Serological testing for S. stercoralis infection was performed using a non-automatized IVD-ELISA detecting IgG (DRG Instruments GmbH, Marburg, Germany) | ||
| 520 | |a RESULTS: Of the 616 migrants from Central and South America who were screened, 601 were included in the study: 100 children and adolescents (<18 years of age) and 501 adults. Among the younger group, 6 participants tested positive (prevalence 6%, 95% confidence interval [CI] 2.5% to 13.1%), while 60 adults did so (prevalence 12%, 95% CI 9.3% to 15.3%). S. stercoralis infection was more common in men than in women (odds ratio adjusted [ORa] 2.28, 95% CI 1.289 to 4.03) and in those from Bolivia (ORa 2.03, 95% CI 1.15 to 3.59). Prevalence increased with age (ORa 1.02, 95% CI 0.99 to 1.05). In contrast, a university education had a protective effect (ORa 0.29, 95% CI 0.31 to 0.88). Forty-one (41/66; 62.1%) of the total cases of S. stercoralis infection were treated at the health care center. Positive stool samples were observed in 19.5% of the followed-up positive cases | ||
| 520 | |a CONCLUSION: Incorporating serological screening for S. stercoralis into community-based screening for Chagas disease is a useful intervention to detect asymptomatic S. stercoralis infection in Central and South American migrants and an opportunity to tackle neglected tropical diseases in a transversal way. The remaining challenge is to achieve patients' adherence to the medical follow-up | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Central and South America | |
| 650 | 4 | |a Chagas disease | |
| 650 | 4 | |a Community-based intervention | |
| 650 | 4 | |a Strongyloides stercoralis | |
| 650 | 4 | |a Strongyloidiasis | |
| 650 | 4 | |a migrants | |
| 700 | 1 | |a Navarro, Miriam |e verfasserin |4 aut | |
| 700 | 1 | |a Llenas-García, Jara |e verfasserin |4 aut | |
| 700 | 1 | |a Gil-Anguita, Concepción |e verfasserin |4 aut | |
| 700 | 1 | |a Torrús-Tendero, Diego |e verfasserin |4 aut | |
| 700 | 1 | |a Wikman-Jorgensen, Philip |e verfasserin |4 aut | |
| 700 | 1 | |a Amador-Prous, Concepción |e verfasserin |4 aut | |
| 700 | 1 | |a Ventero-Martín, María-Paz |e verfasserin |4 aut | |
| 700 | 1 | |a Garijo-Sainz, Ana-María |e verfasserin |4 aut | |
| 700 | 1 | |a García-López, María |e verfasserin |4 aut | |
| 700 | 1 | |a Pujades-Tárraga, Ana-Isabel |e verfasserin |4 aut | |
| 700 | 1 | |a Bernal-Alcaraz, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Santonja, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Guevara-Hernández, Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a Flores-Chávez, María |e verfasserin |4 aut | |
| 700 | 1 | |a Saugar, José-María |e verfasserin |4 aut | |
| 700 | 1 | |a Ramos-Rincón, José-Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Corazones Sin Chagas Platform |e verfasserin |4 aut | |
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